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Table 1.  

Behavior/Substance Prevalence  
2009% 2011% 2013% 2015% 2017% 2019% 2021% Linear change Quadratic change Change during2019–2021§
Current use
Alcohol 41.8 38.7 34.9 32.8 29.8 29.2 22.7 Decreased 2009–2021 No change Decreased
Marijuana 20.8 23.1 23.4 21.7 19.8 21.7 15.8 Decreased 2009–2021 Increased 2009–2013Decreased 2013–2021 Decreased
Binge drinking NA NA NA NA 13.5 13.7 10.5 Decreased 2017–2021 —** Decreased
Prescription opioid misuse NA NA NA NA NA 7.2 6.0 No change
Lifetime use
Alcohol 68.4 66.7 63.4 60.9 56.5 56.5 47.4 Decreased 2009–2021 Decreased 2009–2017Decreased 2017–2021 Decreased
Marijuana 36.8 39.9 40.7 38.6 35.6 36.8 27.8 Decreased 2009–2021 Increased 2009–2013Decreased 2013–2021 Decreased
Inhalants 11.7 11.4 8.9 7.0 6.2 6.4 8.1 Decreased 2009–2021 Decreased 2009–2017Increased 2017–2021 Increased
Ecstasy 6.7 8.2 6.6 5.0 4.0 3.6 2.9 Decreased 2009–2021 No change 2009–2013Decreased 2013–2021 No change
Cocaine 6.4 6.8 5.5 5.2 4.8 3.9 2.5 Decreased 2009–2021 No change 2009–2017Decreased 2017–2021 Decreased
Methamphetamine 4.1 3.8 3.2 3.0 2.5 2.1 1.8 Decreased 2009–2021 No change No change
Heroin 2.5 2.9 2.2 2.1 1.7 1.8 1.3 Decreased 2009–2021 No change No change
Injection drug use 2.1 2.3 1.7 1.8 1.5 1.6 1.4 Decreased 2009–2021 No change No change
Synthetic marijuana NA NA NA 9.2 6.9 7.3 6.5 Decreased 2015–2021 No change
Prescription opioid misuse NA NA NA NA 14.0 14.3 12.2 Decreased 2017–2021 Decreased

Table 1. Trends in prevalence of current and lifetime use of specific substances among high school students — Youth Risk Behavior Survey, United States, 2009–2021*

Abbreviation: NA = not available.
*2009: N = 16,410 respondents; 2011: N = 15,425 respondents; 2013: N = 13,583 respondents; 2015: N = 15,624 respondents; 2019: N = 13,677 respondents; 2021: N = 17,232 respondents. Because the state and local questionnaires differ by jurisdiction, students in these schools were not asked all national YRBS questions. Therefore, the total number (N) of students answering each question varied. Percentages in each category are calculated on the known data.
On the basis of trend analyses from a logistic regression model controlling for sex, race and ethnicity, and grade (p<0.05).
§On the basis of t-test analysis with Taylor series linearization (p<0.05).
Previous 30 days before the survey.
**Dashes indicate insufficient years of data to assess trends.

Table 2.  

