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State of the Art Approaches to Sequencing DMTs in MS

  • Authors: Thomas P. Leist, MD, PhD; Riley M. Bove, MD, MMSc
  • CME / ABIM MOC Released: 12/10/2021
  • Valid for credit through: 12/10/2022
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Target Audience and Goal Statement

This activity is intended for neurologists, primary care physicians, obstetricians & gynecologists, nurses and nurse practitioners.

The goal of this activity is to increase awareness of factors involved in personalizing the selection of specific disease-modifying therapies (DMTs) at specific points in disease in individual patients.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Clinical data relating to the timing of when to start a DMT after the onset of multiple sclerosis (MS) symptoms
    • The impact of patient-related factors in the selection of a DMT for the management of MS
    • Factors involved in the determination that a change to another DMT for the management of MS should be considered


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Medscape, LLC encourages Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration, at first mention and where appropriate in the content.


  • Thomas P. Leist, MD, PhD

    Professor of Neurology
    Chief, Division of Clinical Neuroimmunology
    Director, Comprehensive Multiple Sclerosis Center
    Thomas Jefferson University
    Philadelphia, Pennsylvania


    Disclosure: Thomas P. Leist, MD, PhD, has the following relevant financial relationships:
    Advisor or consultant for: Biogen; EMDSerono; Genentech; Horizon; Novartis
    Speaker or a member of a speakers bureau for: Biogen; Bristol Myers Squibb; EMDSerono; Genentech; Horizon
    Grants for clinical research from: AbbVie; Biogen; Bristol Myers Squibb; EMDSerono; Genentech; Novartis

  • Riley M. Bove, MD, MMSc

    Associate Professor of Neurology
    UCSF Weill Institute for Neurosciences
    Director of Digital Innovation
    UCSF Center for MS and Neuroinflammation
    University of California, San Francisco
    San Francisco, California


    Disclosure: Riley M. Bove, MD, MMSc, has the following relevant financial relationships:
    Advisor or consultant for: Alexion; Biogen; EMDSerono; Novartis; Roche Genentech; Sanofi Genzyme
    Grants for clinical research from: Biogen; Novartis; Roche Genentech


  • Lisette Arnaud-Hevi, PhD

    Medical Education Director, Medscape, LLC


    Disclosure: Lisette Arnaud-Hevi, PhD, has disclosed no relevant financial relationships.

CME Reviewer

  • Amanda Jett, PharmD, BCACP

    Associate Director, Accreditation and Compliance, Medscape, LLC


    Disclosure: Amanda Jett, PharmD, BCACP, has disclosed no relevant financial relationships.

None of the nonfaculty planners for this educational activity have relevant financial relationship(s) to disclose with ineligible companies whose primary business is producing, marketing, selling, reselling, or distributing healthcare products used by or on patients.

Peer Reviewer

This activity has been peer reviewed and the reviewer has disclosed no relevant financial relationships.

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  • Medscape, LLC designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.50 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

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State of the Art Approaches to Sequencing DMTs in MS

Authors: Thomas P. Leist, MD, PhD; Riley M. Bove, MD, MMScFaculty and Disclosures

CME / ABIM MOC Released: 12/10/2021

Valid for credit through: 12/10/2022



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