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Disclosures for additional planners can be found here.

Faculty

Elaine C. Wirrell, MD

Professor of Neurology
Divisions of Child and Adolescent Neurology and Epilepsy
Department of Neurology
Chair of Child and Adolescent Neurology
Mayo Clinic
Rochester, Minnesota

Disclosures

Elaine C. Wirrell, MD, has the following relevant financial relationships:
Consultant or advisor for: BioMarin Pharmaceutical, Inc.; Eisai, Inc.
Research funding from: Biocodex; Jazz Pharmaceuticals, Inc.; Marinus Pharmaceuticals; Stoke Therapeutics; Takeda; Zogenix, Inc.

Editors

Frances McFarland, PhD, MA

Medical Education Director, Medscape, LLC

Disclosures

Frances McFarland, PhD, MA, has no relevant financial relationships.

Megan Breuer, PhD

Medical Writer, Medscape, LLC

Disclosures

Megan Breuer, PhD, has the following relevant financial relationships:
Consultant/advisor: Paratek Pharmaceuticals, Inc. (former)
Owns stock (publicly traded) in: Bristol Myers Squibb Company; Johnson and Johnson; Paratek Pharmaceuticals, Inc.; Vertex Pharmaceuticals Inc.

Compliance Reviewer

Leigh Schmidt, MSN, RN, CNE, CHCP

Associate Director, Accreditation and Compliance, Medscape, LLC

Disclosures

Leigh Schmidt, MSN, RN, CNE, CHCP, has no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has no relevant financial relationships.

CME / ABIM MOC

Test Your Expertise in the Diagnosis and Management of Rare Pediatric Epilepsies

Authors: Elaine C. Wirrell, MD
CME / ABIM MOC Released: 3/16/2023
Valid for credit through: 3/16/2024

Start Activity

Credits Available

Physicians - maximum of 1.00 AMA PRA Category 1 Credit(s)™

ABIM Diplomates - maximum of 1.00 ABIM MOC points

You Are Eligible For
- Letter of Completion
- ABIM MOC points

Target Audience and Goal Statement

This activity is intended for neurologists, pediatricians, and psychiatrists.

The goal of this activity is for learners to be better able to accurately diagnose and effectively manage patients with Lennox-Gastaut syndrome (LGS) and Dravet syndrome (DS).

Upon completion of this activity, participants will:

Have greater competence related to
- Selection of appropriate assessment tools for a pediatric patient with seizures
- Accurate diagnosis of a rare pediatric epilepsy
- Selection of an appropriate antiseizure medication (ASM) for the management of a rare pediatric epilepsy

Disclosures

Disclosures for additional planners can be found here.

Faculty

Elaine C. Wirrell, MD

Professor of Neurology
Divisions of Child and Adolescent Neurology and Epilepsy
Department of Neurology
Chair of Child and Adolescent Neurology
Mayo Clinic
Rochester, Minnesota

Disclosures

Elaine C. Wirrell, MD, has the following relevant financial relationships:
Consultant or advisor for: BioMarin Pharmaceutical, Inc.; Eisai, Inc.
Research funding from: Biocodex; Jazz Pharmaceuticals, Inc.; Marinus Pharmaceuticals; Stoke Therapeutics; Takeda; Zogenix, Inc.

Editors

Frances McFarland, PhD, MA

Medical Education Director, Medscape, LLC

Disclosures

Frances McFarland, PhD, MA, has no relevant financial relationships.

Megan Breuer, PhD

Medical Writer, Medscape, LLC

Disclosures

Megan Breuer, PhD, has the following relevant financial relationships:
Consultant/advisor: Paratek Pharmaceuticals, Inc. (former)
Owns stock (publicly traded) in: Bristol Myers Squibb Company; Johnson and Johnson; Paratek Pharmaceuticals, Inc.; Vertex Pharmaceuticals Inc.

Compliance Reviewer

Leigh Schmidt, MSN, RN, CNE, CHCP

Associate Director, Accreditation and Compliance, Medscape, LLC

Disclosures

Leigh Schmidt, MSN, RN, CNE, CHCP, has no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has no relevant financial relationships.

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For Physicians

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Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

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From Medscape Education Neurology & Neurosurgery

