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Treatment Decisions in Spinal Muscular Atrophy: Best Practices in Adolescent and Adult Patients

  • Authors: John W. Day, MD, PhD
  • CME / ABIM MOC / CE Released: 3/16/2022
  • Valid for credit through: 3/16/2023
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Target Audience and Goal Statement

This activity is intended for neurologists, pediatricians, primary care physicians, and nurses.

The goal of this activity is to increase clinician knowledge on clinical data of FDA-approved medications for adolescents and adults with spinal muscular atrophy (SMA) and to ensure the appropriate selection of medications for adolescents and adults with SMA.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Mechanism of action of FDA-approved medications for the management of SMA
    • Clinical data on the use of FDA-approved medications for SMA in adolescents and adults
  • Have greater competence related to
    • Selection of an appropriate medication for the management of SMA in adolescents and adults


Medscape, LLC requires every individual in a position to control educational content to disclose all financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated according to Medscape policies. Others involved in the planning of this activity have no relevant financial relationships.


  • John W. Day, MD, PhD

    Professor of Neurology, Pediatrics-Medical Genetics, and (by courtesy) Pathology
    Director, Neuromuscular Division and Clinics
    Stanford University
    Palo Alto, California


    Disclosure: John Day, MD, PhD, has the following relevant financial relationships:
    Advisor or consultant for: Affinia Therapeutics; Astellas Pharma; Avidity; Biogen; Cytokinetics; Ionis Pharmaceuticals; Novartis Gene Therapies; PepGen; Pfizer; Roche/Genentech; Sarepta Therapeutics; Scholar Rock
    Grants for clinical research from: AMO Pharma; Astellas; Avidity; Biogen; Ionis Pharmaceuticals; Cytokinetics; Novartis Gene Therapies; Roche Pharmaceuticals; Sanofi-Genzyme; Sarepta Therapeutics; Scholar Rock
    Royalties or patent beneficiary: Athena Diagnostics for Genetic Testing (US Patents 7442782 and 7527931)


  • Pakinam Aboulsaoud, PharmD

    Medical Education Director, Medscape, LLC


    Disclosure: Pakinam Aboulsaoud, PharmD, has disclosed no relevant financial relationships.

Compliance Reviewer

  • Yaisanet Oyola, MD

    Associate Director, Accreditation and Compliance, Medscape, LLC 


    Disclosure: Yaisanet Oyola, MD, has no relevant financial relationships. 

Nurse Planner

  • Stephanie Corder, ND, RN, CHCP

    Associate Director, Accreditation and Compliance, Medscape, LLC 


    Disclosure: Stephanie Corder, ND, RN, CHCP, has no relevant financial relationships. 

Peer Reviewer

This activity has been peer reviewed and the reviewer has no relevant financial relationships.

Accreditation Statements

Developed through a partnership between Medscape and Cure SMA.

In support of improving patient care, Medscape, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.50 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

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    For Nurses

  • Awarded 0.50 contact hour(s) of nursing continuing professional development for RNs and APNs; 0.50 contact hours are in the area of pharmacology.

    Contact This Provider

For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]

Instructions for Participation and Credit

There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 75% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read the target audience, learning objectives, and author disclosures.
  2. Study the educational content online or printed out.
  3. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period you can print out the tally as well as the certificates from the CME/CE Tracker.

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Treatment Decisions in Spinal Muscular Atrophy: Best Practices in Adolescent and Adult Patients

Authors: John W. Day, MD, PhDFaculty and Disclosures

CME / ABIM MOC / CE Released: 3/16/2022

Valid for credit through: 3/16/2023


Assessment Survey

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