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Taking Steps Forward in Type 1 Diabetes Screening and Staging

  • Authors: Kimber Simmons, MD, MS; Kevan C. Herold, MD; Emily K. Sims, MD, MS
  • CME / ABIM MOC / CE Released: 10/18/2022
  • Valid for credit through: 10/18/2023, 11:59 PM EST
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Target Audience and Goal Statement

This activity is intended for pediatric endocrinologists, diabetologists/endocrinologists, pediatricians, nurses, nurse practitioners, physician assistants, and other healthcare providers who see/care for patients with T1D.

The goal of this activity is for learners to be better able to screen for and stage T1D.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Recommendations for screening and staging pediatric patients at risk for T1D 
    • Continued follow-up after diagnosis for patients with T1D
  • Have greater competence related to
    • Screening and staging pediatric patients at high risk for T1D


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All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated. Others involved in the planning of this activity have no relevant financial relationships.


  • Kimber Simmons, MD, MS

    Assistant Professor of Pediatrics
    Pediatric Endocrinologist
    Barbara Davis Center for Diabetes
    University of Colorado School of Medicine
    Aurora, Colorado


    Kimber Simmons, MD, MS, has the following relevant financial relationships:
    Consultant or advisor for: Dexcom; Provention Bio, Inc.
    Speaker or member of speakers bureau for: Dexcom
    Research funding from: Novartis; Provention Bio, Inc.


  • Kevan C. Herold, MD

    C. N. H. Long Professor of Immunology
    Professor of Medicine (Endocrinology)
    Yale School of Medicine
    New Haven, Connecticut


    Kevan C. Herold, MD, has the following relevant financial relationships:
    Consultant or advisor for: Abata; Isoplexis; NexImmune; Tiziana Life Sciences
    Research funding from: NexImmune
    Contracted researcher for: Provention Bio, Inc.
    Other: Scientific Advisory Board NexImmune

  • Emily K. Sims, MD, MS

    Associate Professor of Pediatrics
    Pediatric Endocrinology and Diabetology
    Indiana University School of Medicine Center for Diabetes and Metabolic Diseases
    Assistant Director, Faculty Development and Translational Research
    Herman B Wells Center for Pediatric Research
    Associate Director 
    IU Medical Scientist Training Program 
    Indianapolis, Indiana 


    Emily K. Sims, MD, MS, has no relevant financial relationships.


  • Joy P. Marko, MS, APN-C, CCMEP

    Senior Medical Education Director, Medscape, LLC 


    Joy P. Marko, MS, APN-C, CCMEP, has no relevant financial relationships.  

  • Frederick Stange, DO

    Scientific Content Manager, Medscape, LLC 


    Frederick Stange, DO, has no relevant financial relationships.  

Compliance Reviewer/Nurse Planner

  • Lisa Simani, APRN, MS, ACNP

    Associate Director, Accreditation and Compliance, Medscape, LLC


    Lisa Simani, APRN, MS, ACNP, has no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has no relevant financial relationships.

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    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.75 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

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    For Nurses

  • Awarded 0.75 contact hour(s) of nursing continuing professional development for RNs and APNs; 0.25 contact hours are in the area of pharmacology.

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Taking Steps Forward in Type 1 Diabetes Screening and Staging

Authors: Kimber Simmons, MD, MS; Kevan C. Herold, MD; Emily K. Sims, MD, MSFaculty and Disclosures

CME / ABIM MOC / CE Released: 10/18/2022

Valid for credit through: 10/18/2023, 11:59 PM EST


Editor’s Note: On November 17, 2022, the US Food and Drug Administration (FDA) approved teplizumab-mzwv, a first-in class anti-CD3 monoclonal antibody, to delay the onset of stage 3 T1D in adults and pediatric patients over 8 years old at-risk of disease progression (ie, those who currently have stage 2 T1D). Common adverse reactions of teplizumab-mzwv include lymphopenia, rash, leukopenia, and headache.

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