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Disease-Modifying Therapy for Multiple Sclerosis
The therapeutic decision-making process in multiple sclerosis must now consider the availability of multiple medications, relative efficacy, potentially severe adverse events, tolerability, and patient preferences.
May 08, 2015
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New Trends in Spinal Cord Tissue Engineering
Neural tissue engineering treatments using a combination of scaffolds with stem cells, growth factors, and other bioactive agents have synergistic effects in the repair of spinal cord injury.
March 05, 2015
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Future of Epilepsy Treatment: Integration of Devices
Nearly one-third of patients with epilepsy remain refractory to medical therapy. The current review highlights how new and emerging devices and drug delivery systems can change how we treat epilepsy.
January 16, 2015
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Cognitive Dysfunction in Patients With Epilepsy: Focus on Clinical Variables
Cognitive dysfunction in epilepsy may result from the underlying brain disorder, potentially modifiable factors such as antiepileptic drug treatment, and epilepsy surgery.
January 14, 2015
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Use of Electroconvulsive Therapy in the Treatment of Catatonia
What role does modern electroconvulsive therapy play in the management of catatonia? The current review provides a practical and evidence-based guideline for physicians.
October 22, 2014
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Neuroimaging of Epilepsy: A Review of MRI Findings in Uncommon Etiologies and Atypical Presentations of Seizures
In patients with atypical or unusual epilepsy, appropriate, directed use of magnetic resonance imaging (MRI) and newer imaging methods enhances accurate diagnosis and detection of underlying epileptogenic foci that may respond to surgical resection.
September 17, 2014
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Monitoring Neurogenesis in the Cerebral Cortex — an Update
Determining the precise mechanisms controlling neurogenesis may offer a foundation for prospective future embryonic stem cell–based approaches to directed brain repair.
June 05, 2014
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Towards an Understanding of Neuropsychiatric Manifestations in Fragile X Premutation Carriers
Neuropsychiatric fragile X-associated disorders caused by "premutation" range expansions include neurodevelopmental, mood, and anxiety disorders and fragile X-associated tremor ataxia syndrome.
March 03, 2014
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Neurodegeneration in Spinal Muscular Atrophy: From Disease Phenotype and Animal Models to Therapeutic Strategies and Beyond
Spinal muscular atrophy is a relatively common neurodegenerative disease for which there has been recent progress in understanding the pathology, biology, and molecular genetics.
December 16, 2013
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Inflammation and Human Cerebral Aneurysms: Current and Future Treatment Prospects
Inflammation plays an important role in intracranial aneurysm formation and progression, suggesting potential noninvasive, molecularly targeted clinical therapeutic interventions.
October 28, 2013
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Beyond the Lesion: Neuroimaging Foundations for Poststroke Recovery
New neuroimaging techniques may elucidate and help manage poststroke recovery, based on task-related activation, functional connectivity, structural integrity, and cortical thickness.
August 28, 2013
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Advances in the Treatment of Visual Hallucinations in Neurodegenerative Diseases
Complex visual hallucinations are common, distressing, and disabling symptoms of neurodegenerative disorders, particularly the synucleinopathies, but treatment is not well advanced.
July 05, 2013
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The Genetics of Segawa Disease
Segawa disease, or hereditary progressive dystonia with marked diurnal fluctuation, is caused by abnormalities of the GTP-cyclohydrolase 1 gene and often responds to dopa.
May 03, 2013
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Diagnosis and Management of Pediatric Peripheral Neuropathies in Resource-Poor Settings
What is the current practice for diagnosing and treating pediatric peripheral neuropathies in resource-poor settings? The current review provides the answers.
February 28, 2013
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Pediatric Cerebral Malaria: A Scourge of Africa
Antimalarials and intense supportive care are required for optimal treatment of cerebral malaria, which affects up to 3 million people per year, mostly children in sub-Saharan Africa.
December 14, 2012
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Early Markers for Cerebral Palsy: Insights From the Assessment of General Movements
General movements have a high sensitivity and specificity for prediction of cerebral palsy, and evaluation of GMs is quick, noninvasive, and easy to learn.
November 07, 2012
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Advances in the Diagnosis of Leukodystrophies
Leukodystrophies are inherited disorders of the central nervous system white matter and are classified based on MRI as demyelinating (classic) or hypomyelinating.
September 10, 2012
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Management of African Trypanosomiasis of the CNS: Polysomnography as a Noninvasive Staging Tool
Noninvasive polysomnography may be an alternative to lumbar puncture for staging of, human African trypanosomiasis (sleeping sickness), especially during follow-up examinations.
July 10, 2012
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Indications and Limitations of Endoscopic Skull Base Surgery
Knowing the indications for and limitations of endoscopic endonasal approaches should improve patient selection, potentially resulting in superior surgical outcomes and less morbidity.
May 10, 2012
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Facing the Unique Challenges of Dyskinesias in Parkinson’s Disease
Dyskinesia resulting from levodopa and dopaminergic drug therapy in advanced Parkinson disease has a negative impact on quality of life and is difficult to manage.
March 08, 2012
