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Clinical Case Challenge: Can You Effectively Manage Patients With NF1-Associated Tumors?

  • Authors: Roger J. Packer, MD; Jaishri Blakeley, MD; Cynthia J. Campen, MD, MScE
  • CME / ABIM MOC Released: 12/19/2022
  • Valid for credit through: 12/19/2023, 11:59 PM EST
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  • Credits Available

    Physicians - maximum of 1.00 AMA PRA Category 1 Credit(s)™

    ABIM Diplomates - maximum of 1.00 ABIM MOC points

    You Are Eligible For

    • Letter of Completion
    • ABIM MOC points

Target Audience and Goal Statement

This activity is intended for oncologists (including pediatric oncologists), neurologists, pediatricians, surgeons, and other healthcare providers involved in the care of patients with NF1.

The goal of this activity is for learners to be better able to manage patients with NF1-associated tumors as part of the multidisciplinary team.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Clinical manifestations of NF1-associated tumors
    • Clinical trial data evaluating the use of mitogen-activated protein kinase kinase (MEK) inhibitors for the treatment of NF1-associated tumors 
  • Have greater competence related to
    • Selecting appropriate, evidence-based therapy for patients with NF1-associated tumors
    • Mitigating potential adverse events associated with therapies for NF1-associated tumors
  • Demonstrate greater confidence in their ability to
    • Effectively coordinate transitions of care with members of the multidisciplinary team


Medscape, LLC requires every individual in a position to control educational content to disclose all financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated. Others involved in the planning of this activity have no relevant financial relationships.


  • Roger J. Packer, MD

    Senior VP of Neuroscience and Behavior Medicine
    Director, Gilbert Family NF1 Institute
    Director, Brain Tumor Institute
    Children's National Hospital
    Washington, DC


    Roger J. Packer, MD,  has the following relevant financial relationships:
    Consultant or advisor for: Novartis; YM Pharmaceuticals
    Speaker or member of speakers bureau for: AstraZeneca
    Research funding from: Sonalesence

  • Jaishri Blakeley, MD

    Professor of Neurology, Neurosurgery, and Oncology
    The Marjorie Bloomberg Tiven Professor of Neurofibromatosis
    Johns Hopkins University School of Medicine
    Director, Neurofibromatosis Therapeutic Acceleration Program
    Director, Johns Hopkins Comprehensive Neurofibromatosis Program
    Baltimore, Maryland


    Participation by Dr Blakeley does not constitute or imply endorsement by the Johns Hopkins University or the Johns Hopkins Hospital and Health System.
    Jaishri Blakeley, MD, has the following relevant financial relationships:
    Consultant or advisor for: Springworks Therapeutics; TriAct Pharmaceuticals
    Research funding from: Bristol Myers Squibb

  • Cynthia J. Campen, MD, MScE

    Clinical Associate Professor, Neurology & Neurological Sciences
    Clinical Associate Professor, Pediatrics Clinical Associate
    Co-Director, Children’s NF program
    Professor, Neurosurgery (courtesy)
    Stanford University
    Stanford, California


    Cynthia Campen, MD, MSCE has the following relevant financial relationships:
    Consultant or advisor for: Alexion (former)


  • John Churchwell, PhD

    Medical Education Director, Medscape, LLC


    John Churchwell, PhD, has the following relevant financial relationships:  
    Formerly employed by an ineligible company: Medtronic (ended 2021) 

Compliance Reviewer

  • Leigh Schmidt, MSN, RN, CNE, CHCP

    Associate Director, Accreditation and Compliance, Medscape, LLC


    Leigh Schmidt, MSN, RN, CNE, CHCP, has no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has no relevant financial relationships.

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In support of improving patient care, Medscape, LLC is jointly accredited with commendation by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

    Contact This Provider

For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]

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There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 70% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read about the target audience, learning objectives, and author disclosures.
  2. Study the educational content online or print it out.
  3. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate, but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period, you can print out the tally as well as the certificates from the CME/CE Tracker.

*The credit that you receive is based on your user profile.


Clinical Case Challenge: Can You Effectively Manage Patients With NF1-Associated Tumors?

Authors: Roger J. Packer, MD; Jaishri Blakeley, MD; Cynthia J. Campen, MD, MScEFaculty and Disclosures

CME / ABIM MOC Released: 12/19/2022

Valid for credit through: 12/19/2023, 11:59 PM EST


A Powerpoint version of the slides from this presentation
is available for use as a professional resource from Medscape Education.

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