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Diagnosis and Management of Atherosclerotic Renal Artery Stenosis: Improving Patient Selection and Outcomes
Atherosclerotic renal artery stenosis is associated with a high rate of mortality by the time that it leads to end-stage renal disease. The current review highlights how to diagnose and treat renal artery stenosis before it is too late.
February 23, 2009
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Fixed-Dose Combination Therapy and Secondary Cardiovascular Prevention: Rationale, Selection of Drugs and Target Population
This review discusses the problems faced by prevention of adverse cardiovascular events, and provides evidence for the need for fixed-dose combination drugs or "polypills" in this setting.
December 23, 2008
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Platelet ADP-receptor Antagonists for Cardiovascular Disease: Past, Present and Future
The routine use of clopidogrel has advanced secondary treatment of cardiovascular disease, and new agents may promote even better outcomes. The current review examines best practices in the use of antiplatelet medications.
December 01, 2008
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Adverse Cardiovascular Effects of Air Pollution
Air pollution can increase the overall risk for mortality, and it can promote cardiovascular disease in particular. The current review examines the pathophysiology and evidence for the link between air pollution and cardiovascular disease.
November 25, 2008
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Fulminant Myocarditis
September 18, 2008
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Mechanisms of Disease: The Evolving Role of Regulatory T Cells in Atherosclerosis
Regulatory T cells may help reduce the burden of atherosclerosis. The current review summarizes emerging research on these cells.
September 01, 2008
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Evaluation and Management of the Adult Patient With Transposition of the Great Arteries Following Atrial-level (Senning or Mustard) Repair
Atrial-level repair of transposition of the great arteries was a significant advance in medicine that offered hope to patients and families when there was none before. However, many patients who received these procedures now have complications, and the current article describes these conditions and their management.
August 01, 2008
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Molecular MRI of Hematopoietic Stem-progenitor Cells: In Vivo Monitoring of Gene Therapy and Atherosclerosis
Molecular MRI allows use of labeled hematopoietic stem-progenitor cells to identify diffuse atherosclerosis. New techniques in molecular MRI of atherosclerosis and their potential applications in clinical practice are reviewed.
July 01, 2008
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Spotlight on HDL-raising Therapies: Insights From the Torcetrapib Trials
A large trial of a medication designed to raise HDL was stopped early because of a higher risk for death among subjects receiving active treatment. However, HDL-raising therapy may still have an important role in the prevention or management of cardiovascular disease. The current article reviews these treatments.
June 01, 2008
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Mechanisms of Disease: Molecular Genetics of Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
The etiology of arrhythmogenic right ventricular dysplasia/cardiomyopathy involves environmental factors and genetic modifiers. Recent genetic advances, hypothetical disease mechanisms, and the role of clinical genetic testing in diagnosis and prognosis are reviewed.
March 27, 2008
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Technology Insight: Magnetic Navigation in Coronary Interventions
Magnetic navigation offers a novel approach for percutaneous coronary intervention. Technological advancements in interventional cardiology and the potential applications of magnetic navigation in the field are reviewed.
March 01, 2008
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Technology Insight: In Vivo Coronary Plaque Classification by Intravascular Ultrasonography Radiofrequency Analysis
Intravascular ultrasonography (IVUS) assesses plaque area and IVUS-derived virtual histology provides detailed plaque morphology. The uses of these tools in coronary artery assessment in patients at risk for acute coronary syndromes are reviewed.
February 26, 2008
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Rapid Regression of Atherosclerosis: Insights From the Clinical and Experimental Literature
Whether human atheromata can regress is controversial. Animal model studies showing atheroma plaque shrinkage or reversal of atherosclerosis, and examples of plaque regression in humans are presented.
February 01, 2008
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Stress (Takotsubo) Cardiomyopathy -- A Novel Pathophysiological Hypothesis to Explain Catecholamine-induced Acute Myocardial Stunning
January 01, 2008
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Surgery Insight: Carotid Endarterectomy -- Which Patients to Treat and When?
November 01, 2007
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Mechanisms of Disease: The Genetic Basis of Coronary Heart Disease
October 01, 2007
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Surgery Insight: Septal Myectomy for Obstructive Hypertrophic Cardiomyopathy -- The Mayo Clinic Experience
September 01, 2007
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Mechanisms of Disease: Toll-like Receptors in Cardiovascular Disease
Inhibition of toll-like receptors is an intriguing concept in the prevention and treatment of cardiovascular disease. The current review highlights what is known in regard to these innate immune receptors.
August 01, 2007
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Drug Insight: Aldosterone-Receptor Antagonists in Heart Failure -- The Journey Continues
Aldosterone receptor antagonists offer tremendous potential to help patients with heart failure. The current review examines the best practices of using these medications.
July 01, 2007
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Pulmonary Arterial Hypertension: Current Therapeutic Strategies
Emerging treatments for pulmonary arterial hypertension promise to change the way that physicians care for this important disease. This review addresses existing therapies for pulmonary arterial hypertension as well as treatments on the horizon.
June 01, 2007
