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All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated. Others involved in the planning of this activity have no relevant financial relationships.

Faculty

Sonata Jodele, MD

Research Professor
Department of Pediatrics
Division of Bone Marrow Transplantation and Immune Deficiency
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States

Disclosures

Sonata Jodele, MD, has the following relevant financial relationships:
Consultant or advisor for: Alexion Pharmaceuticals, Inc.; Omeros Corporation; SOBI
Speaker or member of speakers bureau for: Omeros Corporation
Research funding from: Alexion Pharmaceuticals, Inc.
Patent beneficiary of: United States Patent (Jodele, et al). Patent No: US 10,815,296 B2. Issue date: 10/27/2020. "Methods of Treatment of HSCT-Associated Thrombotic Microangiopathy with Eculizumab"

Alessandro Rambaldi, MD

Department of Oncology and Hematology
University of Milan
Bergamo, Italy

Disclosures

Alessandro Rambaldi, MD, has the following relevant financial relationships: Consultant or advisor for: Amgen Inc.; Astellas Pharma, Inc.; Incyte Corporation; Janssen; Jazz Pharmaceuticals, Inc.; Kite Pharma, Inc.-Gilead Sciences, Inc.; Novartis; Omeros Corporation; Pfizer Inc.; Roche

Anthony Sabulski, MD

Instructor
Department of Pediatrics
Division of Bone Marrow Transplantation and Immune Deficiency
Cincinnati Children’s Hospital Medical Center
Cincinnati, Ohio, United States

Disclosures

Anthony Sabulski, MD, has the following relevant financial relationships:
Consultant or advisor for: SOBI

Editor

Heather P. Friedman, MPH

Medical Education Director, Medscape, LLC

Disclosures

Heather P. Friedman, MPH, has no relevant financial relationships.

Compliance Reviewer

Yaisanet Oyola, MD

Associate Director, Accreditation and Compliance, Medscape, LLC

Disclosures

Yaisanet Oyola, MD, has no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has no relevant financial relationships.

CME

Resolving Complications With Complement: Updates on the Management of HSCT-TMA

Authors: Sonata Jodele, MD; Alessandro Rambaldi, MD; Anthony Sabulski, MD
CME Released: 3/20/2023
Valid for credit through: 3/20/2024

Start Activity

Credits Available

Physicians - maximum of 0.75 AMA PRA Category 1 Credit(s)™

You Are Eligible For
- Letter of Completion

Target Audience and Goal Statement

This activity is intended for hematologist/oncologists, transplant specialists, pediatricians, emergency medicine physicians, and other members of the multidisciplinary transplant team.

The goal of this activity is for learners to be better able to diagnose HSCT-TMA and to recognize the evolving role of complement-based therapies in the care of patients with HSCT-TMA.

Upon completion of this activity, participants will:

Have increased knowledge regarding the
- Key clinical trial data evaluating complement-based therapies for the treatment of HSCT-TMA
Have greater competence related to
- Accurately diagnosing HSCT-TMA
- Personalizing treatment decisions for patients with HSCT-TMA
Demonstrate greater confidence in their ability to
- Comprehensively treat patients with HSCT-TMA as part of the multidisciplinary team

Disclosures

Faculty

Sonata Jodele, MD

Research Professor
Department of Pediatrics
Division of Bone Marrow Transplantation and Immune Deficiency
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States

Disclosures

Sonata Jodele, MD, has the following relevant financial relationships:
Consultant or advisor for: Alexion Pharmaceuticals, Inc.; Omeros Corporation; SOBI
Speaker or member of speakers bureau for: Omeros Corporation
Research funding from: Alexion Pharmaceuticals, Inc.
Patent beneficiary of: United States Patent (Jodele, et al). Patent No: US 10,815,296 B2. Issue date: 10/27/2020. "Methods of Treatment of HSCT-Associated Thrombotic Microangiopathy with Eculizumab"