Behavior/Substance Sex
Male Female
2019% 2021% PD (95% CI) PR (95% CI) 2019% 2021 % PD (95% CI) PR (95% CI)
Current use
Alcohol 26.4 18.8 −7.7 (−0.3 to −5.1)§ 0.7 (0.6 to 0.8)§ 31.9 26.8 −5.1 (−8.3 to −1.9)§ 0.8 (0.8 to 0.9)§
Marijuana 22.5 13.6 −8.9 (−1.3 to −6.4)§ 0.6 (0.5 to 0.7)§ 20.8 17.8 −3.0 (−6.0 to 0.0) 0.9 (0.7 to 1.0)
Binge drinking 12.7 9.0 −3.7 (−5.6 to −1.7)§ 0.7 (0.6 to 0.8)§ 14.6 12.2 −2.5 (−5.2 to 0.2) 0.8 (0.7 to 1.0)
Prescription opioid misuse 6.1 4.0 −2.1 (−3.5 to −0.8)§ 0.7 (0.5 to 0.9)§ 8.3 8.0 −0.3 (−2.2 to 1.6) 1.0 (0.8 to 1.2)
Lifetime use
Alcohol 53.1 42.0 −11.1 (−14.2 to −8.0)§ 0.8 (0.7 to 0.8)§ 60.0 53.2 −6.9 (−10.2 to −3.5)§ 0.9 (0.8 to 0.9)§
Marijuana 37.0 24.8 −12.3 (−15.9 to −8.7)§ 0.7 (0.6 to 0.8)§ 36.5 30.9 −5.6 (−9.3 to −1.9)§ 0.9 (0.8 to 1.0)§
Inhalants 5.7 6.8 1.1 (−0.1 to 2.3) 1.2 (1.0 to 1.5) 6.9 9.4 2.5 (1.1 to 3.9)§ 1.4 (1.1 to 1.6)§
Ecstasy 4.6 2.9 −1.7 (−2.8 to −0.7)§ 0.6 (0.5 to 0.8)§ 2.4 2.7 0.4 (−0.5 to 1.3) 1.2 (0.8 to 1.7)
Cocaine 4.9 2.6 −2.3 (−3.3 to −1.4)§ 0.5 (0.4 to 0.7)§ 2.7 2.2 −0.5 (−1.6 to 0.5) 0.8 (0.5 to 1.2)
Methamphetamine 2.7 1.9 −0.8 (−1.6 to 0.0) 0.7 (0.5 to 1.0) 1.5 1.4 −0.1 (−0.8 to 0.6) 1.0 (0.6 to 1.5)
Heroin 2.3 1.6 −0.7 (−1.5 to 0.1) 0.7 (0.5 to 1.0) 1.0 0.8 −0.3 (−0.9 to 0.4) 0.8 (0.4 to 1.5)
Injection drug use 2.1 1.7 −0.4 (−1.2 to 0.4) 0.8 (0.5 to 1.2) 1.1 0.9 −0.2 (−0.9 to 0.6) 0.9 (0.4 to 1.8)
Synthetic marijuana 7.2 5.8 −1.4 (−2.9 to 0.1) 0.8 (0.6 to 1.0) 7.4 7.1 −0.3 (−1.9 to 1.3) 1.0 (0.8 to 1.2)
Prescription opioid misuse 12.4 9.5 −2.9 (−4.7 to −1.2)§ 0.8 (0.7 to 0.9)§ 16.1 14.8 −1.4 (−3.9 to 1.1) 0.9 (0.8 to 1.1)

Table 2. Prevalence of and changes in prevalence of current and lifetime use of specific substances among high school students, by sex — Youth Risk Behavior Survey, United States, 2019 and 2021*

Abbreviations: PD = prevalence difference; PR = prevalence ratio.
*2019: N = 13,677 respondents; 2021: N = 17,232 respondents. Because the state and local questionnaires differ by jurisdiction, students in these schools were not asked all national YRBS questions. Therefore, the total number (N) of students answering each question varied. Percentages in each category are calculated on the known data.
Previous 30 days before the survey.
§Statistically significant results (p<0.05).
Significantly different from male students in 2021, on the basis of t-test analysis with Taylor series linearization (p<0.05).

Table 3.  

