As the most common progressive joint disorder in the United States, osteoarthritis affects 13.9% of adults aged 25 years and older and 33.6% of those older than 65 years, with an increasing prevalence because of an aging population. In addition, acute and chronic pain remains poorly managed, with many patients receiving ineffective or inappropriate analgesia, along with well-publicized findings showing that opioid analgesics are often overprescribed. This page provides education on the safety and efficacy of OTC pharmacotherapies for pain and practical considerations for their effective use in osteoarthritis and other inflammatory conditions.