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Homozygous Familial Hypercholesterolemia: Improving Detection and Clinical Management

  • Authors: Frederick J. Raal, MMED, PhD
  • CME / ABIM MOC Released: 1/19/2022
  • Valid for credit through: 1/19/2023
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Target Audience and Goal Statement

This activity is intended for cardiologists, primary care physicians, pediatricians, nurse practitioners, and physician assistants involved in the care of patients with homozygous familial hypercholesterolemia (HoFH).

The goal of this activity is to increase awareness related to the prevalence of HoFH, share strategies for early recognition, and delve into treatments including the newest lipid-lowering agents.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Identification of patients with HoFH
    • Latest HoFH lipid-lowering treatment options
    • Initiation of appropriate treatment strategies in individual patients with HoFH to meet lipid-lowering goals


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All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated according to Medscape policies. Others involved in the planning of this activity have no relevant financial relationships.


  • Frederick J. Raal (Derick), MMED, PhD

    Director, Carbohydrate & Lipid Metabolism Research Unit
    Professor & Head, Division of Endocrinology & Metabolism
    Faculty of Health Sciences, University of the Witwatersrand
    Johannesburg, South Africa


    Disclosure: Frederick J. Raal(Derick), MMED, PhD, has disclosed the following relevant financial relationships:
    Grants for clinical research from: Amgen; Novartis; Regeneron; Sanofi
    Advisor or consultant for: Amgen; Novartis; Regeneron; Sanofi
    Speaker or member of speakers bureau for: Amgen; Novartis; Regeneron; Sanofi


  • Joy P. Marko, MS, APN-C, CCMEP

    Senior Medical Education Director, Medscape, LLC


    Disclosure: Joy P. Marko, MS, APN-C, CCMEP, has disclosed no relevant financial relationships.

Compliance Reviewer

  • Robert Morris, PharmD

    Associate Director, Accreditation and Compliance, Medscape, LLC


    Disclosure: Robert Morris, PharmD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: ViiV Healthcare
    Owns stock, stock options, or bonds from: GlaxoSmithKline

Peer Reviewer

This activity has been peer reviewed and the reviewer has disclosed no relevant financial relationships.

Accreditation Statements

In support of improving patient care, Medscape, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.25 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

    Contact This Provider

For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]

Instructions for Participation and Credit

There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 70% on the post-test.

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  1. Read about the target audience, learning objectives, and author disclosures.
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Homozygous Familial Hypercholesterolemia: Improving Detection and Clinical Management

Authors: Frederick J. Raal, MMED, PhDFaculty and Disclosures

CME / ABIM MOC Released: 1/19/2022

Valid for credit through: 1/19/2023


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