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      Monday, June 5, 2023
      News & Perspective Drugs & Diseases CME & Education Academy Video Decision Point
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      CME / ABIM MOC

      Mechanosensation by Endothelial PIEZO1 Is Required for Leukocyte Diapedesis

      • Authors: ShengPeng Wang, PhD; Bianbian Wang, MS; Yue Shi, MS; Tanja Möller; Rebekka I. Stegmeyer, MS; Boris Strilic, PhD; Zuyi Yuan, MD, PhD; Changhe Wang, PhD; Nina Wettschureck, MD; Dietmar Vestweber, PhD; Stefan Offermanns, MD
      • CME / ABIM MOC Released: 7/21/2022
      • Valid for credit through: 7/21/2023
      Start Activity

      • Credits Available

        Physicians - maximum of 1.00 AMA PRA Category 1 Credit(s)™

        ABIM Diplomates - maximum of 1.00 ABIM MOC points

        You Are Eligible For

        • Letter of Completion
        • ABIM MOC points

      Target Audience and Goal Statement

      This activity is intended for hematologists and other specialists in pathophysiologic mechanisms underlying inflammatory and infectious disease.

      The goal of this activity is for learners to be better able to describe how molecular mechanisms underlying the initial interactions between leukocytes and endothelial cells are linked to opening of the endothelial barrier, based on a mouse model.

      Upon completion of this activity, participants will:

      1. Describe how low flow and leukocyte-induced intercellular adhesion molecule 1 clustering interact to mechanically activate endothelial PIEZO1, based on a mouse model
      2. Identify the role of PIEZO1 activation in signaling processes leading to opening of the endothelial barrier and leukocyte extravasation, based on a mouse model
      3. Determine pathophysiologic and clinical implications of how molecular mechanisms underlying the initial interactions between leukocytes and endothelial cells are linked to opening of the endothelial barrier, based on a mouse model

      Disclosures

      Medscape, LLC requires every individual in a position to control educational content to disclose all financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

      All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated according to Medscape policies. Others involved in the planning of this activity have no relevant financial relationships.

      Faculty

      • ShengPeng Wang, PhD

        Department of Cardiology
        First Affiliated Hospital
        Cardiovascular Research Center
        School of Basic Medical Sciences
        Xi'an Jiaotong University
        Xi’an, China
        Max Planck Institute for Heart and Lung Research
        Department of Pharmacology
        Bad Nauheim, Germany

      • Bianbian Wang, MS

        Center for Mitochondrial Biology and Medicine
        School of Life Science and Technology
        Xi’an Jiaotong University
        Xi’an, China

      • Yue Shi, MS

        Department of Cardiology
        First Affiliated Hospital
        Cardiovascular Research Center
        School of Basic Medical Sciences
        Xi'an Jiaotong University
        Xi’an, China
        Max Planck Institute for Heart and Lung Research
        Department of Pharmacology
        Bad Nauheim, Germany

      • Tanja Möller

        Department of Vascular Cell Biology
        Max Planck Institute for Molecular Biomedicine
        Muenster, Germany

      • Rebekka I. Stegmeyer, MS

        Department of Vascular Cell Biology
        Max Planck Institute of Molecular Biomedicine
        Muenster, Germany

      • Boris Strilic, PhD

        Max Planck Institute for Heart and Lung Research
        Department of Pharmacology
        Bad Nauheim, Germany

      • Ting Li, MS

        Department of Cardiology
        First Affiliated Hospital
        Cardiovascular Research Center
        School of Basic Medical Sciences
        Xi'an Jiaotong University
        Xi’an, China

      • Zuyi Yuan, MD, PhD

        Department of Cardiology
        First Affiliated Hospital, Cardiovascular Research Center
        School of Basic Medical Sciences
        Xi'an Jiaotong University
        Xi’an, China

      • Changhe Wang, PhD

        Center for Mitochondrial Biology and Medicine
        School of Life Science and Technology
        Xi’an Jiaotong University
        Xi’an, China

      • Nina Wettschureck, MD

        Max Planck Institute for Heart and Lung Research
        Department of Pharmacology
        Bad Nauheim, Germany
        Center for Molecular Medicine
        Goethe University Frankfurt
        Frankfurt, Germany
        Cardiopulmonary Institute
        Bad Nauheim, Germany
        German Center for Cardiovascular Research (DZHK)
        Rhine-Main site
        Frankfurt and Bad Nauheim, Germany

      • Dietmar Vestweber, PhD

        Department of Vascular Cell Biology
        Max Planck Institute for Molecular Biomedicine
        Muenster, Germany

      • Stefan Offermanns, MD

        Department of Pharmacology
        Max Planck Institute for Heart and Lung Research
        Bad Nauheim, Germany
        Center for Molecular Medicine
        Goethe University Frankfurt
        Frankfurt, Germany
        Cardiopulmonary Institute
        Bad Nauheim, Germany
        German Center for Cardiovascular Research (DZHK)
        Rhine-Main site
        Frankfurt and Bad Nauheim, Germany

      CME Author

      • Laurie Barclay, MD

        Freelance writer and reviewer
        Medscape, LLC

        Disclosures

        Disclosure: Laurie Barclay, MD, has disclosed the following relevant financial relationships:
        Formerly owned stocks in: AbbVie

      Editor

      • Thomas D. Coates

         Associate Editor, Blood

      Compliance Reviewer

      • Leigh A. Schmidt, MSN, RN, CMSRN, CNE, CHCP

        Associate Director, Accreditation and Compliance
        Medscape, LLC

        Disclosures

        Disclosure: Leigh A. Schmidt, MSN, RN, CMSRN, CNE, CHCP, has disclosed no relevant financial relationships.

      Accreditation Statements



      In support of improving patient care, this activity has been planned and implemented by Medscape, LLC and the American Society of Hematology. Medscape, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

        For Physicians

      • Medscape, LLC designates this Journal-based CME activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

        Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

        Contact This Provider

      For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]

      Instructions for Participation and Credit

      There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

      This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 75% on the post-test.

      Follow these steps to earn CME/CE credit*:

      1. Read about the target audience, learning objectives, and author disclosures.
      2. Study the educational content online or print it out.
      3. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

      You may now view or print the certificate from your CME/CE Tracker. You may print the certificate, but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period, you can print out the tally as well as the certificates from the CME/CE Tracker.

      *The credit that you receive is based on your user profile.

      From Blood
      CME / ABIM MOC

      Mechanosensation by Endothelial PIEZO1 Is Required for Leukocyte Diapedesis

      Authors: ShengPeng Wang, PhD; Bianbian Wang, MS; Yue Shi, MS; Tanja Möller; Rebekka I. Stegmeyer, MS; Boris Strilic, PhD; Zuyi Yuan, MD, PhD; Changhe Wang, PhD; Nina Wettschureck, MD; Dietmar Vestweber, PhD; Stefan Offermanns, MDFaculty and Disclosures

      CME / ABIM MOC Released: 7/21/2022

      Valid for credit through: 7/21/2023

      processing....

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