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To Test or Not: A Call to Action for Improving Alpha-1 Antitrypsin Deficiency Management

  • Authors: Umur Hatipoğlu, MD, MBA
  • CME / CE Released: 4/4/2023
  • Valid for credit through: 4/4/2024, 11:59 PM EST
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  • Credits Available

    Physicians - maximum of 0.25 AMA PRA Category 1 Credit(s)™

    Nurses - 0.25 ANCC Contact Hour(s) (0 contact hours are in the area of pharmacology)

    You Are Eligible For

    • Letter of Completion

Target Audience and Goal Statement

This activity is intended for pulmonologists, allergists/clinical immunologists, and other clinicians who treat patients with AATD.

The goal of this activity is for learners to be better able to incorporate specific strategies to improve testing for AATD into clinical practice, and counsel patients on testing and early diagnosis.

Upon completion of this activity, participants will:

  • Have greater competence related to
    • Incorporating strategies to improve testing for AATD
  • Self-assess learning needs related to
    • AATD testing guidelines


In accordance with the Standards for Integrity and Independence issued by the Accreditation Council for Continuing Medical Education (ACCME), The Cleveland Clinic Center for Continuing Education mitigates all relevant conflicts of interest to ensure CME activities are free of commercial bias. All other reviewers and staff report no relevant financial relationships which, in the context of their contributions, could be perceived as a potential conflict of interest.

Disclosures for additional planners can be found here.


  • Umur Hatipoğlu, MD, MBA

    Professor of Medicine
    Cleveland Clinic Lerner College of Medicine
    Case Western Reserve University School of Medicine
    Cleveland, Ohio


    Umur Hatipoğlu, MD, MBA, has no relevant financial relationships.

Course Director

  • James K. Stoller, MD, MS

    Professor and Chairman, Education Institute, Cleveland Clinic
    Jean Wall Bennett Professor of Medicine
    Samson Global Leadership Endowed Chair


    James K. Stoller, MD, MS, has the following relevant financial relationships:
    Consultant or advisor for: 4DMT; 23andMe; CSL Behring; Dicerna Pharmaceuticals; Grifols; Inhibrx; Korro; Takeda; Vertex Pharmaceuticals Incorporated
    Speaker or member of speakers bureau for: 23andMe; CSL Behring; Grifols
    Research funding from: 23andMe


  • Karen Badal, MD, MPH

    Senior Medical Education Director, Medscape, LLC


    Karen Badal, MD, MPH, has no relevant financial relationships.

  • Kevan H. Chambers​, ​FRSPH​

    Medical Writer, Medscape, LLC


    Kevan H. Chambers​, ​FRSPH​, has no relevant financial relationships.

Compliance Reviewer

  • Leigh Schmidt, MSN, RN, CNE, CHCP

    Associate Director, Accreditation and Compliance, Medscape, LLC


    ​Leigh Schmidt, MSN, RN, CNE, CHCP, has no relevant financial relationships.​​​​ 

Nurse Planner

  • Cynthia Willis, RN, DNP, MBA, CMSRN


    Cynthia Willis, RN, DNP, MBA, CMSRN, has no relevant financial relationships. 

Accreditation Statements

Developed through a partnership between Medscape and ​Alpha-1 Foundation and Cleveland Clinic​.

Cleveland Clinic

In support of improving patient care, Cleveland Clinic is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    For Physicians

  • Cleveland Clinic designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Contact This Provider

    For Nurses

  • Awarded 0.25 contact hour(s) of nursing continuing professional development for RNs and APNs; 0.00 contact hours are in the area of pharmacology.

    Contact This Provider

For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]

Instructions for Participation and Credit

There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 70% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read about the target audience, learning objectives, and author disclosures.
  2. Study the educational content online or print it out.
  3. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate, but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period, you can print out the tally as well as the certificates from the CME/CE Tracker.

*The credit that you receive is based on your user profile.


To Test or Not: A Call to Action for Improving Alpha-1 Antitrypsin Deficiency Management

Authors: Umur Hatipoğlu, MD, MBAFaculty and Disclosures

CME / CE Released: 4/4/2023

Valid for credit through: 4/4/2024, 11:59 PM EST



The goals of continuing medical education (CME) and professional development are to acquire and retain knowledge that will enhance clinical practice and improve patient outcomes. The following self-assessment survey is offered for CME credit and is designed to test your current knowledge and skills related to the diagnosis and management of patients with alpha-1 antitrypsin deficiency (AATD).

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