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Talking With Parents of Children With Tuberous Sclerosis Complex (TSC)–Related Seizures About Treatment Options

  • Authors: Elizabeth A. Thiele, MD, PhD
  • CME Released: 5/9/2023
  • Valid for credit through: 5/9/2024
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  • Credits Available

    Physicians - maximum of 0.50 AMA PRA Category 1 Credit(s)™

    You Are Eligible For

    • Letter of Completion

Target Audience and Goal Statement

This activity is intended for neurologists, pediatricians, and primary care practitioners.

The goal of this activity is for learners to be better able to speak to caregivers/patients about antiseizure options for patients with TSC.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Goals of treatment for seizures associated with TSC
  • Have greater competence related to
    • Identification of appropriate antiseizure medicines for the management of TSC-related seizures that takes into account patient-related factors and preferences


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All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated. Others involved in the planning of this activity have no relevant financial relationships.

Disclosures for additional planners can be found here.


  • Elizabeth A. Thiele, MD, PhD

    Director, Pediatric Epilepsy Program
    Massachusetts General Hospital
    Herscot Center for Tuberous Sclerosis Complex
    Boston, Massachusetts


    Elizabeth A. Thiele, MD, PhD, has the following relevant financial relationships:
    Consultant or advisor for: Aditum; Azurity; BridgeBio; GW Pharmaceuticals/Jazz Pharmaceuticals, Inc.; LivaNova; Marinus Pharmaceuticals, Inc.; Nobelpharma; Radius Health, Inc.; Stoke Therapeutics; Zogenix, Inc.
    Research funding from: GW Pharmaceuticals/Jazz Pharmaceuticals, Inc.; Stoke Therapeutics; Zogenix, Inc.
    Contracted researcher for: GW Pharmacueticals/Jazz Pharmaceuticals, Inc.; Zogenix, Inc.


  • Frances McFarland, PhD, MA

    Medical Education Director, Medscape, LLC


    Frances McFarland, PhD, MA, has no relevant financial relationships.

  • Megan Breuer, PhD

    Medical Writer, Medscape, LLC


    Megan Breuer, PhD, has the following relevant financial relationships:
    Consultant or advisor for: Paratek Pharmaceuticals, Inc. (former)

Compliance Reviewer

  • Stephanie Corder, ND, RN, CHCP

    Associate Director, Accreditation and Compliance, Medscape, LLC


    Stephanie Corder, ND, RN, CHCP, has no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has no relevant financial relationships.

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In support of improving patient care, Medscape, LLC is jointly accredited with commendation by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    The European Union of Medical Specialists (UEMS)-European Accreditation Council for Continuing Medical Education (EACCME) has an agreement of mutual recognition of continuing medical education (CME) credit with the American Medical Association (AMA). European physicians interested in converting AMA PRA Category 1 Credit™ into European CME credit (ECMEC) should contact the UEMS (

    College of Family Physicians of Canada Mainpro+® participants may claim certified credits for any AMA PRA Category 1 credit(s)™, up to a maximum of 50 credits per five-year cycle. Any additional credits are eligible as non-certified credits. College of Family Physicians of Canada (CFPC) members must log into Mainpro+® to claim this activity.

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This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 70% on the post-test.

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Talking With Parents of Children With Tuberous Sclerosis Complex (TSC)–Related Seizures About Treatment Options

Authors: Elizabeth A. Thiele, MD, PhDFaculty and Disclosures

CME Released: 5/9/2023

Valid for credit through: 5/9/2024


This clinic presents 3 cases. In the first case, Maria is the mother of Ronald, a 9-year-old child who presented with a focal seizure a week ago. After performing a physical exam and imaging studies, the doctor is ready to talk with Maria about Ronald’s diagnosis and possible treatment plan. In the second case, the doctor is meeting with Arthur, who is the father of Bella, a 7-month-old baby who has been experiencing infantile spasms and focal seizures, and has recently been diagnosed with tuberous sclerosis complex. In the third case, Melody is the mother of a 4-year-old child, Thomas, who has tuberous sclerosis complex after experiencing infantile spasms as a baby. However, he has not been responding to his current treatment, and the doctor and Melody are now discussing how to proceed.

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