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Shifting Paradigms in Rare Bone Disorders: What Do New Treatments Mean for Outcomes?

  • Authors: Aliya Khan, MD, FRCPC, FACP, FACE; Richard Keen, PhD, FRCP
  • CME / ABIM MOC Released: 2/14/2023
  • Valid for credit through: 2/14/2024
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  • Credits Available

    Physicians - maximum of 0.25 AMA PRA Category 1 Credit(s)™

    ABIM Diplomates - maximum of 0.25 ABIM MOC points

    You Are Eligible For

    • Letter of Completion
    • ABIM MOC points

Target Audience and Goal Statement

This activity is intended for pediatricians, orthopedists and orthopedic surgeons, hematology/oncology specialists, diabetologists and endocrinologists, and medical geneticists.

The goal of this activity is for learners to be better able to increase awareness of how care pathways for rare bone disorders may change with the advent of new therapies.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Impact of new therapies for rare bone disorders on patient outcomes
    • Clinical data for emerging therapy in fibrodysplasia ossificans progressiva (FOP)


Medscape, LLC requires every individual in a position to control educational content to disclose all financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated. Others involved in the planning of this activity have no relevant financial relationships.

Disclosures for additional planners can be found here.


  • Aliya Khan, MD, FRCPC, FACP, FACE

    Clinical Professor of Medicine
    Division of Endocrinology and Metabolism, and Division of Geriatric Medicine
    Director of the Calcium Disorders Clinic
    Director of the Fellowship program in Metabolic Bone Disease
    McMaster University
    Hamilton, Ontario, Canada


    Aliya Khan, MD, FRCPC, FACP, FACE, has the following relevant financial relationships:
    Consultant or advisor for: Alexion Pharmaceuticals, Inc.; Amgen, Inc.; Ascendis Pharma; Takeda
    Speaker or member of speakers bureau for: Amgen, Inc.; Ultragenyx
    Research funding from: Amgen, Inc.; Ascendis Pharma; Chugai Pharma USA, LLC; Radius Health, Inc.; Takeda; Ultragenyx

  • Richard Keen, PhD, FRCP

    Consultant in Metabolic Bone Diseases
    Director of the Metabolic Bone Disease Centre
    Royal National Orthopedic Hospital NHS Trust
    London, United Kingdom


    Richard Keen, PhD, FRCP, has the following relevant financial relationships:
    Consultant or advisor for: Ipsen; Regeneron Pharmaceuticals, Inc.
    Speaker or member of speakers bureau for: Ipsen
    Research funding from: Incyte Corporation; Ipsen; Regeneron Pharmaceuticals, Inc.


  • Grace O’Malley, BSc, PhD

    Associate Medical Education Director, WebMD Global, LLC


    Grace O’Malley, BSc, PhD, has no relevant financial relationships.

Compliance Reviewer

  • Amanda Jett, PharmD, BCACP

    Associate Director, Accreditation and Compliance, Medscape, LLC


    Amanda Jett, PharmD, BCACP, has no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has no relevant financial relationships.

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    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.25 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

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This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 75% on the post-test.

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Shifting Paradigms in Rare Bone Disorders: What Do New Treatments Mean for Outcomes?

Authors: Aliya Khan, MD, FRCPC, FACP, FACE; Richard Keen, PhD, FRCPFaculty and Disclosures

CME / ABIM MOC Released: 2/14/2023

Valid for credit through: 2/14/2024


A Powerpoint version of the slides from this presentation
is available for use as a professional resource from Medscape Education.

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