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Monoclonal Antibody Therapies for SARS-CoV2: Are You Up to Date?

  • Authors: Myron S. Cohen, MD; Odile Launay, MD, PhD; Raymund R. Razonable, MD; Davey Smith, MD, MAS
  • CME Released: 11/11/2022
  • Valid for credit through: 11/11/2023
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  • Credits Available

    Physicians - maximum of 0.50 AMA PRA Category 1 Credit(s)™

    You Are Eligible For

    • Letter of Completion

Target Audience and Goal Statement

This activity is intended for primary care physicians, infectious disease/HIV specialists, allergists and clinical immunologists, pulmonologists, hematology/oncology specialists, nephrologists, and transplant surgeons.

The goal of this activity is that learners will be better able to understand the role of vaccines vs mAb therapies for both treatment and pre-exposure prophylaxis for COVID-19, and be brought up to date on the current mAbs and key clinical data.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • mAb therapeutics for SARS-CoV-2
    • Clinical data for mAbs for SARS-CoV-2
  • Have greater competence related to
    • Identifying patients who might benefit from pre-exposure prophylaxis


Medscape, LLC requires every individual in a position to control educational content to disclose all financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated. Others involved in the planning of this activity have no relevant financial relationships.

Disclosures for additional planners can be found here.


  • Myron S. Cohen, MD

    Yeargan-Bate Professor of Medicine, Microbiology and Epidemiology
    Associate Vice Chancellor for Medical Affairs and Global Health
    Director, Institute for Global Health and Infectious Diseases
    University Of North Carolina at Chapel Hill
    Chapel Hill, North Carolina, United States


    Myron S. Cohen, MD, has the following relevant financial relationships:
    Consultant or advisor for: Aerium; AstraZeneca; Atea; GlaxoSmithKline
    Stock options from: Aerium

  • Davey Smith, MD, MAS

    Professor of Medicine
    Head, Infectious Diseases and Global Public Health
    University of California, San Diego
    San Diego, California, United States


    Davey Smith, MD, MAS, has the following relevant financial relationships:
    Consultant or advisor for: Bayer Healthcare; Kiadis; Matrix Biomed
    Stock options from: Fluxergy

  • Odile Launay, MD, PhD

    Professor of Infectious and Tropical Diseases
    Université Paris Cité
    Paris, France


    Odile Launay, MD, PhD, has the following relevant financial relationships:
    Consultant or advisor for: Abivax; AstraZeneca; Biomerieux; GlaxoSmithKline; Merck Sharp & Dohme; Novartis; Sanofi
    Research funding from: AstraZeneca; Biomerieux; GlaxoSmithKline; Merck Sharp & Dohme; Sanofi

  • Raymund R. Razonable, MD

    Professor of Medicine
    Mayo Clinic College of Medicine
    Vice Chair
    Division of Public Health, Infectious Diseases and Occupational Medicine
    Mayo Clinic
    Rochester, Minnesota, United States


    Raymund R. Razonable, MD, has the following relevant financial relationships:
    Consultant or advisor for: ExeVir
    Research funding from: Gilead Sciences; Regeneron; Roche


  • Shanthi Voorn, PhD

    Medical Education Director, WebMD Global, LLC


    Shanthi Voorn, PhD, has no relevant financial relationships.

  • Diana Lucifero, PhD

    Scientific Content Manager, WebMD Global, LLC


    Diana Lucifero, PhD, has no relevant financial relationships.

Compliance Reviewer

  • Leigh Schmidt, MSN, RN, CNE, CHCP

    Associate Director, Accreditation and Compliance, Medscape, LLC


    Leigh Schmidt, MSN, RN, CNE, CHCP, has no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has no relevant financial relationships.

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In support of improving patient care, Medscape, LLC is jointly accredited with commendation by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

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This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 75% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read the target audience, learning objectives, and author disclosures.
  2. Study the educational content online or printed out.
  3. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

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Monoclonal Antibody Therapies for SARS-CoV2: Are You Up to Date?

Authors: Myron S. Cohen, MD; Odile Launay, MD, PhD; Raymund R. Razonable, MD; Davey Smith, MD, MASFaculty and Disclosures

CME Released: 11/11/2022

Valid for credit through: 11/11/2023


Note: The information on the coronavirus outbreak is continually evolving. The content within this activity serves as a historical reference to the information that was available at the time of this publication. We continue to add to the collection of activities on this subject as new information becomes available. It is the policy of Medscape Education to avoid the mention of brand names or specific manufacturers in accredited educational activities. However, manufacturer names related to the approved COVID-19 vaccines are provided in this activity in an effort to promote clarity. The use of manufacturer names should not be viewed as an endorsement by Medscape of any specific product or manufacturer.   

Update: When this program was recorded, the FDA had granted several monoclonal antibodies with emergency use authorization. However, due to the high frequency of variants, the US FDA has revoked the emergency use authorization (EUA) of monoclonal antibodies against SARS-CoV-2 for pre-exposure prophylaxis and treatment of COVID-19. Please refer to your national and local guidelines for further updates.

Contents of This CME Activity

All sections of this activity are required for credit.

Which Patients Can Benefit From Monoclonal Antibody Therapy?

Do you know who among your patients would benefit most from mAb treatment or prophylaxis?
Myron S. Cohen, MD

How Do Monoclonal Antibodies Work?

Learn about the key differences between antibody therapies and vaccines.
Davey Smith, MD, MAS

Summary of Key Clinical Data From Monoclonal Antibodies: Treatment and PrEP

Are you up-to-date with the latest clinical data on mAbs that are effective for COVID-19 treatment and prophylaxis?
Odile Launay, MD, PhD

Addressing Key Questions on the Use of Monoclonal Antibodies

Dr Razonable concludes with practical insights on overcoming challenges in mAb use.
Raymund R. Razonable, MD
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