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CME / ABIM MOC

Bruton Tyrosine Kinase Inhibitors in Chronic Lymphocytic Leukemia: Context and Impact of New Data

  • Authors: John Seymour, MD; Toby A. Eyre, MBChB, DipMedEd, MRCP, FRCPath, MD; Stephan Stilgenbauer, MD; Jennifer A. Woyach, MD
  • CME / ABIM MOC Released: 4/5/2022
  • THIS ACTIVITY HAS EXPIRED FOR CREDIT
  • Valid for credit through: 4/5/2023, 11:59 PM EST
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Target Audience and Goal Statement

This activity is intended for a global international audience of hematologists and oncologists who manage patients with B-cell malignancies.

The goal of this activity is for the learner to be better able to examine recent data with emerging Bruton tyrosine kinase (BTK) inhibitors and how this may necessitate changes in practice when managing patients with chronic lymphocytic leukemia (CLL).

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Current challenges with available BTK inhibitors in patients with B-cell malignancies
    • New clinical trial data investigating emerging BTK inhibitors that may impact future practice in managing patients with CLL
  • Demonstrate greater confidence in their ability to
    • Identify patients with CLL who could benefit from treatment with next-generation BTK inhibitors


Disclosures

Medscape, LLC requires every individual in a position to control educational content to disclose all financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated according to Medscape policies. Others involved in the planning of this activity have no relevant financial relationships.


Faculty

  • John Seymour, MD

    Professor and Director
    Department of Clinical Hematology
    Peter MacCallum Cancer Centre
    Royal Melbourne Hospital
    Melbourne, Australia

    Disclosures

    No relevant financial relationships

  • Toby A. Eyre, MBChB, DipMedEd, MRCP, FRCPath, MD

    Consultant Hematologist
    Oxford Cancer and Haematology Centre
    Churchill Hospital
    Oxford University Hospitals NHS Foundation Trust
    Oxford, United Kingdom

    Disclosures

    Consultant or advisor for: AbbVie, Inc.; AstraZeneca Pharmaceuticals LP; BeiGene (Beijing) Co., Ltd.; Gilead Sciences, Inc.; Incyte Corporation; Janssen; Kite Pharma, Inc.; Loxo Oncology; Roche; Secura
    Speaker or member of speakers bureau for: AbbVie, Inc.; AstraZeneca Pharmaceuticals LP; Gilead Sciences, Inc.; Incyte Corporation; Janssen; Kite Pharma, Inc.; Loxo Oncology; Roche; Takeda
    Research funding from: AstraZeneca Pharmaceuticals LP; BeiGene (Beijing) Co., Ltd.
    Contracted researcher for: Loxo Oncology

  • Stephan Stilgenbauer, MD

    Professor
    Medical Director
    Comprehensive Cancer Center Ulm
    Head
    Early Clinical Trials Unit
    Head
    Division of CLL
    Department of Internal Medicine III
    Ulm University
    Ulm, Germany