Behavior/Substance Race and ethnicity
Black or African American White Hispanic or Latino
2019% 2021 % PD (95% CI) PR (95% CI) 2019% 2021% PD (95% CI) PR (95% CI) 2019% 2021 % PD (95% CI) PR (95% CI)
Current use§
Alcohol 16.8 13.2 −3.6 (−7.7 to 0.5) 0.8 (0.6 to 1.0) 34.2 25.9 −8.3 (−11.4 to −5.3)** 0.8 (0.7 to 0.8)** 28.4 22.9¶,†† −5.5 (−9.5 to −1.6)** 0.8 (0.7 to 1.0)**
Marijuana 21.7 20.5 −1.2 (−5.4 to 2.9) 0.9 (0.8 to 1.2) 22.1 14.8 −7.3 (−10.2 to −4.5)** 0.7 (0.6 to 0.8)** 22.4 16.7†† -5.7 (−9.2 to −2.2)** 0.7 (0.6 to 0.9)**
Binge drinking 6.2 4.1 −2.2 (−4.8 to 0.5) 0.7 (0.4 to 1.0) 17.3 13.3 −4.0 (−6.6 to −1.4)** 0.8 (0.7 to 0.9)** 12.4 10.1¶,†† −2.3 (−4.8 to 0.1) 0.8 (0.7 to 1.0)
Prescription opioid misuse 8.7 8.6 −0.1 (−4.2 to 3.9) 1.0 (0.6 to 1.6) 5.5 4.6 −1.0 (−2.5 to 0.5) 0.8 (0.6 to 1.1) 9.8 8.3 −1.5 (−4.0 to 1.1) 0.9 (0.6 to 1.1)
Lifetime use
Alcohol 47.2 39.4 −7.8 (−13.5 to −2.0)** 0.8 (0.7 to 1.0)** 58.8 50.0 −8.8 (−12.0 to −5.6)** 0.9 (0.8 to 0.9)** 60.4 50.4†† −10.0 (−14.5 to −5.5)** 0.8 (0.8 to 0.9)**
Marijuana 37.5 33.3 −4.2 (−10.5 to 2.2) 0.9 (0.7 to 1.1) 36.8 26.2 −10.7 (−14.1 to −7.2)** 0.7 (0.6 to 0.8)** 39.2 31.2 −7.9 (−12.5 to −3.4)** 0.8 (0.7 to 0.9)**
Inhalants 7.2 7.0 −0.2 (−2.5 to 2.1) 1.0 (0.7 to 1.3) 6.3 8.3 1.9 (0.3 to 3.6)** 1.3 (1.1 to 1.6)** 6.6 8.2 1.6 (−0.1 to 3.3) 1.2 (1.0 to 1.6)
Ecstasy 3.8 2.7 −1.1 (−2.9 to 0.7) 0.7 (0.4 to 1.2) 2.7 2.9 0.1 (−0.9 to 1.2) 1.1 (0.7 to 1.5) 4.4 2.7 -1.7 (−2.7 to −0.7)** 0.6 (0.5 to 0.8)**
Cocaine 4.0 1.9 −2.1 (−3.8 to −0.4)** 0.5 (0.3 to 0.8)** 2.9 2.4 −0.5 (−1.4 to 0.4) 0.8 (0.6 to 1.1) 5.6 2.9 −2.7 (−4.4 to −1.0)** 0.5 (0.3 to 0.8)**
Methamphetamine 3.8 2.0 −1.9 (−3.7 to 0.0) 0.5 (0.3 to 0.9)** 1.2 1.4 0.2 (−0.3 to 0.7) 1.2 (0.8 to 1.7) 2.7 2.3 −0.4 (−1.6 to 0.8) 0.9 (0.5 to 1.3)
Heroin 3.4 1.7 −1.7 (−3.4 to −0.1)** 0.5 (0.3 to 0.9)** 0.9 1.0 0.1 (−0.3 to 0.5) 1.2 (0.8 to 1.8) 2.4 1.6 −0.9 (−2.1 to 0.4) 0.7 (0.4 to 1.1)
Injection drug use 2.9 1.9 −0.9 (−3.0 to 1.1) 0.7 (0.3 to 1.5) 0.8 1.1 0.3 (−0.3 to 0.8) 1.4 (0.8 to 2.4) 2.5 1.8 −0.7 (−1.8 to 0.3) 0.7 (0.4 to 1.2)
Synthetic marijuana 5.7 6.8 1.1 (−1.2 to 3.3) 1.2 (0.8 to 1.7) 6.7 6.5 −0.2 (−1.6 to 1.3) 1.0 (0.8 to 1.2) 9.8 6.8 −3.1 (−4.9 to −1.3)** 0.7 (0.6 to 0.9)**
Prescription opioid misuse 15.3 13.6 −1.7 (−5.4 to 1.9) 0.9 (0.7 to 1.1) 12.7 11.2 −1.4 (−3.7 to 0.8) 0.9 (0.7 to 1.1) 16.0 13.8 −2.2 (−5.5 to 1.2) 0.9 (0.7 to 1.1)

