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Lung Transplant Rejection: Micro Learnings on Advances in Surveillance Technology

  • Authors: Brian Keller, MD, PhD; Sean Agbor-Enoh, MD, PhD; Deborah Jo Levine, MD, FCCP, FEST
  • CME Released: 4/22/2022
  • Valid for credit through: 4/22/2023
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  • Credits Available

    Physicians - maximum of 0.50 AMA PRA Category 1 Credit(s)™

    You Are Eligible For

    • Letter of Completion

Target Audience and Goal Statement

This activity is intended for pulmonologists, transplant surgeons, and other HCPs who work with patients who have received a lung transplant.

The goal of this activity is to improve knowledge around current standards for acute and chronic rejection monitoring and increase understanding of the clinical trial data on donor-derived cell-free DNA (dd-cfDNA) for transplant rejection monitoring.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Mechanisms of acute lung transplant rejection
    • Mechanisms of chronic lung transplant rejection
    • Limitations of current standards in posttransplant surveillance
    • Clinical trial data on dd-cfDNA as a biomarker for lung transplant rejection
    • Role of emerging technologies in differentiating posttransplant infection from rejection


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All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated according to Medscape policies. Others involved in the planning of this activity have no relevant financial relationships.



  • Brian Keller, MD, PhD

    Associate Professor
    Department of Internal Medicine
    Division of Pulmonary, Critical Care and Sleep Medicine
    The Ohio State University College of Medicine
    Columbus, Ohio


    Disclosure: Brian Keller, MD, PhD, has the following relevant financial relationships:
    Consultant or advisor for: CareDx
    Speaker or member of speakers bureau for: CareDx
    Research funding from: CareDx, Natera, Zambon Company S.P.A.

  • Sean Agbor-Enoh, MD, PhD

    Lab Chief
    NIH Lasker Clinical Tenure Track Investigator and NIH Distinguished Scholar
    Laboratory of Applied Precision Omics
    Division of Intramural Research
    National Heart, Lung, and Blood Institute
    National Institutes of Health
    Bethesda, Maryland
    Assistant Professor
    Lung Transplantation Program
    Pulmonary and Critical Care Medicine
    The Johns Hopkins Hospital
    Johns Hopkins School of Medicine
    Baltimore, Maryland
    Participation by Dr Agbor-Enoh does not constitute or imply endorsement by the Johns Hopkins University or the Johns Hopkins Hospital and Health System.


    Disclosure: Sean Agbor-Enoh, MD, PhD, has no relevant financial relationships.

  • Deborah Jo Levine, MD, FCCP, FEST

    Professor/Clinical Medical Director
    Lung Transplantation
    Pulmonary Hypertension Center
    The University of Texas Health Science Center at San Antonio
    San Antonio, Texas


    Disclosure: Deborah Jo Levine, MD, FCCP, FEST, has no relevant financial relationships.


  • Iwona Misiuta, PhD, MHA

    Medical Education Director, Medscape, LLC


    Disclosure: Iwona Misiuta, PhD, MHA, has no relevant financial relationships.

  • Yoji Yamaguchi, MA, ELS

    Scientific Content Manager, Medscape, LLC


    Disclosure: Yoji Yamaguchi, MA, ELS, has no relevant financial relationships.

Compliance Reviewer

  • Amanda Jett, PharmD, BCACP

    Associate Director, Accreditation and Compliance, Medscape, LLC


    Disclosure: Amanda Jett, PharmD, BCACP, has no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has disclosed no relevant financial relationships.

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    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

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This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 70% on the post-test.

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You may now view or print the certificate from your CME/CE Tracker. You may print the certificate, but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period, you can print out the tally as well as the certificates from the CME/CE Tracker.

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Lung Transplant Rejection: Micro Learnings on Advances in Surveillance Technology

Authors: Brian Keller, MD, PhD; Sean Agbor-Enoh, MD, PhD; Deborah Jo Levine, MD, FCCP, FESTFaculty and Disclosures

CME Released: 4/22/2022

Valid for credit through: 4/22/2023


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