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PCSK9 Inhibitors: Tips and Tricks for Improving Access and Adherence

  • Authors: Marc S. Sabatine, MD, MPH; Joyce L. Ross, CRNP, CLS; Joseph Saseen, PharmD
  • CME / ABIM MOC Released: 3/30/2023
  • Valid for credit through: 3/30/2024
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  • Credits Available

    Physicians - maximum of 0.50 AMA PRA Category 1 Credit(s)™

    ABIM Diplomates - maximum of 0.50 ABIM MOC points

    You Are Eligible For

    • Letter of Completion
    • ABIM MOC points

Target Audience and Goal Statement

This activity is intended for cardiologists, primary care physicians, nurses, nurse practitioners, physician assistants, and other clinicians who treat patients with dyslipidemia.

The goal of this activity is for learners to be better able to improve knowledge of barriers to the use of PCSK9 inhibitors and improve care for patients with dyslipidemia.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Background and gaps in use of PCSK9 inhibitors in practice
    • Strategies for improving access and adherence to PCSK9 inhibitors
  • Have greater competence related to
    • Overcoming barriers to optimal PCSK9 inhibitor use in practice


Medscape, LLC requires every individual in a position to control educational content to disclose all financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated. Others involved in the planning of this activity have no relevant financial relationships.


  • Marc S. Sabatine, MD, MPH

    TIMI Study Group
    Brigham and Women's Hospital
    Harvard Medical School
    Boston, Massachusetts


    Marc S. Sabatine, MD, MPH, has the following relevant financial relationships:
    Consultant or advisor for: Althera; Amgen; Anthos Therapeutics; AstraZeneca; Beren Therapeutics; Boehringer Ingelheim Pharmaceuticals, Inc.; FibroGen, Inc.; Intarcia Therapeutics, Inc.; Merck; Moderna, Inc.; Novo Nordisk; Precision Biosciences; Silence Therapeutics
    Research funding from: Abbott; Amgen; Anthos Therapeutics; AstraZeneca; Daiichi Sankyo, Inc.; Eisai Inc.; Intarcia Therapeutics, Inc.; Ionis Pharmaceuticals; Merck; Novartis; Pfizer, Inc.
    Other: Member of TIMI Study Group which received grant support from: ARCA Biopharma, Inc.; Janssen Research and Development, LLC; Pfizer, Inc.; Regeneron Pharmaceuticals, Inc.; Roche; Siemens Healthcare Diagnostics Inc.; Softcell Medical Limited; Zora Biosciences

  • Joyce L. Ross, CRNP, CLS

    Nurse Practitioner
    Clinical Associate
    Past President of NLA
    University of Pennsylvania
    Philadelphia, Pennsylvania


    Joyce L. Ross, CRNP, CLS, has no relevant financial relationships.

  • Joseph Saseen, PharmD

    Associate Dean for Clinical Affairs
    Professor, Department of Clinical Pharmacy; Professor, Department of Family Medicine
    Skaggs School of Pharmacy and Pharmaceutical Sciences
    University of Colorado Anschutz Medical Campus
    Past President of NLA
    Aurora, Colorado


    Joseph Saseen, PharmD, has no relevant financial relationships.


  • Joy P. Marko, MS, APN-C, CCMEP

    Senior Medical Education Director, Medscape, LLC


    Joy P. Marko, MS, APN-C, CCMEP, has no relevant financial relationships.

Compliance Reviewer

  • Leigh Schmidt, MSN, RN, CNE, CHCP

    Associate Director, Accreditation and Compliance, Medscape, LLC


    Leigh Schmidt, MSN, RN, CNE, CHCP, has no relevant financial relationships.

Accreditation Statements

Developed through a collaboration between the American College of Cardiology Foundation and Medscape Education.

In support of improving patient care, Medscape, LLC is jointly accredited with commendation by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 0.50  AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.50 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

    The European Union of Medical Specialists (UEMS)-European Accreditation Council for Continuing Medical Education (EACCME) has an agreement of mutual recognition of continuing medical education (CME) credit with the American Medical Association (AMA). European physicians interested in converting AMA PRA Category 1 Credit™ into European CME credit (ECMEC) should contact the UEMS (

    College of Family Physicians of Canada Mainpro+® participants may claim certified credits for any AMA PRA Category 1 credit(s)™, up to a maximum of 50 credits per five-year cycle. Any additional credits are eligible as non-certified credits. College of Family Physicians of Canada (CFPC) members must log into Mainpro+® to claim this activity.

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For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]

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This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 70% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read about the target audience, learning objectives, and author disclosures.
  2. Study the educational content online or print it out.
  3. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

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PCSK9 Inhibitors: Tips and Tricks for Improving Access and Adherence

Authors: Marc S. Sabatine, MD, MPH; Joyce L. Ross, CRNP, CLS; Joseph Saseen, PharmDFaculty and Disclosures

CME / ABIM MOC Released: 3/30/2023

Valid for credit through: 3/30/2024


Contents of This CME Activity

All sections of this activity are required for credit.

Gaps and Challenges

Do you know all you need to know about PCSK9 inhibitors?
Marc S. Sabatine, MD, MPH

Solutions for Patient Adherence

Are you ready to take a deep dive into improving patient adherence?
Joyce L. Ross, CRNP, CLS

Solutions for Improved Access and Insurance Coverage

Need some advice to increase prior authorization approval?
Joseph Saseen, PharmD

Learning Feedback Questions

Please answer these questions to complement your learning experience.

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