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Making Waves in Major Depressive Disorder

  • Authors: Anita H. Clayton, MD; Vladimir Maletic, MD; Michael E. Thase, MD
  • CME / ABIM MOC / CE Released: 7/8/2022
  • Valid for credit through: 7/8/2023, 11:59 PM EST
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Target Audience and Goal Statement

This activity is intended for psychiatrists, primary care physicians (PCPs), pediatricians, nurses, nurse practitioners (NPs), and physician assistants (PAs). 

The goal of this activity is that learners will be better able to screen, diagnose, and manage patients with major depressive disorder (MDD).

Upon completion of this activity, participants will:

  • Have increased knowledge regarding
    • Strategies to overcome barriers to optimal management of patients with treatment-resistant depression (TRD)   
    • Clinical data on novel and emerging treatments for MDD 
  • Have greater competence related to
    • Implementing measurement-based care in MDD management


Medscape, LLC requires every individual in a position to control educational content to disclose all financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated according to Medscape policies. Others involved in the planning of this activity have no relevant financial relationships.

Disclosures for additional planners can be found here.


  • Anita H. Clayton, MD

    David C. Wilson Professor and Chair 
    Department of Psychiatry and Neurobehavioral Sciences 
    Clinical Obstetrics and Gynecology 
    University of Virginia 
    Charlottesville, Virginia 


    Anita H. Clayton, MD, has the following relevant financial relationships:  
    Consultant or advisor for: AbbVie; Acadia; Alkermes; Allergan; AMAG Pharmaceuticals; Astellas; Brii Biosciences; Fabre-Kramer; Field Trip Health; Janssen Research & Development; Mind Cure Health; Ovoca Bio, plc; Praxis Precision Medicines; PureTech Health; S1 Biopharma; Sage Therapeutics; Takeda/Lundbeck; Vella Bioscience, Inc; WCG MedAvante-ProPhase 
    Research funding from: Daré Bioscience; Endoceutics, Inc; Janssen; Praxis Precision Medicines; Relmada Therapeutics, Inc.; Sage Therapeutics 
    Stock options from: Euthymics; S1 Biopharma 

  • Vladimir Maletic, MD

    Clinical Professor of Psychiatry 
    USC School of Medicine 
    Greenville, South Carolina 


    Vladimir Maletic, MD, has the following relevant financial relationships:  
    Consultant or advisor for: AbbVie/Allergan; Acadia; Alfasigma USA, Inc.; Alkermes; Eisai; Intra-Cellular Therapies; Ironshore; Janssen; Lundbeck; Jazz Pharmaceuticals; Noven Pharmaceuticals, Inc; Otsuka America Pharmaceutical, Inc.; Sage Pharmaceuticals; Sunovion; Supernus Pharmaceuticals, Inc.; Takeda 
    Speaker or member of speakers bureau for: AbbVie; Acadia; Alkermes; Allergan; Eisai; Ironshore; Intra-Cellular; Janssen; Lundbeck; Otsuka America Pharmaceutical, Inc.; Sunovion; Supernus Pharmaceuticals, Inc.; Takeda 

  • Michael E. Thase, MD

    Professor, Department of Psychiatry 
    Mood and Anxiety Disorders Treatment and Research Program 
    University of Pennsylvania 
    Perelman School of Medicine 
    Corporal Michael J. Crescenz  
    Veterans Affairs Medical Center 
    Philadelphia, Pennsylvania  


    Michael E. Thase, MD, has the following relevant financial relationships:  
    Consultant or advisor for: Acadia; Akili, Inc.; Alkermes; Allergan; Axsome Therapeutics, Inc.; BioHaven, Inc.; Bocemtium Consulting, S.L.; Boehringer Ingelheim International; CatalYm GmbH; Clexio Biosciences; Gerson Lehrman Group, Inc.; Jazz Pharmaceuticals; Janssen; Johnson & Johnson; Lundbeck; Luye Pharma Group, Ltd.; Merck & Company, Inc.; Otsuka Pharmaceutical Company, Ltd.; Pfizer, Inc.; Sage Pharmaceuticals; Seelos Pharmaceuticals; Sunovion; Takeda 
    Research funding from: Acadia; Allergan; AssureRx Health; Axsome Therapeutics, Inc.; BioHaven, Inc.; Intra-Cellular Therapies, Inc.; Johnson & Johnson; Otsuka Pharmaceutical Company, Ltd.; Takeda 


  • John Churchwell, PhD

    Medical Education Director, Medscape, LLC


    John Churchwell, PhD, has the following relevant financial relationships: he was employed by Medtronic (ended 2021)

Compliance Reviewer/Nurse Planner

  • Stephanie Corder, ND, RN, CHCP

    Associate Director, Accreditation and Compliance, Medscape, LLC 


    Stephanie Corder, ND, RN, CHCP, has no relevant financial relationships. 

Peer Reviewer

This activity has been peer reviewed and the reviewer has no relevant financial relationships.

Accreditation Statements


Interprofessional Continuing Education

In support of improving patient care, Medscape, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


This activity was planned by and for the healthcare team, and learners will receive 1.50 Interprofessional Continuing Education (IPCE) credit for learning and change.

    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 1.50  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.50 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

    Contact This Provider

    For Nurses

  • Awarded 1.50 contact hour(s) of continuing nursing education for RNs and APNs; 1.0 contact hours are in the area of pharmacology.

    Contact This Provider

For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]

Instructions for Participation and Credit

There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 75% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read the target audience, learning objectives, and author disclosures.
  2. Study the educational content online or printed out.
  3. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period you can print out the tally as well as the certificates from the CME/CE Tracker.

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Making Waves in Major Depressive Disorder

Authors: Anita H. Clayton, MD; Vladimir Maletic, MD; Michael E. Thase, MDFaculty and Disclosures

CME / ABIM MOC / CE Released: 7/8/2022

Valid for credit through: 7/8/2023, 11:59 PM EST


Contents of This CME Activity

All sections of this activity are required for credit.

Using Your Toolbox: Measurement-Based Care in MDD

Learn how measurement-based care can lead to better outcomes for patients with MDD.
Anita H. Clayton, MD

What's After Number One and Number Two? Treatment Resistance in MDD

Learn how to tackle treatment-resistant depression and review strategic care approaches.
Michael E. Thase, MD

MDD: Advancements in Therapy

Learn about mechanisms underlying MDD and the emerging treatments that affect system neurobiology.
Vladimir Maletic, MD​

Educational Impact Challenge

The goal of this activity is that learners will be better able to screen, diagnose, and manage patients with major depressive disorder (MDD).

Before you begin this activity, please assess your clinical knowledge by completing this brief survey. Answering these questions again after the activity will allow you to see what you learned and to compare your answers with those of your peers.

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