Table 3. Prevalence of and changes in prevalence of current and lifetime use of specific substances among high school students, by race and ethnicity — Youth Risk Behavior Survey, United States, 2019 and 2021*

Abbreviations: PD = prevalence difference; PR = prevalence ratio.
*2019: N = 13,677 respondents; 2021: N = 17,232 respondents. Because the state and local questionnaires differ by jurisdiction, students in these schools were not asked all national YRBS questions. Therefore, the total number (N) of students answering each question varied. Percentages in each category are calculated on the known data.
Persons of Hispanic or Latino (Hispanic) origin might be of any race but are categorized as Hispanic; all racial groups are non-Hispanic.
§Previous 30 days before the survey.
Significantly different from White students in 2021, on the basis of t-test analysis with Taylor series linearization (p<0.05).
**Statistically significant results (p<0.05).
††Significantly different from Black or African American students in 2021, on the basis of t-test analysis with Taylor series linearization (p<0.05).

Table 4.  

Behavior/Substance Heterosexual % Lesbian, gay, or bisexual % Questioning or other %
Current use
Alcohol 21.6 29.3§ 20.9
Marijuana 14.0 25.6§ 16.5§,¶
Binge drinking 10.3 13.6§ 7.6§,¶
Prescription opioid misuse 4.3 11.7§ 10.3§
Lifetime use
Alcohol 45.8 58.0§ 46.2
Marijuana 25.8 41.2§ 27.5
Inhalants 6.0 15.1§ 13.4§
Ecstasy 2.1 6.0§ 3.9§,¶
Cocaine 1.8 4.4§ 3.1§
Methamphetamine 1.1 3.4§ 3.0§
Heroin 0.8 1.9§ 2.4§
Injection drug use 1.0 1.9§ 2.7§
Synthetic marijuana 5.9 9.7§ 6.1
Prescription opioid misuse 9.4 21.5§ 18.6§

Table 4. Prevalence of current and lifetime use of specific substances among high school students, by sexual identity — Youth Risk Behavior Survey, United States, 2021*

*N = 17,232 respondents. Because the state and local questionnaires differ by jurisdiction, students in these schools were not asked all national YRBS questions. Therefore, the total number (N) of students answering each question varied. Percentages in each category are calculated on the known data.
Previous 30 days before the survey.
§Significantly different from heterosexual students, based on t-test analysis with Taylor series linearization (p<0.05).
Significantly different from lesbian, gay, or bisexual students, based on t-test analysis with Taylor series linearization (p<0.05).

CME / ABIM MOC / CE

Alcohol and Other Substance Use Before and During the COVID-19 Pandemic Among High School Students — Youth Risk Behavior Survey, United States, 2021

  • Authors: Brooke E. Hoots, PhD; Jingjing Li, PhD, MD; Marci Feldman Hertz, MS; Marissa B. Esser, PhD; Adriana Rico, MPH; Evelyn Y. Zavala, MPH; Christopher M. Jones, PharmD, DrPH
  • CME / ABIM MOC / CE Released: 10/3/2023
  • Valid for credit through: 10/3/2024, 11:59 PM EST
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Target Audience and Goal Statement

This activity is intended for primary care clinicians, pediatricians, addiction medicine specialists, and other healthcare professionals who treat and manage adolescents.

The goal of this activity is for members of the healthcare team to be better able to assess trends in the epidemiology of substance use among US high school students.

Upon completion of this activity, participants will:

  • Distinguish rates of substance use among US high school students in 2021
  • Assess trends in substance use among US high school students from 2019 to 2021
  • Evaluate substance use patterns among female and male high school students in 2021
  • Analyze substance use among different demographic groups of high school students in 2021


Faculty

  • Brooke E. Hoots, PhD

    Division of Overdose Prevention
    National Center for Injury Prevention and Control
    Centers for Disease Control and Prevention
    Atlanta, Georgia

    Disclosures

    Brooke E. Hoots, PhD, has no relevant financial relationships.

