You are leaving Medscape Education
Cancel Continue
Log in to save activities Your saved activities will show here so that you can easily access them whenever you're ready. Log in here CME & Education Log in to keep track of your credits.



Extraintestinal Pathogenic Escherichia coli (ExPEC): Test Your Knowledge!

  • Authors: Ferric C Fang, MD
  • CME / ABIM MOC Released: 8/17/2022
  • Valid for credit through: 8/17/2023
Start Activity

  • Credits Available

    Physicians - maximum of 0.25 AMA PRA Category 1 Credit(s)™

    ABIM Diplomates - maximum of 0.25 ABIM MOC points

    You Are Eligible For

    • Letter of Completion
    • ABIM MOC points

Target Audience and Goal Statement

This activity is intended for primary care and other physicians who may encounter patients at risk for or with ExPEC infections.

The goal of this activity is that learners will be better able to assess their knowledge of ExPEC infections.

Upon completion of this activity, participants will:

  • Have increased knowledge of
    • ExPEC infections
  • Self-assess learning needs related to
    • ExPEC infections


Medscape, LLC requires every individual in a position to control educational content to disclose all financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated. Others involved in the planning of this activity have no relevant financial relationships.


  • Ferric C Fang, MD

    Professor, Laboratory Medicine and Pathology, and Microbiology
    Adjunct Professor, Department of Medicine, Division of Allergy and Infectious Diseases
    Director, Harborview Medical Center Clinical Microbiology Laboratory
    University of Washington School of Medicine
    Seattle, Washington


    Ferric C. Fang, MD, has the following relevant financial relationships:
    Consultant or advisor for: BioFire Diagnostics


  • Maria B. Uravich, BSc, ELS

    Senior Medical Education Director, WebMD Global, LLC 


    Maria B. Uravich, BSc, ELS, has no relevant financial relationships.  

  • Megan Breuer, PhD

    Medical Writer, Medscape, LLC


    Megan Breuer, PhD, has the following relevant financial relationships: Consultant/advisor Paratek Pharmaceuticals, Inc. (former)  

  • Ashley Stumvoll, MRes

    Associate Medical Writer, Medscape, LLC


    Ashley Stumvoll, MRes, has no relevant financial relationships.

Compliance Reviewer

  • Susan L. Smith, MN, PhD

    Associate Director, Accreditation and Compliance, Medscape, LLC


    Susan L. Smith, MN, PhD, has no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has no relevant financial relationships.

Accreditation Statements

In support of improving patient care, Medscape, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.25 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

    Contact This Provider

For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]

Instructions for Participation and Credit

There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit(s)™, you must receive a minimum score of 75% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read about the target audience, learning objectives, and author disclosures.
  2. Study the educational content online or print it out.
  3. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate, but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period, you can print out the tally as well as the certificates from the CME/CE Tracker.

*The credit that you receive is based on your user profile.


Extraintestinal Pathogenic Escherichia coli (ExPEC): Test Your Knowledge!

