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Case in Point: An Expert's Approach to Caring for Patients With Glioblastoma

  • Authors: David Reardon, MD
  • CME / ABIM MOC Released: 2/22/2023
  • Valid for credit through: 2/22/2024
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  • Credits Available

    Physicians - maximum of 0.25 AMA PRA Category 1 Credit(s)™

    ABIM Diplomates - maximum of 0.25 ABIM MOC points

    You Are Eligible For

    • Letter of Completion
    • ABIM MOC points

Target Audience and Goal Statement

This activity is intended for oncologists, including radiation oncologists, neurologists, surgeons, and other clinicians involved in the care of patients with glioblastoma (GBM).

The goal of this activity is for learners to be better able to care for patients with GBM.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Available treatment options for first-line management of GBM
  • Have greater competence related to
    • Personalizing care for patients with GBM
  • Demonstrate greater confidence in their ability to
    • Communicate treatment considerations with patients receiving therapy for GBM


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All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated. Others involved in the planning of this activity have no relevant financial relationships.


  • David Reardon, MD

    Professor of Medicine
    Harvard Medical School
    Clinical Director
    Center for Neuro-Oncology
    Dana-Farber Cancer Institute
    Boston, Massachusetts


    David Reardon, MD, has the following relevant financial relationships: 
    Consultant or advisor for: AbbVie Inc.; Advantagene; Agenus; Agios Pharmaceuticals; Amgen, Inc.; AnHeart Therapeutics; Avita Biomedical, Inc.; Bayer HealthCare; Boston Biomedical Associates; Boehringer Ingelheim Pharmaceuticals, Inc.; Bristol Myers Squibb Company; Celldex Therapeutics, Inc.; Dainippon Sumitono Pharma America; Deciphera Pharmaceuticals, Inc.; Del Mar Pharma; DNAtrix; Ellipses Pharma; EMD Serono, Inc.; F. Hoffman-LaRoche, Ltd; Genenta; Genentech/Roche; Imvax; Inovio; Janssen Research & Development, LLC; Johnson & Johnson; Kintara; Kiyatec; Medicenna Biopharma, Inc.; Merck & Co., Inc.; Merck KGaA; Monteris; Neuvogen; Novartis Pharmaceuticals; Novocure; Oncorus; OXiGENE, Inc.; Pyramid; Regeneron Pharmaceuticals, Inc.; Stemline; Taiho Oncology, Inc.; Vivacitas Oncology, Inc., Y-mabs Therapeutics
    Research funding from: Acerta Pharma; Agenus; Bristol Myers Squibb Company; Celldex Therapeutics, Inc.; EMD Serono, Inc.; Enterome; Epitopoietic Research Corporation; Incyte Corporation; Inovio; Insightec; Merck & Co., Inc.; Novartis Pharmaceuticals; Omniox; Tragara


  • Charlotte Warren

    Senior Director, Content Development, Medscape, LLC 


    Charlotte Warren, has no relevant financial relationships.

  • Hennah Patel, MPharm, RPh

    Medical Writer, Medscape, LLC 


    Hennah Patel has no relevant financial relationships.

Compliance Reviewer

  • Amanda Jett, PharmD, BCACP

    Associate Director, Accreditation and Compliance, Medscape, LLC


    Amanda Jett, PharmD, BCACP, has no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has no relevant financial relationships.

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In support of improving patient care, Medscape, LLC is jointly accredited with commendation by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.25 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

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This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 70% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read about the target audience, learning objectives, and author disclosures.
  2. Study the educational content online or print it out.
  3. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate, but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period, you can print out the tally as well as the certificates from the CME/CE Tracker.

*The credit that you receive is based on your user profile.


