Medscape, LLC requires every individual in a position to control educational content to disclose all financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated. Others involved in the planning of this activity have no relevant financial relationships.

Faculty

Vladimir Maletic, MD, MS

Clinical Professor of Psychiatry
USC School of Medicine
Greenville, South Carolina

Disclosures

Vladimir Maletic, MD, MS, has the following relevant financial relationships:
Consultant or advisor for: AbbVie, Inc./Allergan; ACADIA Pharmaceuticals Inc.; Alfasigma USA, Inc.; Alkermes, Inc.; Biogen; Corium International, Inc.; Intra-Cellular Therapies, Inc.; Ironshore Pharmaceuticals Inc.; Janssen Pharmaceuticals; Lundbeck, Inc.; Jazz Pharmaceuticals, Inc.; Neurelis, Inc.; Neumora; Noven Pharmaceuticals, Inc; Otsuka Pharmaceutical Co., Ltd.; Relmada Therapeutics, Inc.; Sage Pharmaceuticals; Sunovion Pharmaceuticals Inc.; Supernus Pharmaceuticals, Inc.; Takeda Pharmaceuticals North America, Inc.
Speaker or member of speakers bureau for: AbbVie, Inc.; ACADIA Pharmaceuticals Inc.; Alfasigma USA, Inc.; Alkermes, Inc.; Axsome Therapeutics, Inc.; Corium International, Inc.; Eisai, Inc.; Ironshore Pharmaceuticals Inc.; Intra-Cellular Therapies, Inc.; Janssen Pharmaceuticals; Lundbeck, Inc.; Otsuka Pharmaceutical Co., Ltd.; Sunovion Pharmaceuticals Inc.; Supernus Pharmaceuticals, Inc.; Takeda Pharmaceuticals North America, Inc.

Leslie Citrome, MD, MPH

Clinical Professor
Psychiatry and Behavioral Sciences
New York Medical College
Valhalla, New York

Disclosures

Leslie Citrome, MD, MPH, has the following relevant financial relationships:
Consultant or advisor for: AbbVie, Inc./Allergan; ACADIA Pharmaceuticals Inc.; Adamas Pharmaceuticals, Inc.; Alkermes, Inc.; Angelini; Astellas Pharma, Inc.; Avanir Pharmaceuticals; Axsome Therapeutics, Inc.; BioXcel Therapeutics; Boehringer Ingelheim Pharmaceuticals, Inc.; Cadent Therapeutics; Cerevel Therapeutics; Clinilabs Inc.; COMPASS; Eisai, Inc.; Enteris BioPharma; HLS Therapeutics; Idorsia Pharmaceuticals, Ltd.; INmuneBIO; Impel NeuroPharma, Inc.; Intra-Cellular Therapies, Inc.; Janssen Pharmaceuticals; Karuna Therapeutics; Lundbeck, Inc.; Lyndra Therapeutics; MedAvante-ProPhase; Marvin; Merck & Co., Inc.; Mitsubishi Tanabe Pharma Corporation; Neurocrine Biosciences, Inc.; Neurelis, Inc.; Novartis Pharmaceuticals; Noven Pharmaceuticals, Inc.; Otsuka Pharmaceutical Co., Ltd.; Ovid Therapeutics; Praxis Precision Medicines; Recordati; Relmada Therapeutics, Inc.; Reviva Pharmaceuticals Inc.; Sage Pharmaceuticals; Sunovion Pharmaceuticals Inc.; Supernus Pharmaceuticals, Inc.; Teva Pharmaceutical Industries Ltd.
Speaker or member of speakers bureau for: AbbVie, Inc./Allergan; ACADIA Pharmaceuticals Inc.; Alkermes, Inc.; Angelini; Axsome Therapeutics, Inc.; BioXcel Therapeutics; Eisai, Inc.; Idorsia Pharmaceuticals, Ltd.; Intra-Cellular Therapies, Inc.; Janssen Pharmaceuticals; Lundbeck, Inc.; Neurocrine Biosciences, Inc.; Noven Pharmaceuticals, Inc.; Otsuka Pharmaceutical Co., Ltd.; Recordati; Sage Pharmaceuticals; Sunovion Pharmaceuticals Inc.; Takeda Pharmaceuticals North America, Inc.; Teva Pharmaceutical Industries Ltd.
Owns stock (publicly traded) in: Bristol Myers Squibb Company; Lilly; Johnson & Johnson; Merck & Co., Inc.; Pfizer, Inc.