Authors: Ferric C Fang, MDFaculty and Disclosures

CME / ABIM MOC Released: 8/17/2022

Valid for credit through: 8/17/2023



  1. Jang J, et al. Environmental Escherichia coli: ecology and public health implications—a review. J Appl Microbiol. 2017;123:570-581.
  2. Breijyeh Z, et al. Resistance of gram-negative bacteria to current antibacterial agents and approaches to resolve it. Molecules. 2020;25:1340.
  3. Geurtsen J, et al. Genomics and pathotypes of the many faces of Escherichia coli. FEMS Microbiol Rev. 2022. doi: 10.1093/femsre/fuac031. [Epub ahead of print]
  4. Longhi C, et al. Extraintestinal pathogenic Escherichia coli: beta-lactam antibiotic and heavy metal resistance. Antibiotics (Basel). 2022;11:328.
  5. Manges AR, et al. Global extraintestinal pathogenic Escherichia coli (ExPEC) lineages. Clin Microbiol Rev. 2019;32:e00135-18.
  6. Subashchandrabose S, et al. Virulence and fitness determinants of uropathogenic Escherichia coli. Microbiol Spectr. 2015;3. doi: 10.1128/microbiolspec.UTI-0015-2012.
  7. Phan M-D, et al. the serum resistome of a globally disseminated multidrug resistant uropathogenic Escherichia coli clone. PLoS Genet. 2013;9:e1003834.
  8. Bryan A, et al. Shiga toxin producing Escherichia coli. Clin Lab Med. 2015;35:247-272.
  9. Terlizzi ME, et al. UroPathogenic Escherichia coli (UPEC) infections: virulence factors, bladder responses, antibiotic, and non-antibiotic antimicrobial strategies. Front Microbiol. 2017;8:1566.
  10. Biran D, et al. Extraintestinal pathogenic Escherichia coli. Curr Top Microbiol Immunol. 2018;416:149-161.
  11. Jones RN. Microbial etiologies of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia. Clin Infect Dis. 2010;51:S81-S87.
  12. Singer RS. Urinary tract infections attributed to diverse ExPEC strains in food animals: evidence and data gaps. Front Microbiol. 2015;6:28.
  13. Torres E et al. Prevalence and transmission dynamics of Escherichia coli ST131 among contacts of infected community and hospitalized patients. Clin Microbiol Infect. 2018;24:618-623.
  14. Liu CM et al. Escherichia coli ST131-H22 as a foodborne uropathogen. mBio. 2018;9:e00470-18.
  15. Pitout JD. Extraintestinal pathogenic Escherichia coli: an update on antimicrobial resistance, laboratory diagnosis and treatment. Exp Rev Anti Infect Ther. 2012;10:1165-1176.
  16. Kot B. Antibiotic resistance among uropathogenic Escherichia coli. Pol J Microbiol. 2019;68:403-415.
  17. Werneburg GT. Catheter-associated urinary tract infections: current challenges and future prospects. Res Reports Urology. 2022;14:109-133.
  18. Sora VM, et al. Extraintestinal pathogenic Escherichia coli: virulence factors and antibiotic resistance. Pathogens. 2021;10:1355.
  19. Robino L, et al. Intracellular bacteria in the pathogenesis of Escherichia coli urinary tract infection in children. Clin Infect Dis. 2014;59:e158-e164.
  20. Thänert R et al. Comparative genomics of antibiotic-resistant uropathogens implicates three routes for recurrence of urinary tract infections. mBio. 2019;10:e01977-19.
  21. Malbon K et al. Should a neonate with possible late onset infection always have a lumbar puncture? Arch Dis Child. 2006;87:548.
  22. Selby LM. Prevention of Central-Line Associated Bloodstream Infections: 2021 Update. Infectious Disease Clinics of North America. 2021; 35: 841-856.
  23. Meletis G. Carbapenem resistance: overview of the problem and future perspectives. Ther Adv Infect Dis. 2016;3:15-21.
  24. Frenck RW, et al. Safety and immunogenicity of a vaccine for extra-intestinal pathogenic Escherichia coli (ESTELLA): a phase 2 randomised controlled trial. Lancet Infect Dis. 2019;19:631-640.
  25. Aziminia N, et al. Vaccines for the prevention of recurrent urinary tract infections: a systematic review. BJU Int. 2019;123:753-768.
  26. Poolman JT et al. Extraintestinal pathogenic Escherichia coli, a common human pathogen: challenges for vaccine development and progress in the field. J Infect Dis. 2016;213:6-13.
  27. Bert F et al. Genetic diversity and virulence profiles of Escherichia coli isolates causing spontaneous bacterial peritonitis and bacteremia in patients with cirrhosis. J Clin Microbiol. 2010;48:2709-2714.
« Return to: Extraintestinal Pathogenic Escherichia coli (ExPEC): Test Your Knowledge!
  • Print