Tuesday, December 5, 2023
Medscape, LLC requires every individual in a position to control educational content to disclose all financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.
All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated. Others involved in the planning of this activity have no relevant financial relationships.
Disclosures for additional planners can be found here.
Associate Professor
Medical College of Wisconsin
Brookfield, Wisconsin
This activity has been peer reviewed and the reviewer has no relevant financial relationships.
Physicians - maximum of 1.00 AMA PRA Category 1 Credit(s)™
ABIM Diplomates - maximum of 1.00 ABIM MOC points
This activity is intended for hematologists/oncologists, pathologists, and other healthcare professionals on the oncology care team who manage patients with MCL.
The goal of this activity is for learners to be better able to improve their skills and confidence in managing patients with R/R MCL to optimize clinical outcomes.
Upon completion of this activity, participants will:
Medscape, LLC requires every individual in a position to control educational content to disclose all financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.
All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated. Others involved in the planning of this activity have no relevant financial relationships.
Disclosures for additional planners can be found here.
Associate Professor
Medical College of Wisconsin
Brookfield, Wisconsin
This activity has been peer reviewed and the reviewer has no relevant financial relationships.
Developed through a collaboration between The Leukemia & Lymphoma Society and Medscape Oncology.
Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.
College of Family Physicians of Canada Mainpro+® participants may claim certified credits for any AMA PRA Category 1 credit(s)™, up to a maximum of 50 credits per five-year cycle. Any additional credits are eligible as non-certified credits. College of Family Physicians of Canada (CFPC) members must log into Mainpro+® to claim this activity.
Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.
For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]
There are no fees for participating in or receiving credit for this online educational activity. For information on applicability
and acceptance of continuing education credit for this activity, please consult your professional licensing board.
This activity is designed to be completed within the time designated on the title page; physicians should claim only those
credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the
activity online during the valid credit period that is noted on the title page. To receive
AMA PRA Category 1 Credit™, you must receive a minimum score of 75% on the post-test.
Follow these steps to earn CME/CE credit*:
You may now view or print the certificate from your CME/CE Tracker. You may print the certificate but you cannot alter it.
Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period you can print
out the tally as well as the certificates from the CME/CE Tracker.
*The credit that you receive is based on your user profile.
CME / ABIM MOC Released: 6/27/2023
Valid for credit through: 6/27/2024, 11:59 PM EST
processing....
 |
Kaye is a 72-year-old retired real estate agent who has been married for 40 years and has 3 adult children. She has a history of atrial fibrillation and chronic obstructive pulmonary disease (COPD). She initially presented to the emergency department 1 year ago with difficulty speaking, and her family was concerned that she was having a stroke. Evaluation and imaging ruled out a stroke but showed significant lymphadenopathy and swelling of her tonsils and sinus area. Her white blood cell (WBC) count was low, and lactate dehydrogenase (LDH) was elevated. Ultrasound-guided biopsy and a full hematologic workup led to a diagnosis of mantle cell lymphoma (MCL) -- TP53 wild type, non-blastoid histology.
Kaye began first-line bendamustine plus rituximab (BR) and completed 6 cycles in total, with the course complicated by hospitalization during cycle 1 due to a pulmonary embolism and worsening of her atrial fibrillation. A positron emission tomography (PET) scan following completion of BR showed residual disease in her tonsils, so she underwent tonsillectomy, which demonstrated small focus of MCL. A postprocedure PET was negative following surgery. She was placed on close observation with no signs of progressive disease. Twelve months after her tonsillectomy, her PET scan now shows increasing lymphadenopathy suggestive of relapse and biopsy confirms recurrent MCL. Her most recent workup is summarized in Table 1.
Table 1. Kaye’s Workup
|
Results |
|
|---|---|
|
Demographics/patient information |
|
|
Personal and family medical history |
|
|
Physical examination |
|
|
Bloodwork |
|
|
PET/CT |
|
|
Biopsy analysis |
|
BMI, body mass index; BP, blood pressure; CT, computed tomography; ECOG PS, Eastern Cooperative Oncology Group performance status; 18F-FDG, ¹⁸F-fluorodeoxyglucose; HR, heart rate; RBC, red blood cell.
You sit down with Kaye and her husband and discuss her treatment options now that her disease has progressed.