Joseph F. Goldberg, MD

Clinical Professor of Psychiatry
Icahn School of Medicine at Mount Sinai
New York, New York

Disclosures

Joseph F. Goldberg, MD, has the following relevant financial relationships:
Consultant or advisor for: BioXcel Therapeutics; Neumora; Neurelis, Inc.; Otsuka Pharmaceutical Co., Ltd.; Sage Pharmaceuticals; Sunovion Pharmaceuticals Inc.
Speaker or member of speakers bureau for: AbbVie, Inc.; Alkermes, Inc.; Axsome Therapeutics, Inc.; Intra-Cellular Therapies, Inc.

Editor

Clinton W. Wright, PharmD, BCPP

Medical Education Director, Medscape, LLC

Disclosures

Clinton W. Wright, PharmD, BCPP, has no relevant financial relationships.

Compliance Reviewer

Stephanie Corder, ND, RN, CHCP

Associate Director, Accreditation and Compliance, Medscape, LLC

Disclosures

Stephanie Corder, ND, RN, CHCP, has no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has no relevant financial relationships.

CME / ABIM MOC

New Mechanisms in Major Depressive Disorder: What the Busy Clinician Needs to Know

Authors: Vladimir Maletic, MD, MS; Leslie Citrome, MD, MPH; Joseph F. Goldberg, MD
CME / ABIM MOC Released: 6/22/2023
Valid for credit through: 6/22/2024, 11:59 PM EST

Start Activity

Credits Available

Physicians - maximum of 0.75 AMA PRA Category 1 Credit(s)™

ABIM Diplomates - maximum of 0.75 ABIM MOC points

You Are Eligible For
- Letter of Completion
- ABIM MOC points

Target Audience and Goal Statement

This activity is intended for psychiatrists, primary care physicians (PCPs), nurses, nurse practitioners (NPs), and other clinicians who treat patients with major depressive disorder (MDD).

The goal of this activity is to help clinicians be better able to individualize treatment plans for their patients with MDD.

Upon completion of this activity, participants will:

Have increased knowledge regarding the
- Mechanisms of action (MOAs) of novel and emerging agents for the treatment of MDD
Demonstrate greater confidence in their ability to
- Identify how novel therapeutic approaches may address unmet clinical needs in MDD treatment

Disclosures

Faculty

Vladimir Maletic, MD, MS

Clinical Professor of Psychiatry
USC School of Medicine
Greenville, South Carolina

Disclosures

Vladimir Maletic, MD, MS, has the following relevant financial relationships:
Consultant or advisor for: AbbVie, Inc./Allergan; ACADIA Pharmaceuticals Inc.; Alfasigma USA, Inc.; Alkermes, Inc.; Biogen; Corium International, Inc.; Intra-Cellular Therapies, Inc.; Ironshore Pharmaceuticals Inc.; Janssen Pharmaceuticals; Lundbeck, Inc.; Jazz Pharmaceuticals, Inc.; Neurelis, Inc.; Neumora; Noven Pharmaceuticals, Inc; Otsuka Pharmaceutical Co., Ltd.; Relmada Therapeutics, Inc.; Sage Pharmaceuticals; Sunovion Pharmaceuticals Inc.; Supernus Pharmaceuticals, Inc.; Takeda Pharmaceuticals North America, Inc.
Speaker or member of speakers bureau for: AbbVie, Inc.; ACADIA Pharmaceuticals Inc.; Alfasigma USA, Inc.; Alkermes, Inc.; Axsome Therapeutics, Inc.; Corium International, Inc.; Eisai, Inc.; Ironshore Pharmaceuticals Inc.; Intra-Cellular Therapies, Inc.; Janssen Pharmaceuticals; Lundbeck, Inc.; Otsuka Pharmaceutical Co., Ltd.; Sunovion Pharmaceuticals Inc.; Supernus Pharmaceuticals, Inc.; Takeda Pharmaceuticals North America, Inc.

