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Rett Syndrome Journal Club: A Review of Recent Advancements in Care

  • Authors: Jeffrey Neul, MD, PhD; Eric Marsh, MD, PhD; Alan K. Percy, MD
  • CME / ABIM MOC Released: 11/7/2022
  • Valid for credit through: 11/7/2023, 11:59 PM EST
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  • Credits Available

    Physicians - maximum of 0.50 AMA PRA Category 1 Credit(s)™

    ABIM Diplomates - maximum of 0.50 ABIM MOC points

    You Are Eligible For

    • Letter of Completion
    • ABIM MOC points

Target Audience and Goal Statement

This activity is intended for neurologists, pediatricians and primary care physicians.

The goal of this activity is for learners to be better able to increase their awareness of new data for the identification and management of Rett syndrome from data presented at medical conferences and publications.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Recent data pertaining to the timely recognition of Rett syndrome
    • Investigational therapies studied for the management of Rett syndrome


Medscape, LLC requires every individual in a position to control educational content to disclose all financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated. Others involved in the planning of this activity have no relevant financial relationships.


  • Jeffrey Neul, MD, PhD

    Professor of Pediatrics
    Division of Neurology, Pharmacology, and Special Education
    Annette Schaffer Eskind Chair and Director
    Vanderbilt Kennedy Center
    Vanderbilt University Medical Center
    Nashville, Tennessee


    Jeffrey Neul, MD, PhD, has no relevant financial relationships.


  • Eric Marsh, MD, PhD

    Associate Professor of Neurology and Pediatrics
    Clinical Director, Orphan Disease Center
    Children’s Hospital of Philadelphia
    Philadelphia, Pennsylvania


    Eric Marsh, MD, PhD, has the following relevant financial relationships:
    Consultant or advisor for: Acadia Pharmaceuticals; Stoke Therapeutics (former)
    Research funding from: Curaleaf Inc.
    Contracted researcher for: Acadia Pharmaceuticals; Epigenyx Pharmaceuticals; Marinus Pharmaceuticals; Stoke Therapeutics; Takeda Pharmaceuticals; Zogenix Pharmaceuticals

  • Alan K. Percy, MD

    Professor of Pediatrics, Neurology, Neurobiology, Genetics, and Psychology-Emeritus
    Sarah Katherine Bateh Endowed Professorship for Rett Syndrome-Emeritus
    University of Alabama at Birmingham
    Birmingham, Alabama


    Alan K. Percy, MD, has the following relevant financial relationships:
    Consultant or advisor for: Acadia Pharmaceuticals; Neuogene
    Contracted researcher for: Acadia Pharmaceuticals; Anavex


  • Pakinam Aboulsaoud, PharmD

    Medical Education Director, Medscape, LLC


    Pakinam Aboulsaoud, PharmD, has no relevant financial relationships.

  • Yoji Yamaguchi, MA, ELS

    Scientific Content Manager, Medscape, LLC


    Yoji Yamaguchi, MA, ELS, has no relevant financial relationships.

Compliance Reviewer

  • Amanda Jett, PharmD, BCACP

    Associate Director, Accreditation and Compliance, Medscape, LLC


    Amanda Jett, PharmD, BCACP, has no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has no relevant financial relationships.

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    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.50 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

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For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]

Instructions for Participation and Credit

There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 70% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read about the target audience, learning objectives, and author disclosures.
  2. Study the educational content online or print it out.
  3. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate, but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period, you can print out the tally as well as the certificates from the CME/CE Tracker.

*The credit that you receive is based on your user profile.


Rett Syndrome Journal Club: A Review of Recent Advancements in Care

Authors: Jeffrey Neul, MD, PhD; Eric Marsh, MD, PhD; Alan K. Percy, MDFaculty and Disclosures

CME / ABIM MOC Released: 11/7/2022

Valid for credit through: 11/7/2023, 11:59 PM EST


Since this program has been recorded, the FDA has approved trofinetide oral solution indicated for the treatment of Rett syndrome in adults and pediatric patients 2 years of age and older [Trofinetide [prescribing information] Approved 2023. Revised March 2023].

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