CME / ABIM MOC

Test Your Expertise in the Diagnosis and Management of Rare Pediatric Epilepsies

Authors: Elaine C. Wirrell, MDFaculty and Disclosures

CME / ABIM MOC Released: 3/16/2023

Valid for credit through: 3/16/2024

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References

Symonds JD, et al. Early childhood epilepsies: epidemiology, classification, aetiology, and socio-economic determinants. Brain. 2021;144:2879-2891.
Berg AT, et al. Early-life epilepsies and the emerging role of genetic testing. JAMA Pediatr. 2017;171:863-871.
Dravet C. The core Dravet syndrome phenotype. Epilepsia. 2011;52:3-9.
Zuberi SM, et al. ILAE classification and definition of epilepsy syndromes with onset in neonates and infants: position statement by the ILAE Task Force on Nosology and Definitions. Epilepsia. 2022;63:1349-1397.
Hattori J, et al. A screening test for the prediction of Dravet syndrome before one year of age. Epilepsia. 2008;49:626-633.
Raga S, et al. Developmental and epileptic encephalopathies: recognition and approaches to care. Epileptic Disord. 2021;23:40-52.
Hebbar M, et al. Recent advances in epilepsy genomics and genetic testing. F1000Res. 2020;9:F1000 Faculty Rev - 185.
Wheless JW, et al. Dravet syndrome: a review of current management. Pediatr Neurol. 2020;107:28-40.
Silvennoinen K, et al. Late diagnoses of Dravet syndrome: how many individuals are we missing? Epilepsia Open. 2021;6:770-776.
Brunklaus A, et al. The gain of function SCN1A disorder spectrum: novel epilepsy phenotypes and therapeutic implications. Brain. 2022;145:3816-3831.
Scheffer IE. Solving the molecular basis of the developmental and epileptic encephalopathies: are we there yet? Epilepsy Curr. 2021;21:430-432.
Specchio N, et al. International League Against Epilepsy classification and definition of epilepsy syndromes with onset in childhood: position paper by the ILAE Task Force on Nosology and Definitions. Epilepsia. 2022;63:198-1442.
Brunklaus A, et al. Development and validation of a prediction model for early diagnosis of SCN1A-related epilepsies. Neurology. 2022;98:e1163-e1174.
The Broad Institute. The SCN1A-Epilepsy Prediction Model. 2022. Accessed February 16, 2023. http://scn1a-prediction-model.broadinstitute.org/
Li W, et al. Defining Dravet syndrome: an essential pre‐requisite for precision medicine trials. Epilepsia. 2021;69:2205-2217.
Wirrell EC, et al. International consensus on diagnosis and management of Dravet syndrome. Epilepsia. 2022;63:1761-1777.
Lagae L, et al. Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial. Lancet. 2019;394:2243-2254.
Nabbout R, et al. Fenfluramine for treatment-resistant seizures in patients with Dravet syndrome receiving stiripentol-inclusive regimens: a randomized clinical trial. JAMA Neurol. 2020;77:300-308.
Devinsky O, et al. Effect of cannabidiol on drop seizures in the Lennox-Gastaut syndrome. N Engl J Med. 2018;378:1888-1897.
Chiron C, et al. Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedicated trial. STICLO study group. Lancet. 2000;356:1638-1642.
Boyce DM, et al. Barriers to transition from pediatric to adult care for patients with Dravet syndrome: a focus group study of caregivers. 2020;109:107096.
Cross JH, et al. Expert opinion on the management of Lennox-Gastaut syndrome: treatment algorithms and practical considerations. Front Neurol. 2017;8:505.
Strzelczyk A, et al. Expanding the treatment landscape for Lennox-Gastaut syndrome: current and future strategies. CNS Drugs. 2021;35:61-83.
Cannabidiol [prescribing information]. Initial US approval 2018. Revised April 2020. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/210365s005s006s007lbl.pdf
Motte J, et al. Lamotrigine for generalized seizures associated with the Lennox-Gastaut syndrome. N Engl J Med. 1997;337:1807-1812.
Sachedo RC, et al. A double-blind, randomized trial of topiramate in Lennox-Gastaut syndrome. Neurology. 1999;52:1882-1887.
Conry JA, et al. Clobazam in the treatment of Lennox‐Gastaut syndrome. Epilepsia. 2009;50:1158-1166.
Conry JA, et al. Stable dosages of clobazam for Lennox-Gastaut syndrome are associated with sustained drop-seizure and total-seizure improvements over 3 years. Epilepsia. 2014;55:558-567.
Glauser T, et al. Rufinamide for generalized seizures associated with Lennox-Gastaut syndrome. Neurology. 2008;70:1950-1958.
Dodson WE. Felbamate in the treatment of Lennox‐Gastaut syndrome: results of a 12‐month open‐label study following a randomized clinical trial. Epilepsia. 1993;34:S18-S24.
Knupp KG, et al. Efficacy and safety of fenfluramine for the treatment of seizures associated with Lennox-Gastaut syndrome: a randomized clinical trial. JAMA Neurol. 2022;79:554-564.
Novak GP, et al. Carisbamate (RWJ-333369). Neurotherapeutics. 2007;4:106-109.
Mula M. Recent and future antiepileptic drugs and their impact on cognition: what can we expect? Expert Rev Neurother. 2012;12:667-671.
Knight EMP, et al. Safety and efficacy of ganaxolone in patients with CDKL5 deficiency disorder: results from the double-blind phase of a randomised, placebo-controlled, phase 3 trial. Lancet Neurol. 2022;21:417-427.
ClinicalTrials.gov. Open-label, long-term safety study of LP352 in subjects with developmental and epileptic encephalopathy. Accessed February 16, 2023. https://www.clinicaltrials.gov/ct2/show/NCT05626634

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CME / ABIM MOC Information

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Faculty and Disclosures

Faculty

Elaine C. Wirrell, MD

Editors

Frances McFarland, PhD, MA

Megan Breuer, PhD

Compliance Reviewer

Leigh Schmidt, MSN, RN, CNE, CHCP

Peer Reviewer

CME / ABIM MOC

Test Your Expertise in the Diagnosis and Management of Rare Pediatric Epilepsies

Credits Available

You Are Eligible For

Target Audience and Goal Statement

Disclosures

Faculty

Elaine C. Wirrell, MD

Editors

Frances McFarland, PhD, MA

Megan Breuer, PhD

Compliance Reviewer

Leigh Schmidt, MSN, RN, CNE, CHCP

Peer Reviewer

Accreditation Statements

For Physicians

Instructions for Participation and Credit

Test Your Expertise in the Diagnosis and Management of Rare Pediatric Epilepsies

References

PDF Downloads