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All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated. Others involved in the planning of this activity have no relevant financial relationships.

Moderator

Martin S. Maron, MD

Director of the Hypertrophic Cardiomyopathy Center
Lahey Hospital & Medical Center
Burlington, Massachusetts

Disclosures

Martin S. Maron, MD, has the following relevant financial relationships:
Consultant or advisor for: Cytokinetics; Imbria
Speaker or member of speakers bureau for: iRhythm
Research funding from: iRhythm
Contracted researcher for: Cytokinetics; Imbria; iRhythm
Other: Steering Committee for Cytokinetics

Faculty

Ahmad Masri, MD, MS

Assistant Professor of Medicine
Oregon Health & Science University
Director, Hypertrophic Cardiomyopathy Center
Director, Cardiac Amyloidosis Program
Portland, Oregon

Disclosures

Ahmad Masri, MD, MS, has the following relevant financial relationships:
Consultant or advisor for: Attralus; BridgeBio Pharma; Bristol Myers Squibb; Cytokinetics; Ionis; Tenaya Therapeutics
Research funding from: Akcea; Ionis; Pfizer, Inc.; Ultromics

Carolyn Ho, MD

Associate Professor
Harvard Medical School
Cardiovascular Medicine
Brigham and Women's Hospital
Medical Director of the Cardiovascular Genetics Center
Boston, Massachusetts

Disclosures

Carolyn Ho, MD, has the following relevant financial relationships:
Consultant or advisor for: Biomarin/DiNAQOR; Bristol Myers Squibb; Cytokinetics
Research funding from: Bristol Myers Squibb; Pfizer, Inc.

Christopher M. Kramer, MD

Distinguished Professor of Cardiovascular Medicine
George A. Beller MD/Lantheus Medical Imaging
Charlottesville, Virginia

Disclosures

Christopher M. Kramer, MD, has the following relevant financial relationships:
Consultant or advisor for: Bristol Myers Squibb; Cytokinetics; Lilly; Xencor
Research funding from: Bristol Myers Squibb; Cytokinetics; Lilly

Editor

Joy P. Marko, MS, APN-C, CCMEP

Senior Medical Education Director, Medscape, LLC

Disclosures

Joy P. Marko, MS, APN-C, CCMEP, has no relevant financial relationships.

Compliance Reviewer

Leigh Schmidt, MSN, RN, CMSRN, CNE, CHCP

Associate Director, Accreditation and Compliance, Medscape, LLC

Disclosures

Leigh Schmidt, MSN, RN, CMSRN, CNE, CHCP, has no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has no relevant financial relationships.

CME / ABIM MOC

Transforming the Treatment of Hypertrophic Cardiomyopathy: Key Updates on Sarcomere-Directed Therapies

Authors: Martin S. Maron, MD; Ahmad Masri, MD, MS; Carolyn Ho, MD; Christopher M. Kramer, MD
CME / ABIM MOC Released: 11/28/2022
Valid for credit through: 11/28/2023

Start Activity

Credits Available

Physicians - maximum of 1.00 AMA PRA Category 1 Credit(s)™

ABIM Diplomates - maximum of 1.00 ABIM MOC points

You Are Eligible For
- Letter of Completion
- ABIM MOC points

Target Audience and Goal Statement

This activity is intended for cardiologists, primary care physicians, and surgeons.

The goal of this activity is for learners to be better able to recognize the latest advances in the treatment of HCM, including new data for myosin inhibition therapy and implications for patient care.

Upon completion of this activity, participants will:

Have increased knowledge regarding the
- Role of new and emerging sarcomere-directed therapies in addressing the underlying pathophysiology of HCM
- Latest clinical trial data on the use of sarcomere-directed therapies to treat HCM
- Key differences between new and emerging sarcomere-directed therapies for the treatment of HCM
Have greater competence related to
- Clinical use of cardiac myosin inhibition therapy in patients with HCM

Disclosures

Moderator

Martin S. Maron, MD

Director of the Hypertrophic Cardiomyopathy Center
Lahey Hospital & Medical Center
Burlington, Massachusetts

Disclosures

Martin S. Maron, MD, has the following relevant financial relationships:
Consultant or advisor for: Cytokinetics; Imbria
Speaker or member of speakers bureau for: iRhythm
Research funding from: iRhythm
Contracted researcher for: Cytokinetics; Imbria; iRhythm
Other: Steering Committee for Cytokinetics