  • Jingjing Li, PhD, MD

    Division of Adolescent and School Health
    National Center for HIV, Viral Hepatitis, STD, and TB Prevention
    Centers for Disease Control and Prevention
    Atlanta, Georgia

    Disclosures

    Jingjing Li, PhD, MD, has no relevant financial relationships.

  • Marci Feldman Hertz, MS

    Division of Adolescent and School Health
    National Center for HIV, Viral Hepatitis, STD, and TB Prevention
    Centers for Disease Control and Prevention
    Atlanta, Georgia

    Disclosures

    Marci Feldman Hertz, MS, has no relevant financial relationships.

  • Marissa B. Esser, PhD

    Division of Population Health
    National Center for Chronic Disease Prevention and Health Promotion
    Centers for Disease Control and Prevention
    Atlanta, Georgia

    Disclosures

    Marissa B. Esser, PhD, has no relevant financial relationships.

  • Adriana Rico, MPH

    Division of Adolescent and School Health
    National Center for HIV, Viral Hepatitis, STD, and TB Prevention
    Centers for Disease Control and Prevention
    Atlanta, Georgia

    Disclosures

    Adriana Rico, MPH, has no relevant financial relationships.

  • Evelyn Y. Zavala, MPH

    Division of Adolescent and School Health
    National Center for HIV, Viral Hepatitis, STD, and TB Prevention
    Centers for Disease Control and Prevention
    Atlanta, Georgia

    Disclosures

    Evelyn Y. Zavala, MPH, has no relevant financial relationships.

  • Christopher M. Jones, PharmD, DrPH

    Office of the Director
    National Center for Injury Prevention and Control
    Centers for Disease Control and Prevention
    Atlanta, Georgia

    Disclosures

    Christopher M. Jones, PharmD, DrPH, has no relevant financial relationships.

CME Author

  • Charles P. Vega, MD

    Health Sciences Clinical Professor of Family Medicine
    University of California, Irvine School of Medicine

    Disclosures

    Charles P. Vega, MD, has the following relevant financial relationships:
    Consultant or advisor for: Boehringer Ingelheim; GlaxoSmithKline; Johnson & Johnson

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  • Stephanie Corder, ND, RN, CHCP

    Associate Director, Accreditation and Compliance, Medscape, LLC

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CME / ABIM MOC / CE

Alcohol and Other Substance Use Before and During the COVID-19 Pandemic Among High School Students — Youth Risk Behavior Survey, United States, 2021

Authors: Brooke E. Hoots, PhD; Jingjing Li, PhD, MD; Marci Feldman Hertz, MS; Marissa B. Esser, PhD; Adriana Rico, MPH; Evelyn Y. Zavala, MPH; Christopher M. Jones, PharmD, DrPHFaculty and Disclosures

