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Pathways in Pediatric NF1-Associated Tumors: Insights on What Clinicians Know, Want, and Need

  • Authors: Matthias A. Karajannis, MD, MS; Amy Armstrong, MD
  • CME / ABIM MOC Released: 11/13/2023
  • Valid for credit through: 11/13/2024, 11:59 PM EST
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  • Credits Available

    Physicians - maximum of 1.25 AMA PRA Category 1 Credit(s)™

    ABIM Diplomates - maximum of 1.25 ABIM MOC points

    You Are Eligible For

    • Letter of Completion
    • ABIM MOC points

Target Audience and Goal Statement

This activity is intended for pediatricians, oncologists, neurologists, surgeons, and other clinicians who treat patients with neurofibromatosis type 1 (NF1)-associated tumors.

The goal of this activity is for learners to be better able to recognize the nuances of pediatric NF1-associated tumors and how best to care for affected patients as part of the multidisciplinary team.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Latest clinical evidence evaluating pharmacologic therapies for the management of pediatric NF1-associated tumors
  • Have greater competence related to
    • Identifying clinical hallmarks of NF1-associated tumors in the pediatric patient population
    • Designing individualized care plans for pediatric patients with NF1-associated tumors
  • Demonstrate greater confidence in their ability to
    • Collaboratively address unmet needs in the comprehensive care of pediatric patients with NF1-associated tumors


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All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated according to Medscape policies. Others involved in the planning of this activity have no relevant financial relationships.


  • Matthias A. Karajannis, MD, MS

    Chief, Pediatric Neuro-Oncology Service
    Department of Pediatrics
    Memorial Sloan Kettering Cancer Center
    Professor of Pediatrics
    Weill Cornell Medical College
    New York, New York


    Matthias A. Karajannis, MD, MS, has the following relevant financial relationships:
    Consultant or advisor for: Cardinal Health; CereXis; QED Therapeutics; Recursion
    Research funding from: Y-mAbs
    Owns stock (publicly traded) in: 3M; Doximity

  • Amy Armstrong, MD

    Assistant Professor of Pediatrics
    Washington University School of Medicine
    St. Louis Children's Hospital
    Division of Pediatric Hematology/Oncology
    St. Louis, Missouri


    Amy Armstrong, MD, has the following relevant financial relationships:
    Consultant or advisor for: Alexion Pharmaceuticals
    Speaker or member of speakers bureau for: Alexion Pharmaceuticals


  • John Churchwell, PhD

    Medical Education Director, Medscape, LLC


    John Churchwell, PhD, has the following relevant financial relationships:
    Formerly employed by an ineligible company: Medtronic, Inc.

Compliance Reviewer

  • Stephanie Corder, ND, RN, CHCP

    Associate Director, Accreditation and Compliance, Medscape, LLC


    Stephanie Corder, ND, RN, CHCP, has no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has no relevant financial relationships.

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Interprofessional Continuing Education

In support of improving patient care, Medscape, LLC is jointly accredited with commendation by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 1.25 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.25 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

    College of Family Physicians of Canada Mainpro+® participants may claim certified credits for any AMA PRA Category 1 credit(s)™, up to a maximum of 50 credits per five-year cycle. Any additional credits are eligible as non-certified credits. College of Family Physicians of Canada (CFPC) members must log into Mainpro+® to claim this activity.

    Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

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For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]

Instructions for Participation and Credit

There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 70% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read about the target audience, learning objectives, and author disclosures.
  2. Study the educational content online or print it out.
  3. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate, but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period, you can print out the tally as well as the certificates from the CME/CE Tracker.

*The credit that you receive is based on your user profile.


Pathways in Pediatric NF1-Associated Tumors: Insights on What Clinicians Know, Want, and Need

Authors: Matthias A. Karajannis, MD, MS; Amy Armstrong, MDFaculty and Disclosures

CME / ABIM MOC Released: 11/13/2023

Valid for credit through: 11/13/2024, 11:59 PM EST


Educational Impact Challenge

Please answer the questions below to self-assess your knowledge. Answering these questions again after the activity will allow you to see what you learned.

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