Leslie Citrome, MD, MPH

Clinical Professor
Psychiatry and Behavioral Sciences
New York Medical College
Valhalla, New York

Disclosures

Leslie Citrome, MD, MPH, has the following relevant financial relationships:
Consultant or advisor for: AbbVie, Inc./Allergan; ACADIA Pharmaceuticals Inc.; Adamas Pharmaceuticals, Inc.; Alkermes, Inc.; Angelini; Astellas Pharma, Inc.; Avanir Pharmaceuticals; Axsome Therapeutics, Inc.; BioXcel Therapeutics; Boehringer Ingelheim Pharmaceuticals, Inc.; Cadent Therapeutics; Cerevel Therapeutics; Clinilabs Inc.; COMPASS; Eisai, Inc.; Enteris BioPharma; HLS Therapeutics; Idorsia Pharmaceuticals, Ltd.; INmuneBIO; Impel NeuroPharma, Inc.; Intra-Cellular Therapies, Inc.; Janssen Pharmaceuticals; Karuna Therapeutics; Lundbeck, Inc.; Lyndra Therapeutics; MedAvante-ProPhase; Marvin; Merck & Co., Inc.; Mitsubishi Tanabe Pharma Corporation; Neurocrine Biosciences, Inc.; Neurelis, Inc.; Novartis Pharmaceuticals; Noven Pharmaceuticals, Inc.; Otsuka Pharmaceutical Co., Ltd.; Ovid Therapeutics; Praxis Precision Medicines; Recordati; Relmada Therapeutics, Inc.; Reviva Pharmaceuticals Inc.; Sage Pharmaceuticals; Sunovion Pharmaceuticals Inc.; Supernus Pharmaceuticals, Inc.; Teva Pharmaceutical Industries Ltd.
Speaker or member of speakers bureau for: AbbVie, Inc./Allergan; ACADIA Pharmaceuticals Inc.; Alkermes, Inc.; Angelini; Axsome Therapeutics, Inc.; BioXcel Therapeutics; Eisai, Inc.; Idorsia Pharmaceuticals, Ltd.; Intra-Cellular Therapies, Inc.; Janssen Pharmaceuticals; Lundbeck, Inc.; Neurocrine Biosciences, Inc.; Noven Pharmaceuticals, Inc.; Otsuka Pharmaceutical Co., Ltd.; Recordati; Sage Pharmaceuticals; Sunovion Pharmaceuticals Inc.; Takeda Pharmaceuticals North America, Inc.; Teva Pharmaceutical Industries Ltd.
Owns stock (publicly traded) in: Bristol Myers Squibb Company; Lilly; Johnson & Johnson; Merck & Co., Inc.; Pfizer, Inc.

Joseph F. Goldberg, MD

Clinical Professor of Psychiatry
Icahn School of Medicine at Mount Sinai
New York, New York

Disclosures

Joseph F. Goldberg, MD, has the following relevant financial relationships:
Consultant or advisor for: BioXcel Therapeutics; Neumora; Neurelis, Inc.; Otsuka Pharmaceutical Co., Ltd.; Sage Pharmaceuticals; Sunovion Pharmaceuticals Inc.
Speaker or member of speakers bureau for: AbbVie, Inc.; Alkermes, Inc.; Axsome Therapeutics, Inc.; Intra-Cellular Therapies, Inc.

Editor

Clinton W. Wright, PharmD, BCPP

Medical Education Director, Medscape, LLC

Disclosures

Clinton W. Wright, PharmD, BCPP, has no relevant financial relationships.

Compliance Reviewer

Stephanie Corder, ND, RN, CHCP

Associate Director, Accreditation and Compliance, Medscape, LLC

Disclosures

Stephanie Corder, ND, RN, CHCP, has no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has no relevant financial relationships.

Accreditation Statements

In support of improving patient care, Medscape, LLC is jointly accredited with commendation by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

For Physicians

Medscape, LLC designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.75 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

Contact This Provider

For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]

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There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 70% on the post-test.

