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Prosthetic Joint Infection Diagnostics: Exploring the Role of Syndromic Testing in Practice

  • Authors: Javad Parvizi, MD, FRCS; Nicolás Cortés-Penfield, MD; Colin A. Mudrick, MD
  • CME / ABIM MOC Released: 11/17/2022
  • Valid for credit through: 11/17/2023
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  • Credits Available

    Physicians - maximum of 0.75 AMA PRA Category 1 Credit(s)™

    ABIM Diplomates - maximum of 0.75 ABIM MOC points

    You Are Eligible For

    • Letter of Completion
    • ABIM MOC points

Target Audience and Goal Statement

This activity is intended for orthopedists, orthopedic surgeons, and infectious disease specialists.

The goal of this activity is for learners to be better able to diagnose PJIs and to differentiate them from other joint conditions to allow timely initiation of appropriate management.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding
    • Key aspects of diagnostic methodologies for PJIs
    • How syndromic testing for PJIs can improve antimicrobial stewardship efforts
  • Have greater competence related to
    • Using rapid diagnostic technologies to diagnose PJIs


Medscape, LLC requires every individual in a position to control educational content to disclose all financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated. Others involved in the planning of this activity have no relevant financial relationships.

Disclosures for additional planners can be found here.


  • Javad Parvizi, MD, FRCS

    James Edwards Professor of Orthopedic Surgery
    Sidney Kimmel Medical College
    Rothman Institute
    Thomas Jefferson University Hospital
    Philadelphia, Pennsylvania



    Javad Parvizi, Javad Parvizi, has the following relevant financial relationships:
    Consultant or advisor for: Becton Dickenson; Cardinal Health; Corentec; Ethicon; KCI/3M (Acelity); MicroGenDx; Peptilogics; Tenor; Zimmer Biomet
    Research funding from: 3M; Aesculap; AO Spine; Biomet; Cempra; Ceramtec; Department of Defense; DePuy; Integra; Lima; Myoscience; NDRI; NIH; Novartis; Pfizer; Rotation Medical; Simplify Medical; Smith & Nephew; OREF; Stelkast; Stryker Orthopedics; Synthes; TissueGene; Tornier; Orthospace; Zimmer Biomet
    Royalties from: Becton Dickenson; Corentec
    Stock options from: Alphaeon/Strathsby Crown; Ceribell; Acumed; Elute; Hip Innovation Technologies; Illuminus; Intellijoint; Molecular Surface Technologies; Nanooxygenic; Osteal; Parvizi Surgical Innovations and Subsidiaries; Peptilogic; PRN-Veterinary; Sonata 


  • Nicolás Cortés-Penfield, MD

    Assistant Professor
    Division of Infectious Diseases
    Medical Director
    Outpatient Parenteral Antimicrobial Therapy Program
    University of Nebraska Medical Center
    Omaha, Nebraska



    Nicolás Cortés-Penfield, MD, has the following relevant financial relationships:
    Research funding from: Allergan Pharmaceuticals 

  • Colin A. Mudrick, MD

    Orthopedic Surgeon
    Tuckahoe Orthopedic Associates
    Richmond, Virginia



    Colin A. Mudrick, MD, has the following relevant financial relationships:
    Consultant or advisor for: Depuy/Synthes (Johnson and Johnson)


  • Roderick Smith, MS

    Senior Medical Education Director, Medscape, LLC


    Roderick Smith, MS, has no relevant financial relationships.

Compliance Reviewer

  • Leigh Schmidt, MSN, RN, CNE, CHCP

    Associate Director, Accreditation and Compliance, Medscape, LLC


    Leigh Schmidt, MSN, RN, CNE, CHCP, has no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has no relevant financial relationships.

Accreditation Statements

In support of improving patient care, Medscape, LLC is jointly accredited with commendation by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.75 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

    Contact This Provider

For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]

Instructions for Participation and Credit

There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 75% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read the target audience, learning objectives, and author disclosures.
  2. Study the educational content online or printed out.
  3. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period you can print out the tally as well as the certificates from the CME/CE Tracker.

*The credit that you receive is based on your user profile.


Prosthetic Joint Infection Diagnostics: Exploring the Role of Syndromic Testing in Practice

Authors: Javad Parvizi, MD, FRCS; Nicolás Cortés-Penfield, MD; Colin A. Mudrick, MDFaculty and Disclosures

CME / ABIM MOC Released: 11/17/2022

Valid for credit through: 11/17/2023


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