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Opening the Window of Opportunity in Treating Crohn's Disease

  • Authors: Miguel Regueiro, MD; Uma Mahadevan, MD; Siddharth Singh, MD
  • CME / ABIM MOC / CE Released: 6/27/2022
  • Valid for credit through: 6/27/2023, 11:59 PM EST
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Target Audience and Goal Statement

This activity is intended for gastroenterologists, primary care physicians, and other clinicians who treat patients with Crohn's disease (CD). 

The goal of this activity is that learners will be better able to improve the risk stratification of patients with CD; increase recognition of treatment opportunity prior to bowel damage and disability; and improve the selection of treatments that will help achieve and maintain remission via a shared decision-making approach between clinicians and patients.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Treat-to-target principles for managing CD
  • Have greater competence related to
    • Identifying patients with CD who would benefit from early aggressive treatment to prevent disease progression
    • Incorporating clinical decision tools into treatment decisions for CD
    • Designing treatment strategies that include patients' preferences and goals
  • Demonstrate greater confidence in their ability to
    • Optimize the management of CD based on patient risk stratification/clinical factors and patient preference


Medscape, LLC requires every individual in a position to control educational content to disclose all financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated according to Medscape policies. Others involved in the planning of this activity have no relevant financial relationships.


  • Miguel Regueiro, MD

    Chair, Digestive Disease and Surgery Institute
    Chair, Department of Gastroenterology, Hepatology & Nutrition
    The Pier C. and Renee A. Borra Family Endowed Chair in
    Gastroenterology and Hepatology
    Professor, Department of Medicine
    Cleveland Clinic Lerner College of Medicine of
    Case Western Reserve University
    Cleveland, Ohio


    Miguel Regueiro, MD, has the following relevant financial relationships:
    Consultant or advisor for: AbbVie; ALFASIGMA, S.p.A.; Allergan; Amgen; Celgene; Genentech; Gilead; Janssen; Lilly; Miraca Labs; Pfizer; Pharma Solutions; Prometheus; Salix; Seres; Takeda; UCB
    Speaker or member of speakers bureau for: Cornerstones; Imedex; MJH Life Sciences; Remedy
    Research funding from: AbbVie; Janssen; Pfizer; Takeda


  • Uma Mahadevan, MD

    Professor of Medicine
    Director, UCSF Colitis and Crohn’s Disease Center
    San Francisco, California


    Uma Mahadevan, MD, has the following relevant financial relationships:
    Consultant or advisor for: AbbVie; Arena; Boehringer Ingelheim; Bristol Myers Squibb; Gilead; Janssen; Pfizer; Takeda

  • Siddharth Singh, MD

    Associate Professor of Medicine
    Director UCSD IBD Center
    University of California San Diego
    La Jolla, California


    Siddharth Singh, MD, has the following relevant financial relationships:
    Research funding from: AbbVie; Janssen; Pfizer
    Other: Ad hoc grant review: Pfizer


  • Briana Betz, PhD

    Medical Education Director, WebMD Global, LLC 


    Briana Betz, PhD, has no relevant financial relationships.

Compliance Reviewer/Nurse Planner

  • Leigh Schmidt, MSN, RN, CMSRN, CNE, CHCP

    Associate Director, Accreditation and Compliance, Medscape, LLC



    Leigh Schmidt, MSN, RN, CMSRN, CNE, CHCP, has no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has no relevant financial relationships.

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Interprofessional Continuing Education

In support of improving patient care, Medscape, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

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    For Nurses

  • Awarded 1.0 contact hour(s) of nursing continuing professional development for RNs and APNs; 0.50 contact hours are in the area of pharmacology.

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For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]

Instructions for Participation and Credit

There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 75% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read the target audience, learning objectives, and author disclosures.
  2. Study the educational content online or printed out.
  3. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period you can print out the tally as well as the certificates from the CME/CE Tracker.

*The credit that you receive is based on your user profile.


Opening the Window of Opportunity in Treating Crohn's Disease

Authors: Miguel Regueiro, MD; Uma Mahadevan, MD; Siddharth Singh, MDFaculty and Disclosures

CME / ABIM MOC / CE Released: 6/27/2022

Valid for credit through: 6/27/2023, 11:59 PM EST


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