Follow these steps to earn CME/CE credit*:

Read about the target audience, learning objectives, and author disclosures.
Study the educational content online or print it out.
Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate, but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period, you can print out the tally as well as the certificates from the CME/CE Tracker.

*The credit that you receive is based on your user profile.

From Medscape Education Psychiatry & Mental Health

CME / ABIM MOC

New Mechanisms in Major Depressive Disorder: What the Busy Clinician Needs to Know

Authors: Vladimir Maletic, MD, MS; Leslie Citrome, MD, MPH; Joseph F. Goldberg, MDFaculty and Disclosures

CME / ABIM MOC Released: 6/22/2023

Valid for credit through: 6/22/2024, 11:59 PM EST

processing....

Contents of This CME Activity

Clinician Handout

To start this activity, please assess your clinical knowledge by completing the brief survey at the bottom. Answering these questions again after the activity will allow you to see what you learned and to compare your answers with those of your peers.

Standard of Care

Can you treat depression without monoamines?
Vladimir Maletic, MD, MS

Novel MOAs: NMDA Receptor Antagonists

What role does glutamate play in the treatment of depression?
Leslie Citrome, MD, MPH

Novel MOAs: Psychedelics and Other Agents

It's all about neuroplasticity!
Joseph F. Goldberg, MD

Novel MOAs: GABA Receptor Modulators

Leaving out benzodiazepines in the GABA story!
Leslie Citrome, MD, MPH

Educational Impact Challenge

The goal of this activity is to help clinicians be better able to individualize treatment plans for their patients with MDD.

Before you begin this activity, please assess your clinical knowledge by completing this brief survey. Answering these questions again after the activity will allow you to see what you learned and to compare your answers with those of your peers.

Page 1 of 7

CME / ABIM MOC Information Download Slides

Activity Transcript

PDF Downloads

Clinician Handout

Print
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Activity Transcript

Disclaimer

The educational activity presented above may involve simulated, case-based scenarios. The patients depicted in these scenarios are fictitious and no association with any actual patient, whether living or deceased, is intended or should be inferred.

The material presented here does not necessarily reflect the views of Medscape, LLC, or any individuals or commercial entities that support companies that support educational programming on medscape.org. These materials may include discussion of therapeutic products that have not been approved by the US Food and Drug Administration, off-label uses of approved products, or data that were presented in abstract form. These data should be considered preliminary until published in a peer-reviewed journal. Readers should verify all information and data before treating patients or employing any therapies described in this or any educational activity. A qualified healthcare professional should be consulted before using any therapeutic product discussed herein.

Faculty and Disclosures

Faculty

Vladimir Maletic, MD, MS ​

Leslie Citrome, MD, MPH​

Joseph F. Goldberg, MD​

Editor

Clinton W. Wright, PharmD, BCPP

Compliance Reviewer

Stephanie Corder, ND, RN, CHCP

Peer Reviewer

CME / ABIM MOC

New Mechanisms in Major Depressive Disorder: What the Busy Clinician Needs to Know

Credits Available

You Are Eligible For

Target Audience and Goal Statement

Disclosures

Faculty

Vladimir Maletic, MD, MS ​

Leslie Citrome, MD, MPH​

Joseph F. Goldberg, MD​

Editor

Clinton W. Wright, PharmD, BCPP

Compliance Reviewer

Stephanie Corder, ND, RN, CHCP

Peer Reviewer

Accreditation Statements

For Physicians

Instructions for Participation and Credit

New Mechanisms in Major Depressive Disorder: What the Busy Clinician Needs to Know

Contents of This CME Activity

Clinician Handout

Standard of Care

Novel MOAs: NMDA Receptor Antagonists

Novel MOAs: Psychedelics and Other Agents

Novel MOAs: GABA Receptor Modulators

Educational Impact Challenge

PDF Downloads

Vladimir Maletic, MD, MS

Leslie Citrome, MD, MPH

Joseph F. Goldberg, MD

Vladimir Maletic, MD, MS

Leslie Citrome, MD, MPH

Joseph F. Goldberg, MD