    Disclosures

    Consultant or advisor for: AbbVie, Inc.; Acerta Pharma; Amgen, Inc.; AstraZeneca Pharmaceuticals LP; BeiGene (Beijing) Co., Ltd.; Bristol Myers Squibb Company; Celgene Corporation; F. Hoffman-La Roche Ltd (Europe); Genentech; Gilead Sciences, Inc.; GlaxoSmithKline; Incyte Corporation; Infinity; Janssen; Novartis; Pharmacyclics, Inc.; Sunesis Pharmaceuticals, Inc.; Verastem, Inc.
    Speaker or member of speakers bureau for: AbbVie, Inc.; Acerta Pharma; Amgen, Inc.; AstraZeneca Pharmaceuticals LP; BeiGene (Beijing) Co., Ltd.; Bristol Myers Squibb Company; Celgene Corporation; F. Hoffman-La Roche Ltd (Europe); Genentech; Gilead Sciences, Inc.; GlaxoSmithKline; Incyte Corporation; Infinity; Janssen; Novartis; Pharmacyclics, Inc.; Sunesis Pharmaceuticals, Inc.; Verastem, Inc.
    Research funding from: AbbVie, Inc.; Acerta Pharma; Amgen, Inc.; AstraZeneca Pharmaceuticals LP; BeiGene (Beijing) Co., Ltd.; Bristol Myers Squibb Company; Celgene Corporation; F. Hoffman-La Roche Ltd (Europe); Genentech; Gilead Sciences, Inc.; GlaxoSmithKline; Incyte Corporation; Infinity; Janssen; Novartis; Pharmacyclics, Inc.; Sunesis Pharmaceuticals, Inc.; Verastem, Inc.
    Contracted researcher for: AbbVie, Inc.; Acerta Pharma; Amgen, Inc.; AstraZeneca Pharmaceuticals LP; BeiGene (Beijing) Co., Ltd.; Bristol Myers Squibb Company; Celgene Corporation; F. Hoffman-La Roche Ltd (Europe); Genentech; Gilead Sciences, Inc.; GlaxoSmithKline; Incyte Corporation; Infinity; Janssen; Novartis; Pharmacyclics, Inc.; Sunesis Pharmaceuticals, Inc.; Verastem, Inc.

  • Jennifer A. Woyach, MD

    Professor of Medicine
    Division of Hematology
    The Ohio State University Comprehensive Cancer Center
    Columbus, Ohio, United States

    Disclosures

    Consultant or advisor for: AbbVie, Inc.; AstraZeneca Pharmaceuticals LP; BeiGene (Beijing) Co., Ltd.; Genentech; Loxo Oncology; Newave; Pharmacyclics, Inc.
    Research funding from: Janssen; Karyopharm; MorphoSys; Pharmacyclics, Inc.
    Contracted researcher for: Schrodinger

Editors

  • Sanneke Koekkoek

    Medical Education Director, WebMD Global, LLC

    Disclosures

    Disclosure: Sanneke Koekkoek has disclosed no relevant financial relationships.

  • Chii Shyang Fong, PhD

    Scientific Content Manager, WebMD Global, LLC

    Disclosures

    Disclosure: Chii Shyang Fong, PhD, has no relevant financial relationships.

Compliance Reviewer

  • Stephanie Corder, ND, RN, CHCP

    Associate Director, Accreditation and Compliance, Medscape, LLC

    Disclosures

    Disclosure: Stephanie Corder, ND, RN, CHCP, has no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has no relevant financial relationships.


Accreditation Statements

Medscape

Interprofessional Continuing Education

In support of improving patient care, Medscape, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.50 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

    Contact This Provider

For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]


Instructions for Participation and Credit

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This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 100% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read the target audience, learning objectives, and author disclosures.

  2.  

    Study the educational content.

  3. Access the post-test webpage at the URL here medscape.org/anthology/alzheimers-timely-identification or via the provided QR code.

  4. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period you can print out the tally as well as the certificates from the CME/CE Tracker.

*The credit that you receive is based on your user profile.

CME / ABIM MOC

Bruton Tyrosine Kinase Inhibitors in Chronic Lymphocytic Leukemia: Context and Impact of New Data

Authors: John Seymour, MD; Toby A. Eyre, MBChB, DipMedEd, MRCP, FRCPath, MD; Stephan Stilgenbauer, MD; Jennifer A. Woyach, MDFaculty and Disclosures
THIS ACTIVITY HAS EXPIRED FOR CREDIT

CME / ABIM MOC Released: 4/5/2022

Valid for credit through: 4/5/2023, 11:59 PM EST

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Educational Impact Challenge

The goal of this activity is for the learner to be better able to examine recent data with emerging Bruton tyrosine kinase (BTK) inhibitors and how this may necessitate changes in practice when managing patients with chronic lymphocytic leukemia (CLL).

Before you begin this activity, please assess your clinical knowledge by completing this brief survey. Answering these questions again after the activity will allow you to see what you learned and to compare your answers with those of your peers.

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