Faculty

Ahmad Masri, MD, MS

Assistant Professor of Medicine
Oregon Health & Science University
Director, Hypertrophic Cardiomyopathy Center
Director, Cardiac Amyloidosis Program
Portland, Oregon

Disclosures

Ahmad Masri, MD, MS, has the following relevant financial relationships:
Consultant or advisor for: Attralus; BridgeBio Pharma; Bristol Myers Squibb; Cytokinetics; Ionis; Tenaya Therapeutics
Research funding from: Akcea; Ionis; Pfizer, Inc.; Ultromics

Carolyn Ho, MD

Associate Professor
Harvard Medical School
Cardiovascular Medicine
Brigham and Women's Hospital
Medical Director of the Cardiovascular Genetics Center
Boston, Massachusetts

Disclosures

Carolyn Ho, MD, has the following relevant financial relationships:
Consultant or advisor for: Biomarin/DiNAQOR; Bristol Myers Squibb; Cytokinetics
Research funding from: Bristol Myers Squibb; Pfizer, Inc.

Christopher M. Kramer, MD

Distinguished Professor of Cardiovascular Medicine
George A. Beller MD/Lantheus Medical Imaging
Charlottesville, Virginia

Disclosures

Christopher M. Kramer, MD, has the following relevant financial relationships:
Consultant or advisor for: Bristol Myers Squibb; Cytokinetics; Lilly; Xencor
Research funding from: Bristol Myers Squibb; Cytokinetics; Lilly

Editor

Joy P. Marko, MS, APN-C, CCMEP

Senior Medical Education Director, Medscape, LLC

Disclosures

Joy P. Marko, MS, APN-C, CCMEP, has no relevant financial relationships.

Compliance Reviewer

Leigh Schmidt, MSN, RN, CMSRN, CNE, CHCP

Associate Director, Accreditation and Compliance, Medscape, LLC

Disclosures

Leigh Schmidt, MSN, RN, CMSRN, CNE, CHCP, has no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has no relevant financial relationships.

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For Physicians

Medscape, LLC designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

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For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]

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There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 70% on the post-test.

Follow these steps to earn CME/CE credit*:

Read about the target audience, learning objectives, and author disclosures.
Study the educational content online or print it out.
Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate, but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period, you can print out the tally as well as the certificates from the CME/CE Tracker.

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From Medscape Education Cardiology

CME / ABIM MOC

Transforming the Treatment of Hypertrophic Cardiomyopathy: Key Updates on Sarcomere-Directed Therapies

Authors: Martin S. Maron, MD; Ahmad Masri, MD, MS; Carolyn Ho, MD; Christopher M. Kramer, MDFaculty and Disclosures

CME / ABIM MOC Released: 11/28/2022

Valid for credit through: 11/28/2023

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Disclaimer

The educational activity presented above may involve simulated, case-based scenarios. The patients depicted in these scenarios are fictitious and no association with any actual patient, whether living or deceased, is intended or should be inferred.

The material presented here does not necessarily reflect the views of Medscape, LLC, or any individuals or commercial entities that support companies that support educational programming on medscape.org. These materials may include discussion of therapeutic products that have not been approved by the US Food and Drug Administration, off-label uses of approved products, or data that were presented in abstract form. These data should be considered preliminary until published in a peer-reviewed journal. Readers should verify all information and data before treating patients or employing any therapies described in this or any educational activity. A qualified healthcare professional should be consulted before using any therapeutic product discussed herein.

Faculty and Disclosures

Moderator

Martin S. Maron, MD

Faculty

Ahmad Masri, MD, MS

Carolyn Ho, MD

Christopher M. Kramer, MD

Editor

Joy P. Marko, MS, APN-C, CCMEP

Compliance Reviewer

Leigh Schmidt, MSN, RN, CMSRN, CNE, CHCP

Peer Reviewer

CME / ABIM MOC

Transforming the Treatment of Hypertrophic Cardiomyopathy: Key Updates on Sarcomere-Directed Therapies

Credits Available

You Are Eligible For

Target Audience and Goal Statement

Disclosures

Moderator

Martin S. Maron, MD

Faculty

Ahmad Masri, MD, MS

Carolyn Ho, MD

Christopher M. Kramer, MD

Editor

Joy P. Marko, MS, APN-C, CCMEP

Compliance Reviewer

Leigh Schmidt, MSN, RN, CMSRN, CNE, CHCP

Peer Reviewer

Accreditation Statements

For Physicians

Instructions for Participation and Credit

Transforming the Treatment of Hypertrophic Cardiomyopathy: Key Updates on Sarcomere-Directed Therapies

Learning Feedback Questions