Alessandro Rambaldi, MD

Department of Oncology and Hematology
University of Milan
Bergamo, Italy

Disclosures

Alessandro Rambaldi, MD, has the following relevant financial relationships: Consultant or advisor for: Amgen Inc.; Astellas Pharma, Inc.; Incyte Corporation; Janssen; Jazz Pharmaceuticals, Inc.; Kite Pharma, Inc.-Gilead Sciences, Inc.; Novartis; Omeros Corporation; Pfizer Inc.; Roche

Anthony Sabulski, MD

Instructor
Department of Pediatrics
Division of Bone Marrow Transplantation and Immune Deficiency
Cincinnati Children’s Hospital Medical Center
Cincinnati, Ohio, United States

Disclosures

Anthony Sabulski, MD, has the following relevant financial relationships:
Consultant or advisor for: SOBI

Editor

Heather P. Friedman, MPH

Medical Education Director, Medscape, LLC

Disclosures

Heather P. Friedman, MPH, has no relevant financial relationships.

Compliance Reviewer

Yaisanet Oyola, MD

Associate Director, Accreditation and Compliance, Medscape, LLC

Disclosures

Yaisanet Oyola, MD, has no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has no relevant financial relationships.

Accreditation Statements

Developed through a strategic partnership between the Medical College of Wisconsin (MCW) and Medscape Oncology.

The Medical College of Wisconsin is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

For Physicians

The Medical College of Wisconsin designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Contact This Provider

For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]

Instructions for Participation and Credit

There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 70% on the post-test.

Follow these steps to earn CME/CE credit*:

Read about the target audience, learning objectives, and author disclosures.
Study the educational content online or print it out.
Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate, but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period, you can print out the tally as well as the certificates from the CME/CE Tracker.

*The credit that you receive is based on your user profile.

From Medscape Education Oncology

CME

Resolving Complications With Complement: Updates on the Management of HSCT-TMA

Authors: Sonata Jodele, MD; Alessandro Rambaldi, MD; Anthony Sabulski, MDFaculty and Disclosures

CME Released: 3/20/2023

Valid for credit through: 3/20/2024

processing....

Educational Impact Challenge

The goal of this activity is for learners to be better able to diagnose HSCT-TMA and to recognize the evolving role of complement-based therapies in the care of patients with HSCT-TMA.

Before you begin this activity, please assess your clinical knowledge by completing this brief survey. Answering these questions again after the activity will allow you to see what you learned and to compare your answers with those of your peers.

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Disclaimer

The educational activity presented above may involve simulated, case-based scenarios. The patients depicted in these scenarios are fictitious and no association with any actual patient, whether living or deceased, is intended or should be inferred.

The material presented here does not necessarily reflect the views of Medscape, LLC, or any individuals or commercial entities that support companies that support educational programming on medscape.org. These materials may include discussion of therapeutic products that have not been approved by the US Food and Drug Administration, off-label uses of approved products, or data that were presented in abstract form. These data should be considered preliminary until published in a peer-reviewed journal. Readers should verify all information and data before treating patients or employing any therapies described in this or any educational activity. A qualified healthcare professional should be consulted before using any therapeutic product discussed herein.

Faculty and Disclosures

Faculty

Sonata Jodele, MD

Alessandro Rambaldi, MD

Anthony Sabulski, MD

Editor

Heather P. Friedman, MPH

Compliance Reviewer

Yaisanet Oyola, MD

Peer Reviewer

CME

Resolving Complications With Complement: Updates on the Management of HSCT-TMA

Credits Available

You Are Eligible For

Target Audience and Goal Statement

Disclosures

Faculty

Sonata Jodele, MD

Alessandro Rambaldi, MD

Anthony Sabulski, MD

Editor

Heather P. Friedman, MPH

Compliance Reviewer

Yaisanet Oyola, MD

Peer Reviewer

Accreditation Statements

For Physicians

Instructions for Participation and Credit

Resolving Complications With Complement: Updates on the Management of HSCT-TMA

Educational Impact Challenge