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A Fresh Look at Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Diagnosis and Management of a Multisystem Illness

  • Authors: Benjamin Natelson, MD; Donna Felsenstein, MD; Mitchell Miglis, MD; Dale Strasser, MD
  • CME / ABIM MOC / CE Released: 12/21/2021; Reviewed and Renewed: 12/21/2022
  • Valid for credit through: 12/21/2023, 11:59 PM EST
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  • Credits Available

    Physicians - maximum of 0.50 AMA PRA Category 1 Credit(s)™

    ABIM Diplomates - maximum of 0.50 ABIM MOC points

    Nurses - 0.50 ANCC Contact Hour(s) (0 contact hours are in the area of pharmacology)

    Pharmacists - 0.50 Knowledge-based ACPE (0.050 CEUs)

    You Are Eligible For

    • Letter of Completion
    • ABIM MOC points

Target Audience and Goal Statement

This activity is intended for primary care physicians, nurses, nurse practitioners, and other healthcare providers (HCPs) involved in the diagnosis and management of myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS).

The goal of this activity is to increase awareness of the symptoms, diagnosis, and management of ME/CFS.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Impact of ME/CFS on multiple body systems
    • Symptom recognition of ME/CFS
  • Have greater competence related to
    • Individualizing a treatment plan to manage symptoms associated with ME/CFS


As an organization accredited by the ACCME, Medscape, LLC requires everyone who is in a position to control the content of an education activity to disclose all relevant financial relationships with any commercial interest. The ACCME defines "relevant financial relationships" as financial relationships in any amount, occurring within the past 12 months, including financial relationships of a spouse or life partner, that could create a conflict of interest.

Medscape, LLC encourages Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration, at first mention and where appropriate in the content.


  • Benjamin Natelson, MD

    Professor of Neurology
    Director, Pain & Fatigue Study Center
    Icahn School of Medicine at Mount Sinai
    New York, New York


    Disclosure: Benjamin Natelson, MD, has disclosed no relevant financial relationships.


  • Donna Felsenstein, MD

    Assistant Professor of Medicine
    Harvard Medical School
    Physician in Medicine
    Massachusetts General Hospital
    Boston, Massachusetts


    Disclosure: Donna Felsenstein, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Gerson Lehman Group

  • Mitchell Miglis, MD

    Clinical Associate Professor
    Neurology and Neurological Sciences
    Autonomic Division
    Psychiatry and Behavioral Sciences
    Sleep Medicine Division
    Stanford University
    Stanford, California


    Disclosure: Mitchell Miglis, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Guidepoint; Infinite MD; 2nd MD
    Served as a speaker or a member of a speakers bureau for: MED-IQ

  • Dale Strasser, MD

    Professor Emeritus of Rehabilitation Medicine
    Emory University School of Medicine
    Atlanta, Georgia

    The opinions expressed are those of Dr Strasser and do not necessarily reflect the views of Emory University or Emory Healthcare. Dr Strasser’s participation in this activity does not constitute or imply endorsement by Emory University or Emory Healthcare.


    Disclosure: Dale Strasser, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Avanir Pharmaceuticals; Reed Smith, LLC


  • Pakinam Aboulsaoud, PharmD

    Medical Education Director, Medscape, LLC 


    Disclosures: Pakinam Aboulsaoud, PharmD, disclosed no relevant financial relationships.  

CME, CE Reviewer/Nurse Planner

  • Stephanie Corder, ND, RN, CHCP

    Associate Director, Accreditation and Compliance, Medscape, LLC


    Disclosure: Stephanie Corder, ND, RN, CHCP, has disclosed no relevant financial relationships.

None of the nonfaculty planners for this educational activity have relevant financial relationship(s) to disclose with ineligible companies whose primary business is producing, marketing, selling, reselling, or distributing healthcare products used by or on patients.

Accreditation Statements


Interprofessional Continuing Education

In support of improving patient care, Medscape, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.50 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

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    For Nurses

  • Awarded 0.50 contact hour(s) of nursing continuing professional development for RNs and APNs; 0 contact hours are in the area of pharmacology.

    Contact This Provider

    For Pharmacists

  • Medscape designates this continuing education activity for 0.50 contact hour(s) (0.050 CEUs) (Universal Activity Number: JA0007105-0000-21-577-H01-P).

    Contact This Provider

For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]

Instructions for Participation and Credit

There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit(s)™, you must receive a minimum score of 75% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read about the target audience, learning objectives, and author disclosures.
  2. Study the educational content online or print it out.
  3. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate, but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period, you can print out the tally as well as the certificates from the CME/CE Tracker.

*The credit that you receive is based on your user profile.


A Fresh Look at Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Diagnosis and Management of a Multisystem Illness


Educational Impact Challenge

The goal of this activity is to increase awareness of the symptoms, diagnosis, and management of ME/CFS.

Before you begin this activity, please assess your clinical knowledge by completing this brief survey. Answering these questions again after the activity will allow you to see what you learned and to compare your answers with those of your peers.

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