Case in Point: An Expert's Approach to Caring for Patients With Glioblastoma

Authors: David Reardon, MDFaculty and Disclosures

CME / ABIM MOC Released: 2/22/2023

Valid for credit through: 2/22/2024



  1. American Association of Neurological Surgeons. Glioblastoma multiforme. Updated 2023. Accessed February 8, 2023.
  2. Louis DN, et al. The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro Oncol. 2021;23:1231-1251.
  3. Kanderi T, et al. Glioblastoma multiforme. In: StatPearls. StatPearls Publishing; 2022. Updated September 12, 2022. Accessed February 16, 2023.
  4. Tamimi AF, et al. Epidemiology and outcome of glioblastoma. In: De Vleeschouwer S, ed. Glioblastoma. Codon Publications; 2017.
  5. Miller KD, et al. Brain and other central nervous system tumor statistics, 2021. CA Cancer J Clin. 2021;71:381-406.
  6. Hakan T, et al. Glioblastoma shortly after a normal conventional brain magnetic resonance imaging: a report of two cases and review of the literature. Asian J Neurosurg. 2021;16:433-436.
  7. Hanif F, et al. Glioblastoma multiforme: a review of its epidemiology and pathogenesis through clinical presentation and treatment. Asian Pac J Cancer Prev. 2017;18:3-9.
  8. Osborn AG, et al. The 2021 World Health Organization Classification of Tumors of the Central Nervous System: what neuroradiologists need to know. AJNR Am J Neuroradiol. 2022;43:928-937.
  9. Alzial G, et al. Wild-type isocitrate dehydrogenase under the spotlight in glioblastoma. Oncogene. 2022;41:613-621.
  10. Han S, et al. IDH mutation in glioma: molecular mechanisms and potential therapeutic targets. Br J Cancer. 2020;122:1580-1589.
  11. Stupp R, et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 2009;10:459-466.
  12. National Comprehensive Cancer Network (NCCN). Clinical practice guidelines in oncology. Central nervous system cancers (Version 2.2022). September 29, 2022.
  13. Nayak L, et al. Primary brain tumors in the elderly. Curr Neurol Neurosci Rep. 2010;10:252-258.
  14. Abedi AA, et al. A prognostic model for glioblastoma patients treated with standard therapy based on a prospective cohort of consecutive non-selected patients from a single institution. Front Oncol. 2021;11:597587.
  15. Carr MT, et al. Comorbid medical conditions as predictors of overall survival in glioblastoma patients. Sci Rep. 2019;9:20018.
  16. Liu J, et al. Prognostic and predictive factors in elderly patients with glioblastoma: a single-center retrospective study. Front Aging Neurosci. 2022;13:777962.
  17. Weller M, et al. EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood. Nat Rev Clin Oncol. 2021;18:170-186.
  18. Salama GR, et al. Diffusion weighted/tensor imaging, functional MRI and perfusion weighted imaging in glioblastoma-foundations and future. Front Neurol. 2018;8:660.
  19. Luna LP, et al. Can preoperative mapping with functional MRI reduce morbidity in brain tumor resection? A systematic review and meta-analysis of 68 observational studies. Radiology. 2021;300:338-349.
  20. Mohile NA, et al. Therapy for diffuse astrocytic and oligodendroglial tumors in adults: ASCO-SNO guideline. J Clin Oncol. 2022;40:403-426.
  21. Stupp R, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352:987-996.
  22. Garcia CR, et al. Hematological adverse events in the management of glioblastoma. J Neurooncol. 2022;156:153-161.
  23. Temozolomide [prescribing information]. Approved 1999. Revised September 2015.
  24. Perry JR, et al. Short-course radiation plus temozolomide in elderly patients with glioblastoma. N Engl J Med. 2017;376:1027-1037.
  25. Roa W, et al. Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: a prospective randomized clinical trial. J Clin Oncol. 2004;22:1583-1588.
  26. Wick W, et al. Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial. Lancet Oncol. 2012;13:707-715.
  27. Stupp R, et al. Effect of tumor-treating fields plus maintenance temozolomide vs maintenance temozolomide alone on survival in patients with glioblastoma: a randomized clinical trial. JAMA. 2017;318:2306-2316.
  28. Lacouture ME, et al. Prevention and management of dermatologic adverse events associated with tumor treating fields in patients with glioblastoma. Front Oncol. 2020;10:1045.
  29. Lou E, et al. Phase II trial of upfront bevacizumab and temozolomide for unresectable or multifocal glioblastoma. Cancer Med. 2013;2:185-195.
  30. Bagley SJ, et al. Glioblastoma clinical trials: current landscape and opportunities for improvement. Clin Cancer Res. 2022;28:594-602.
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