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Gastroenteritis: A Review of Syndromic Testing and Ct Values Across Various GI Complications

  • Authors: Ferric C Fang, MD; Mini Kamboj, MD; Nathan Ledeboer, PhD; Andrew Pavia, MD
  • CME / ABIM MOC Released: 12/15/2022
  • Valid for credit through: 12/15/2023
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  • Credits Available

    Physicians - maximum of 0.75 AMA PRA Category 1 Credit(s)™

    ABIM Diplomates - maximum of 0.75 ABIM MOC points

    You Are Eligible For

    • Letter of Completion
    • ABIM MOC points

Target Audience and Goal Statement

This activity is intended for infectious disease specialists, gastroenterologists, and pediatricians.

The goal of this activity is that learners will be better able to improve clinicians’ understanding of how syndromic testing and cycle threshold (Ct) values can be used in the management of patients with gastroenteritis.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Key attributes of multiplex diagnostic technology used in the management of gastroenteritis
    • Role of Ct values in the management of patients with gastroenteritis
  • Have greater competence related to
    • Identifying patients for whom syndromic testing and evaluation of associated Ct values may be beneficial


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All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated according to Medscape policies. Others involved in the planning of this activity have no relevant financial relationships.


  • Andrew Pavia, MD

    Professor and Chief 
    Division of Pediatric Infectious Diseases 
    University of Utah
    Salt Lake City, Utah 


    Disclosure: Andrew Pavia, MD, has the following relevant financial relationships:
    Consultant or advisor for: GlaxoSmithKline

  • Ferric C Fang, MD

    Professor, Laboratory Medicine and Pathology, and Microbiology
    Adjunct Professor, Department of Medicine, Division of Allergy and Infectious Diseases
    Director, Harborview Medical Center Clinical Microbiology Laboratory 
    University of Washington School of Medicine 
    Seattle, Washington 


    Disclosure: Ferric C Fang, MD, has the following relevant financial relationships:
    Consultant or advisor for: BioFire Therapeutics; Thirty Technology

  • Mini Kamboj, MD

    Chief Medical Epidemiologist, Infection Control 
    Memorial Sloan Kettering Cancer Center 
    New York, New York 
    Department of Medicine 
    Weill Cornell Medical College, Cornell University 
    New York, New York 


    Disclosure: Mini Kamboj, MD, has no relevant financial relationships.

  • Nathan Ledeboer, PhD

    Professor and Vice Chair
    Department of Pathology and Laboratory Medicine 
    Medical College of Wisconsin 
    Milwaukee, Wisconsin  


    Disclosure: Nathan Ledeboer, PhD, has the following relevant financial relationships:
    Consultant or advisor for: Aerte; Agena; Copan; Karius; Lifescale; Luminex; Shionogi; ThermoFisher
    Research funding from: BD; bioMerieux; Cepheid; Diasorin; Exact Sciences; Genefluidics; Hardy; Hilbergene; Hologic; Lumira; Luminex; Meridian; Ortho; Quidel; Qiagen; Serosep; Talis
    Stock options from: CosmosID; Cytovale; Genecapture; Inflammatix
    Owns stock (publicly traded) in: Medtronic; Stryker


  • Maria Uravich, BSc, ELS

    Senior Medical Education Director, Medscape, LLC


    Disclosure: Maria Uravich, BSc, ELS, has no relevant financial relationships.

  • Jennifer Gregg, PhD

    Medical Education Director, Medscape, LLC


    Disclosure: Jennifer Gregg, PhD, has no relevant financial relationships.

Compliance Reviewer

  • Amanda Jett, PharmD, BCACP

    Associate Director, Accreditation and Compliance, Medscape, LLC


    Disclosure: Amanda Jett, PharmD, BCACP, has no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has no relevant financial relationships.

Accreditation Statements

In support of improving patient care, Medscape, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.75 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

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For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]

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This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 75% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read the target audience, learning objectives, and author disclosures.
  2. Study the educational content online or printed out.
  3. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period you can print out the tally as well as the certificates from the CME/CE Tracker.

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Gastroenteritis: A Review of Syndromic Testing and Ct Values Across Various GI Complications

Authors: Ferric C Fang, MD; Mini Kamboj, MD; Nathan Ledeboer, PhD; Andrew Pavia, MDFaculty and Disclosures

CME / ABIM MOC Released: 12/15/2022

Valid for credit through: 12/15/2023


Note: It is Medscape's policy to avoid the use of Brand names in accredited activities. However, in an effort to be as clear as possible, trade names are used in this activity to distinguish between the mixtures and different tests. It is not meant to promote any particular product. 

Contents of This CME Activity

All sections of this activity are required for credit.

Introduction – Overview of Syndromic Testing and the Role of Amplification Curves and Ct values​

Join Dr Fang for an introduction highlighting the role of syndromic testing and Ct values across various GI complications.
Ferric Fang, MD

Gastroenteritis in Children and the Use of Syndromic Panel Testing

Dr Pavia reviews the clinical significance of syndromic panel testing in children.
Andrew Pavia, MD

Gastroenteritis in Adults and Insights on Interpreting Syndromic Test Results

Dr Fang and Dr Kamboj offer insights on gastroenteritis in adults and the correlation between Ct values and C difficile infection.
Ferric Fang, MD and Mini Kamboj, MD

Determining Candidates for Syndromic Panels for Gastroenteritis

Dr Ledeboer provides insights on interpreting test results.
Nathan Ledeboer, PhD

Closing Thoughts on Syndromic Testing in GI Complications

Dr Fang wraps up with final thoughts on the implications of syndromic testing for clinical practice.
Ferric Fang, MD
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