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Gastroenteropancreatic Neuroendocrine Tumor Vignettes: Can You Manage These Patients Effectively?

  • Authors: Jonathan Strosberg, MD
  • CME / ABIM MOC Released: 6/27/2022
  • Valid for credit through: 6/27/2023, 11:59 PM EST
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Target Audience and Goal Statement

This activity is intended for oncologists, gastroenterologists, surgeons, pathologists, endocrinologists, radiologists, and other healthcare providers on the multidisciplinary care team.

The goal of this activity is to help learners as members of the multidisciplinary team more effectively diagnose and manage patients with GEP-NETs.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Clinical trial data evaluating treatment options for patients with GEP-NETs
    • Characteristics that guide treatment selection for patients with GEP-NETs
  • Have greater competence related to
    • Creating a personalized care plan for patients with GEP-NETs
    • Mitigating treatment-related adverse events in patients receiving therapy for GEP-NETs
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    • Work as members of the multidisciplinary care team to optimize the care of patients with GEP-NETs


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  • Jonathan Strosberg, MD

    Section Head, Neuroendocrine Oncology
    Moffitt Cancer Center
    Tampa, Florida, United States


    Jonathan Strosberg, MD, has the following relevant financial relationships:
    Consultant or advisor for: Tersera
    Speaker or member of speakers bureau for: Ipsen
    Research funding from: ITM; Merck; Novartis


  • Charlotte Warren

    Senior Director, Content Development, Medscape, LLC 


    Charlotte Warren has no relevant financial relationships.

  • Jason Luis Quiñones, PhD

    Scientific Content Manager, Medscape, LLC 


    Jason Luis Quiñones, PhD, has no relevant financial relationships.

  • Tristin Abair, PhD

    Senior Medical Writer, WebMD Global, LLC 


    Tristin Abair, PhD, has no relevant financial relationships.

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  • Yaisanet Oyola, MD

    Associate Director, Accreditation and Compliance, Medscape, LLC


    Yaisanet Oyola, MD, has no relevant financial relationships.

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This activity has been peer reviewed and the reviewer has no relevant financial relationships.

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Gastroenteropancreatic Neuroendocrine Tumor Vignettes: Can You Manage These Patients Effectively?

Authors: Jonathan Strosberg, MDFaculty and Disclosures

CME / ABIM MOC Released: 6/27/2022

Valid for credit through: 6/27/2023, 11:59 PM EST


The following cases are modeled on the interactive grand rounds approach. The questions within the activity are designed to test your current knowledge. After each question, you will be able to see whether you answered correctly and read evidence-based information that supports the most appropriate answer choice. The questions are designed to challenge you; you will not be penalized for answering the questions incorrectly. At the end of the activity, there will be a short post-test assessment based on the material presented.


Amanda is a 58-year-old mother of 2. She has mild hypertension that is well controlled with medication. She presented to her primary care provider with abdominal pain and reported a history of similar episodes every 2 months for the last year. Computed tomography (CT) scans shows multiple ill-defined lesions in the liver and a short area of thickening in the distal small intestine. Liver biopsy revealed a well-differentiated neuroendocrine tumor, with a Ki-67 index of 6%.

Table 1. Amanda's Initial Workup

Patient information

  • Aged 58 y
  • Height: 5'4"
  • Weight: 162 lb
  • BMI: 27.8

Personal and family medical history

  • History of mild hypertension; no other health issues
  • Current medications: lisinopril and a daily multivitamin
  • Nonsmoker; consumes 1-2 alcoholic beverages/wk
  • No allergies
  • No family history of cancer

Physical exam

  • Tenderness in upper abdomen
  • ECOG PS: 0

Laboratory evaluations

  • CBC normal
  • CMP shows mild elevation of AST
AST = aspartate transaminase; BMI = body mass index; CBC = complete blood cell count; CMP = comprehensive metabolic panel; ECOG = Eastern Cooperative Oncology Group; PS = performance status.
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