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Challenging Cases in Alzheimer’s Disease: Applying Strategies to Inform Timely and Accurate Diagnosis

  • Authors: Richard Isaacson, MD; Larry Culpepper, MD, MPH; Henrik Zetterberg, MD, PhD​
  • CME / ABIM MOC / CE Released: 2/24/2022
  • Valid for credit through: 2/24/2023, 11:59 PM EST
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Target Audience and Goal Statement

This activity is intended for primary care physicians, neurologists, nurses (including internal medicine, family practice, geriatric medicine), AD specialists, dementia specialists, neurologists, nurse practitioners, and physician assistants.

The goal of this activity is to increase ability of clinicians to identify and assess patients suspected of having mild cognitive impairment.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Tools for evaluating cognitive impairment in clinical practice
  • Have greater competence related to
    • Recognition of early signs and symptoms of mild cognitive impairment
  • Demonstrate greater confidence in their ability to
    • Perform an evaluation in patients suspected of having AD


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All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated according to Medscape policies. Others involved in the planning of this activity have no relevant financial relationships.

Disclosures for additional planners can be found here.


  • Richard Isaacson, MD

    Director of the Alzheimer’s Prevention Clinic
    Florida Atlantic University Schmidt College of Medicine
    Boca Raton, Florida, United States​
    Adjunct Associate Professor of Neurology
    Weill Cornell Medicine
    New York, New York​, United States


    Advisor or consultant for: Acadia; Avandia; Biogen; Genentech/Roche; Lilly; Novo Nordisk
    Speaker or member of speakers bureau:  Biogen

  • Larry Culpepper, MD, MPH

    Professor of Family Medicine
    Boston University School of Medicine
    Dept. of Family Medicine
    Boston, Massachusetts, United States


    Advisor or consultant for: AbbVie Pharmaceuticals; Acadia Pharmaceuticals; Allergan Pharmaceuticals; Eisai Pharmaceuticals; Supernus Pharmaceuticals Inc.; Takeda Pharmaceuticals
    Owns stock:  M-3 Information, LLC.

  • Henrik Zetterberg, MD, PhD

    Professor of Neurochemistry​
    Chief Physician​
    Institute of Neuroscience and Physiology
    Sahlgrenska Academy
    University of Gothenburg
    Mölndal, Sweden​


    Advisor or consultant for: Abbvie; Alector; Annexon; Artery Therapeutics; AZTherapies; CogRx; Denali; Eisai; Nervgen; Pinteon Therapeutics; Red Abbey Labs; Passage Bio; Roche; Samumed; Siemens Healthineers; Triplet Therapeutics; Wave
    Speaker or member of speakers bureau for: Alzecure; Biogen; Cellectricon; Fujirebio; Roche


  • Lisette Arnaud-Hevi, PhD

    Medical Education Director, Medscape, LLC 


    Disclosure: Lisette Arnaud-Hevi, PhD, has no relevant financial relationships. 

Compliance Reviewer/Nurse Planner

  • Leigh Schmidt, MSN, RN, CMSRN, CNE, CHCP

    Associate Director, Accreditation and Compliance, Medscape, LLC 


    Disclosure: Leigh Schmidt, MSN, RN, CMSRN, CNE, CHCP, has disclosed no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has no relevant financial relationships.

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    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.75 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

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    For Nurses

  • Awarded 0.75 contact hour(s) of nursing continuing professional development for RNs and APNs; 0 contact hours are in the area of pharmacology.

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This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 75% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read the target audience, learning objectives, and author disclosures.
  2. Study the educational content online or printed out.
  3. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

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Challenging Cases in Alzheimer’s Disease: Applying Strategies to Inform Timely and Accurate Diagnosis

Authors: Richard Isaacson, MD; Larry Culpepper, MD, MPH; Henrik Zetterberg, MD, PhD​Faculty and Disclosures

CME / ABIM MOC / CE Released: 2/24/2022

Valid for credit through: 2/24/2023, 11:59 PM EST


Contents of This CME Activity

All sections of this activity are required for credit.

The journey along the pathophysiological–clinical AD continuum

Dr Isaacson provides a brief overview of the initial clinical symptoms and pathophysiological mechanisms of AD.
Richard Isaacson, MD

Signs, Symptoms, and Evaluation of MCI

Dr Culpepper presents some of the instruments PCPs can use to rapidly assess if a patient with cognitive decline goes beyond normal aging.
Larry Culpepper, MD, MPH

What Should Trigger Suspicion of MCI and How To Perform an Evaluation for AD

Dr Isaacson and Dr Zetterberg compare the steps and tools to achieve a differential diagnosis of MCI due to AD in the US and EU.
Richard Isaacson, MD, and Henrik Zetterberg, MD, PhD

Educational Impact Challenge

The goal of this activity is to increase ability of clinicians to identify and assess patients suspected of having mild cognitive impairment.

Before you begin this activity, please assess your clinical knowledge by completing this brief survey. Answering these questions again after the activity will allow you to see what you learned and to compare your answers with those of your peers.

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