You are leaving Medscape Education
Cancel Continue
Log in to save activities Your saved activities will show here so that you can easily access them whenever you're ready. Log in here CME & Education Log in to keep track of your credits.
 

CME

Targeting Pathways of Disease Progression in Early Multiple Sclerosis

  • Authors: Amit Bar-Or, MD, FRCPC, Chair; Wallace J. Brownlee, MBChB, PhD, FRACP; Anne H. Cross, MD; Jiwon Oh, MD, PhD, FRPC
  • CME Released: 6/30/2023
  • Valid for credit through: 6/30/2024, 11:59 PM EST
Start Activity

  • Credits Available

    Physicians - maximum of 1.50 AMA PRA Category 1 Credit(s)™

    You Are Eligible For

    • Letter of Completion

Target Audience and Goal Statement

Neurologists, neuroscientists, nurse practitioners, neuroscience nurses and other healthcare professionals involved in the clinical study, management, and care of patients with multiple sclerosis.

This CME activity will highlight the importance of targeting pathways of disease progression in early multiple sclerosis (MS), including the developing role of Bruton’s tyrosine kinase (BTK) inhibitors. This class of agents disarms both the peripheral (i.e., lymphocyte) and central, chronically activated (i.e., microglia/macrophage) cells that are dysregulated in MS. By targeting multiple biological processes that include B-cell and macrophage activation, the BTK pathway is under clinical investigation to determine its potential role in mitigating disease activity across the spectrum of MS.

The educational goals of this activity are to equip neurologists with the knowledge and strategies to evaluate the potential role of this class of emerging agents in MS, as well as to assess imminent topline results from Phase III clinical trials, and to better predict the role of BTK inhibition within the current armamentarium of disease modifying therapies. To do so, clinicians will need to better understand the potential targets for BTK inhibition, as well as to analyze the current preclinical and clinical trial data, and to anticipate how these potential agents may change the current treatment paradigm.

Upon completion of this activity, participants will be able to:

  1. Explain potential targets for intervention that impact disease progression in MS
  2. Examine BTK effects on neuroinflammation and neurodegeneration in MS and how inhibition potentially provides dual approaches to disarming both the peripheral and central pathways that are dysregulated in MS
  3. Analyze ongoing clinical trials designed to determine the efficacy and safety of emerging BTK inhibitors
  4. Propose comprehensive treatment strategies with emerging therapies early in the disease course that may reduce disability and disease progression
  5. Identify future clinical and research questions to elucidate potential role and use of emerging therapies


Disclosures

Letters & Sciences and PACE require planners, faculty, and others who are in positions to control the content of this activity to disclose all financial relationships they may have with ineligible companies. All relevant financial relationships are thoroughly vetted and mitigated according to the providers' policies. Letters & Sciences and PACE are committed to providing learners with high-quality accredited CME activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

Faculty

All identified real or perceived COI have been thoroughly vetted and resolved according to the providers’ policies. Letters & Sciences and PACE are committed to providing learners with high quality accredited activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.


Chair

  • Amit Bar-Or, MD, FRCPC, Chair

    Professor, Melissa and Paul Anderson Chair
    Director, Center for Neuroinflammation and Neurotherapeutics
    Chief, Division of MS and Related Disorders
    Hospital of the University of Pennsylvania
    Philadelphia, Pennsylvania, United States

    Disclosures

    Received fees for advisory board participation and/or consulting from: Accure; Atara Biotherapeutics; Biogen; Bristol Myers Squibb/Celgene/Receptos; EMD Serono (Merck KGaA); GlaxoSmithKline, Gossamer, Janssen/Actelion, Medimmune, Novartis, Roche/Genentech; Sanofi-Genzyme.
    Received grant support to the University of Pennsylvania from Biogen Idec; EMD Serono (Merck KGaA); Novartis; Roche/Genentech.

    Will be discussing investigational uses of agents for MS in his presentation.

Faculty

  • Wallace J. Brownlee, MBChB, PhD, FRACP

    Consultant Neurologist,
    Cleveland Clinic London
    Consultant Neurologist and MS Specialist
    National Hospital for Neurology and Neurosurgery
    Consultant Neurologist and Honorary Associate Professor of Neurology
    University College London Hospitals NHS Foundation Trust
    London, United Kingdom

    Disclosures

    Received fees for consulting from: Biogen; EMD Serono (Merck KGaA); Janssen; Novartis; Roche; Sanofi.
    Received compensation for serving as an Editorial Advisory Board Member for Sage.

    Will be discussing investigational uses of agents for MS.

  • Anne H. Cross, MD

    Professor of Neurology
    Manny and Rosalyn Rosenthal - Dr John Trotter MS Chair in Neuroimmunology
    Washington University School of Medicine in St Louis
    St Louis, Missouri, United States

    Disclosures

    Received fees for advisory board participation and/or consulting from: Biogen; Bristol Myers Squibb; EMD Serono (Merck KGaA); Genentech/Roche; Greenwich Biosciences; Horizon; Janssen (Johnson & Johnson); Novartis; Octave; TG Therapeutics.

    Will be discussing investigational uses of agents for MS in her presentation.

  • Jiwon Oh, MD, PhD, FRPC

    Associate Professor
    University of Toronto
    Staff Neurologist and Medical Director
    Barlo MS Centre
    St Michael’s Hospital
    Toronto, Ontario, Canada

    Disclosures

    Received fees for advisory board participation and/ or consulting from: Biogen Idec; Eli Lilly; EMD Serono (Merck KGaA); Novartis; Roche; Sanofi Genzyme.
    Received research/ grant support from: Biogen Idec; Roche.

    Will be discussing investigational uses of agents for MS.

Executive Committee, CME and CNE Committee, Planning Committee, Curriculum Committee Members
Content managers/members of the CME, planning, executive and curriculum committees, of Letters & Sciences and PACE report no relationships with ineligible companies to disclose.

Michele Nichols, PharmD (External Content Reviewer)
Has no relevant commercial/financial relationships.

Victoria Rosal-Greif, RN, MA (External Content Reviewer)
Has no relevant commercial/financial relationships.


Accreditation Statements

Jointly provided by Letters & Sciences and Partners for Advancing Clinical Education (PACE).

L&S

PACE

Interprofessional Continuing Education

In support of improving patient care, this activity has been planned and implemented by Partners for Advancing Clinical Education (PACE) and Letters & Sciences. PACE is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    For Physicians

  • PACE designates this live activity for a maximum of 1.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Contact This Provider

For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]


Instructions for Participation and Credit

There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 80% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read the target audience, learning objectives, and author disclosures.
  2. Study the educational content online or printed out.
  3. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. In addition, you must complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period you can print out the tally as well as the certificates from the CME/CE Tracker.

*The credit that you receive is based on your user profile.

CME

Targeting Pathways of Disease Progression in Early Multiple Sclerosis

Authors: Amit Bar-Or, MD, FRCPC, Chair; Wallace J. Brownlee, MBChB, PhD, FRACP; Anne H. Cross, MD; Jiwon Oh, MD, PhD, FRPCFaculty and Disclosures

CME Released: 6/30/2023

Valid for credit through: 6/30/2024, 11:59 PM EST

processing....

Please answer the questions that appear during the activity: Choose an answer, scroll down, and click “Submit.” See responses, scroll down, and click “Continue.”

  • Print