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Fibrodysplasia Ossificans Progressiva: On the Cusp of a Change in Management -- New Guidelines, New Care Pathways

  • Authors: Robert J. Pignolo, MD, PhD; Patricia L.R. Delai, MD; Clive S. Friedman, BDS (Diplomate AAPD)
  • CME Released: 1/4/2022
  • Valid for credit through: 1/4/2023, 11:59 PM EST
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Target Audience and Goal Statement

This educational activity is intended for an international audience of pediatricians, orthopedists, orthopedic surgeons, hematology/oncology specialists, medical geneticists, and endocrinologists.

The goal of this activity is to highlight important recommendations from the 2021 fibrodysplasia ossificans progressiva (FOP) guidelines and how those recommendations apply to care pathways for routine practice.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Diagnostic criteria for FOP, based on current guidelines
    • Guideline-based management of FOP
    • Advice that should be provided to patients with FOP


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Medscape, LLC encourages Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration, at first mention and where appropriate in the content.


  • Robert J. Pignolo, MD, PhD

    Robert and Arlene Kogod Professor of Geriatric Medicine
    Mayo Clinic School of Medicine
    Rochester, Minnesota, United States


    Disclosure: Robert J. Pignolo, MD, PhD, has the following relevant financial relationships:
    Advisor or consultant for: Incyte; Ipsen Pharmaceuticals; Native Technologies; Regeneron Pharmaceuticals
    Grants for clinical research from: Genome Protection, Inc.; Ipsen Pharmaceuticals; Regeneron Pharmaceuticals

  • Patricia L.R. Delai, MD

    Professor of Rare Diseases
    Dental and Medical School
    São Leopoldo Mandic
    Hospital Israelita Albert Einstein
    Medical Advisor
    Brazilian FOP Association
    São Paulo, Brazil


    Disclosure: Patricia L.R. Delai, MD, has the following relevant financial relationships:
    Other: Principal investigator for clinical trial from Ipsen Pharmaceuticals

  • Clive S. Friedman, BDS (Diplomate AAPD)

    Assistant Clinical Professor
    Schulich School of Medicine and Dentistry
    Pediatric Oral Health and Dentistry
    London, Ontario, Canada   


    Disclosure: Clive S. Friedman, BDS (Diplomate AAPD), has the following relevant financial relationships:
    Advisor or consultant for: Ipsen Pharmaceuticals
    Grants for clinical research from: Ipsen Pharmaceuticals


  • Walid Amara, MD

    Medical Education Director, WebMD Global, LLC


    Disclosure: Walid Amara, MD, has no relevant financial relationships.

CME Reviewer

  • Robert Morris, PharmD

    Associate Director, Accreditation and Compliance, Medscape, LLC


    Disclosure: Robert Morris, PharmD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: ViiV Healthcare
    Owns stock, stock options, or bonds from: GlaxoSmithKline

None of the nonfaculty planners for this educational activity have relevant financial relationship(s) to disclose with ineligible companies whose primary business is producing, marketing, selling, reselling, or distributing healthcare products used by or on patients.

Peer Reviewer

This activity has been peer reviewed and the reviewer has disclosed no relevant financial relationships.

Accreditation Statements


Interprofessional Continuing Education

In support of improving patient care, Medscape, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Contact This Provider

For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]

Instructions for Participation and Credit

There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 75% on the post-test.

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Fibrodysplasia Ossificans Progressiva: On the Cusp of a Change in Management -- New Guidelines, New Care Pathways

Authors: Robert J. Pignolo, MD, PhD; Patricia L.R. Delai, MD; Clive S. Friedman, BDS (Diplomate AAPD)Faculty and Disclosures

CME Released: 1/4/2022

Valid for credit through: 1/4/2023, 11:59 PM EST


A Powerpoint version of the slides from this presentation
is available for use as a professional resource from Medscape Education.

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