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Manipulating the Disrupted Sleep-Wake Cycle in Insomnia

  • Authors: Göran Hajak, MD, PhD, MBA
  • CME / ABIM MOC / CE Released: 3/17/2022
  • Valid for credit through: 3/17/2023, 11:59 PM EST
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Target Audience and Goal Statement

This educational activity is intended for a US and European audience of primary care physicians, psychiatrists, neurologists, and nurses.

The goal of this activity is to familiarize clinicians with how the sleep-wake system is being therapeutically targeted in insomnia.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Roles of different neurotransmitter systems in the sleep-wake cycle
    • Targeting of neurotransmitter systems by therapeutics for insomnia 


Medscape, LLC requires every individual in a position to control educational content to disclose all financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated according to Medscape policies. Others involved in the planning of this activity have no relevant financial relationships.


  • Göran Hajak, MD, PhD, MBA

    Professor of Psychiatry
    University of Regensburg
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy
    Social Foundation Bamberg, Germany


    Independent contractor for: CGC Consulting
    Advisor or consultant for: Heel; Idorsia; Janssen-Cilag; Jazz; Recordati; Rovi; Sanofi; Servier
    Speaker or member of speakers bureau for: Bristol Myers Squibb; Gedeon Richter; Heel; Hexal; Idorsia; Janssen-Cilag; Jazz; Lundbeck; Medice; Medfora; Medau; Neuraxpharm; Pfizer; Recordati; Repha; Rovi; Sanofi; Schwabe; Servier; Zeller


  • Katherine Carpenter, PhD

    Medical Education Director, WebMD Global, LLC


    Disclosure: Katherine Carpenter, PhD, has the following relevant financial relationships
    Advisor or consultant for: Eisai, GW Pharmaceuticals

Compliance Reviewer/Nurse Planner

  • Leigh Schmidt, MSN, RN, CMSRN, CNE, CHCP

    Associate Director, Accreditation and Compliance, Medscape, LLC


    Disclosure: Leigh Schmidt, MSN, RN, CMSRN, CNE, CHCP, has no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has no relevant financial relationships.

Accreditation Statements


Interprofessional Continuing Education

In support of improving patient care, Medscape, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.25 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

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    For Nurses

  • Awarded 0.25 contact hour(s) of nursing continuing professional development for RNs and APNs; 0.25 contact hours are in the area of pharmacology.

    Contact This Provider

For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]

Instructions for Participation and Credit

There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 75% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read the target audience, learning objectives, and author disclosures.
  2. Study the educational content online or printed out.
  3. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period you can print out the tally as well as the certificates from the CME/CE Tracker.

*The credit that you receive is based on your user profile.


Manipulating the Disrupted Sleep-Wake Cycle in Insomnia

Authors: Göran Hajak, MD, PhD, MBAFaculty and Disclosures

CME / ABIM MOC / CE Released: 3/17/2022

Valid for credit through: 3/17/2023, 11:59 PM EST


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