CME / ABIM MOC / CE Released: 10/3/2023

Valid for credit through: 10/3/2024, 11:59 PM EST

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Abstract and Introduction

Abstract

Adolescence is a critical phase of development and is frequently a period of initiating and engaging in risky behaviors, including alcohol and other substance use. The COVID-19 pandemic and associated stressors might have affected adolescent involvement in these behaviors. To examine substance use patterns and understand how substance use among high school students changed before and during the COVID-19 pandemic, CDC analyzed data from the nationally representative Youth Risk Behavior Survey. This report presents estimated prevalences among high school students of current (i.e., previous 30 days) alcohol use, marijuana use, binge drinking, and prescription opioid misuse and lifetime alcohol, marijuana, synthetic marijuana, inhalants, ecstasy, cocaine, methamphetamine, heroin, and injection drug use and prescription opioid misuse. Trends during 2009–2021 were assessed using logistic regression and joinpoint regression analyses. Changes in substance use from 2019 to 2021 were assessed using prevalence differences and prevalence ratios, stratified by demographic characteristics. Prevalence of substance use measures by sexual identity and current co-occurring substance use were estimated using 2021 data. Substance use prevalence declined during 2009–2021. From 2019 to 2021, the prevalence of current alcohol use, marijuana use, and binge drinking and lifetime use of alcohol, marijuana, and cocaine and prescription opioid misuse decreased; lifetime inhalant use increased. In 2021, substance use varied by sex, race and ethnicity, and sexual identity. Approximately one third of students (29%) reported current use of alcohol or marijuana or prescription opioid misuse; among those reporting current substance use, approximately 34% used two or more substances. Widespread implementation of tailored evidence-based policies, programs, and practices likely to reduce risk factors for adolescent substance use and promote protective factors might further decrease substance use among U.S. high school students and is urgently needed in the context of the changing marketplaces for alcohol beverage products and other drugs (e.g., release of high-alcohol beverage products and increased availability of counterfeit pills containing fentanyl).

Introduction

Adolescence is a critical phase of physical, cognitive, social, and emotional development and is frequently a period of initiating and engaging in risky behaviors, including alcohol and other substance use. The majority of adolescents engage in some form of substance use before finishing high school.[1,2] Substance use during adolescence is associated with adverse health outcomes, such as mental health problems, teen pregnancy, and sexually transmitted diseases as well as consequences, such as delinquency, violence, and academic underachievement.[2,3] Substance use initiation during adolescence can increase the risk for substance use later in adulthood and increase the risk for substance use disorders (https://addiction.surgeongeneral.gov/sites/default/files/surgeon-generals-report.pdf). Adolescent substance use is of particular concern as overdose deaths among adolescents have increased dramatically.[4] The Drug Enforcement Administration has warned of readily available counterfeit pills containing highly lethal substances (e.g., illicit fentanyl) and other synthetic opioids that are designed to look like commonly misused prescription medications that might be contributing to these increases (https://www.dea.gov/press-releases/2021/05/21/dea-issues-warning-over-counterfeit-pills; https://www.dea.gov/sites/default/files/2021-05/Counterfeit%20Pills%20fact%20SHEET-5-13-21-FINAL.pdf). The alcohol industry and regulatory environment is also changing, including the release of high-alcohol content products (https://www.samhsa.gov/resource/ebp/implementing-community-level-policies-prevent-alcohol-misuse). In addition, alcohol-related deaths, including those involving other substances, have increased among adolescents.[5]

In 2021, CDC's Adolescent Behaviors and Experiences Survey (ABES) found that students experienced adversities and challenges during the COVID-19 pandemic, such as poor mental health, persistent feelings of sadness or hopelessness, suicidal ideation, and physical and emotional abuse, all of which are risk factors for substance use (https://www.cdc.gov/healthyyouth/data/abes/reports.htm). In addition, measures to protect adolescents from COVID-19 infection, such as remote schooling, social isolation, and event cancelation, might have contributed additional risk for adolescent substance use. One third of students participating in ABES who had ever drunk alcohol or used drugs used those substances more during the pandemic.[6]

Other studies examining adolescent substance use during the pandemic have had varying findings. For example, the Monitoring the Future survey indicated declines in current marijuana use, alcohol use, and binge drinking when comparing 2020 and 2021 prevalence estimates.[1] However, another study comparing prevalence estimates from the early stages of the pandemic to prepandemic estimates found increases in the frequency of both marijuana and alcohol use,[3] and another demonstrated no change in the use of either substance.[7]

The variability in the previous studies highlighted the need for additional studies of nationally representative data to assess changes in alcohol and other substance use before and during the pandemic. This report used Youth Risk Behavior Survey (YRBS) data to improve understanding of how substance use changed before and during the COVID-19 pandemic. Specifically, this report examined overall trends in alcohol and other substance use, characterized changes in alcohol and other substance use by demographic groups, and examined co-occurring substance use among U.S. high school students. Public health practitioners, clinicians, school officials, and policymakers can use these findings to expand evidence-based prevention programs, practices, and policies that reduce adolescent substance use risk factors and promote protective factors.