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Understanding the Clinical Value of Ki67 in Hormone Receptor Positive and HER2-Negative Early Breast Cancer

  • Authors: Joyce A. O’Shaughnessy, MD
  • CME / ABIM MOC Released: 12/1/2021
  • Valid for credit through: 12/1/2022
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Target Audience and Goal Statement

This activity is intended for hematologists/oncologists, pathologists, and surgeons.

The goal of this activity is to provide oncologists with a greater understanding of the utility of Ki67 as a biomarker for hormone receptor positive (HR+)/HER2 negative (HER2-) early breast cancer care, including considerations for testing and interpreting results.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Value of Ki67 as a biomarker in hormone receptor positive (HR+)/HER2 negative (HER2-) early breast cancer 
    • Best practices for testing, interpreting, and reporting the results of Ki67 testing in the clinic 


As an organization accredited by the ACCME, Medscape, LLC requires everyone who is in a position to control the content of an education activity to disclose all relevant financial relationships with any commercial interest. The ACCME defines "relevant financial relationships" as financial relationships in any amount, occurring within the past 12 months, including financial relationships of a spouse or life partner, that could create a conflict of interest.

Medscape, LLC encourages Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration, at first mention and where appropriate in the content.


  • Joyce A. O’Shaughnessy, MD

    Celebrating Women Chair in Breast Cancer Research
    Baylor University Medical Center
    Director, Breast Cancer Research Program
    Texas Oncology
    US Oncology
    Dallas, Texas


    Disclosure: Joyce A. O’Shaughnessy, MD, has the following relevant financial relationships: 
    Advisor or consultant for: AbbVie Inc.; Agendia; Amgen Inc.; Aptitude Health; AstraZeneca; Bayer; Bristol Myers Squibb; Celgene; Clovis Oncology; Daiichi Sankyo; Eisai; G1 Therapeutics; Genentech; Gilead Sciences; GRAIL; Halozyme Therapeutics; Heron Therapeutics; Immunomedics; Ipsen Biopharmaceuticals; Eli Lilly and Company; Merck; Myriad Genetics; Nektar Therapeutics; Novartis; Ontada; Pfizer; Pharmacyclics; Pierre Fabre Pharmaceuticals; Puma Biotechnology; Prime Oncology; Roche; Samsung Bioepis Co, Ltd.; Sanofi; Seagen Inc.; Syndax Pharmaceuticals Inc.; Taiho Oncology; Takeda; Synthon
    Speaker or a member of a speakers bureau for: AstraZeneca; Pfizer; Seagen Inc.


  • Victoria Phoenix, BS

    Medical Education Director, Medscape, LLC 


    Disclosure: Victoria Phoenix, BS, has disclosed no relevant financial relationships.

  • Tristin Abair, PhD

    Senior Medical Writer, WebMD Global, LLC 


    Disclosure: Tristin Abair, PhD, has disclosed no relevant financial relationships.  

CME Reviewer

  • Robert Morris, PharmD

    Associate Director, Accreditation and Compliance, Medscape, LLC


    Disclosure: Robert Morris, PharmD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: ViiV Healthcare
    Owns stock, stock options, or bonds from: GlaxoSmithKline 

None of the nonfaculty planners for this educational activity have relevant financial relationship(s) to disclose with ineligible companies whose primary business is producing, marketing, selling, reselling, or distributing healthcare products used by or on patients.

Peer Reviewer

This activity has been peer reviewed and the reviewer has disclosed no relevant financial relationships.

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In support of improving patient care, Medscape LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.25 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

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Understanding the Clinical Value of Ki67 in Hormone Receptor Positive and HER2-Negative Early Breast Cancer

Authors: Joyce A. O’Shaughnessy, MDFaculty and Disclosures

CME / ABIM MOC Released: 12/1/2021

Valid for credit through: 12/1/2022


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