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CME / ABIM MOC

The Complement Pathway and Renal Dysfunction: From Pathophysiology to Therapeutic Targets

  • Authors: Giuseppe Remuzzi, MD; Richard Burwick, MD, MPH; Christopher C. Dvorak, MD; Carla M. Nester, MD, MSA, FASN; Eric Rondeau, MD
  • CME / ABIM MOC Released: 11/18/2020
  • THIS ACTIVITY HAS EXPIRED FOR CREDIT
  • Valid for credit through: 11/18/2021, 11:59 PM EST
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Target Audience and Goal Statement

This activity is intended for hem/onc specialists, nephrologists, and pediatricians.

The goal of this activity is to increase awareness and understanding about ongoing research into how targeting the complement pathway can address the underlying dysfunction in a variety of different renal disorders.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Role of the complement pathway in renal disorders
    • Targets in the complement pathway for the treatment of atypical hemolytic uremic syndrome (aHUS)
    • Molecular targets in the complement pathway undergoing evaluation for the prevention of preeclampsia
    • Molecular targets in the complement pathway for the treatment of transplant-associated thrombotic microangiopathy (TA-TMA)


Disclosures

As an organization accredited by the ACCME, Medscape, LLC, requires everyone who is in a position to control the content of an education activity to disclose all relevant financial relationships with any commercial interest. The ACCME defines "relevant financial relationships" as financial relationships in any amount, occurring within the past 12 months, including financial relationships of a spouse or life partner, that could create a conflict of interest.

Medscape, LLC, encourages Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration, at first mention and where appropriate in the content.


Faculty

  • Giuseppe Remuzzi, MD

    Professor of Nephrology​
    Director, Department of Immunology and Clinical Transplantation​
    Director, Division of Nephrology and Dialysis​
    Bergamo Hospital​
    Bergamo, Italy

    Disclosures

    Disclosure: Giuseppe Remuzzi, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Akebia Therapeutics; Alexion Pharmaceuticals; Janssen Pharmaceuticals; Omeron
    Served as a speaker or a member of a speakers bureau for: Alexion Pharmaceuticals; Alnylam; Boehringer Ingelheim; Handok
    Inc.; Inception Sciences Canada; Janssen Pharmaceuticals; Omeros
    Received grants for clinical research from: Achillion Pharmaceuticals; Novartis

  • Richard Burwick, MD, MPH

    Assistant Professor​
    Department of Obstetrics & Gynecology​
    Division of Maternal Fetal Medicine; Cedars-Sinai Medical Center​
    Cedars-Sinai Medical Center​
    Los Angeles, California, United States

    Disclosures

    Disclosure: Richard Burwick, MD, MPH, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Alexion Pharmaceuticals
    Served as a speaker or a member of a speakers bureau for: Alexion Pharmaceuticals
    Received grants for clinical research from: Alexion Pharmaceuticals

  • Chrsitopher C. Dvorak, MD

    Professor of Clinical Pediatrics​
    Division of Pediatric Blood and Marrow Transplantation​
    UCSF Benioff Children’s Hospital​
    San Francisco, California, United States

    Disclosures

    Disclosure: Christopher C. Dvorak, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Alexion Pharmaceuticals; Omeros Corp.

  • Carla M. Nester, MD, MSA, FASN​

    Jean E. Robillard MD, Chair in Pediatric Nephrology​
    Director, Division of Pediatric Nephrology, Dialysis and Transplantation​
    Associate Director, Molecular Otolaryngology and Renal Research Laboratory​
    Iowa City, Iowa

    Disclosures

    Disclosure: Carla M. Nester, MD, MSA, FASN, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Achillion Pharmaceuticals; Alexion Pharmaceuticals; BioCryst; Novartis
    Received grants for clinical research from: Achillion Pharmaceuticals; Alexion Pharmaceuticals; BioCryst; ChemoCentryx; Novartis; Retrophin

  • Eric Rondeau, MD

    Professor​
    Sorbonne Université​
    Intensive Care Nephrology and Transplantation Department​
    Tenon Hospital​
    Paris, France

    Disclosures

    Disclosure: Eric Rondeau, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Alexion Pharmaceutical
    Served as a speaker or a member of a speakers bureau for: Alexion Pharmaceuticals

Editors

  • Anne M. Sendaydiego, PharmD

    Medical Education Director, WebMD Global, LLC

    Disclosures

    Disclosure: Anne M. Sendaydiego, PharmD, has disclosed no relevant financial relationships.

  • Walid Amara, MD

    Medical Education Director, WebMD Global, LLC

    Disclosures

    Disclosure: Walid Amara, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: BIOTRONIK; Servier
    Served as a speaker or a member of a speakers bureau for: Amgen, Bayer HealthCare Pharmaceuticals; Boehringer Ingelheim Pharmaceuticals, Inc.; Boston Scientific; Bristol-Myers Squibb Company; Daiichi Sankyo, Inc.; Livanova; MEDA; Medtronic, Inc.; MSD; Novartis; Pfizer Inc.; Physiomed; St. Jude, Servier

CME Reviewer

  • Esther Nyarko, PharmD

    Associate Director, Accreditation and Compliance, Medscape, LLC

    Disclosures

    Disclosure: Esther Nyarko, PharmD, has disclosed no relevant financial relationships.

Medscape, LLC staff have disclosed that they have no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has disclosed no relevant financial relationships.


Accreditation Statements

Medscape

Interprofessional Continuing Education

In support of improving patient care, Medscape LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.75 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

    Contact This Provider

For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]


Instructions for Participation and Credit

There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 70% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read the target audience, learning objectives, and author disclosures.
  2. Study the educational content online or printed out.
  3. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period you can print out the tally as well as the certificates from the CME/CE Tracker.

*The credit that you receive is based on your user profile.

CME / ABIM MOC

The Complement Pathway and Renal Dysfunction: From Pathophysiology to Therapeutic Targets

Authors: Giuseppe Remuzzi, MD; Richard Burwick, MD, MPH; Christopher C. Dvorak, MD; Carla M. Nester, MD, MSA, FASN; Eric Rondeau, MDFaculty and Disclosures
THIS ACTIVITY HAS EXPIRED FOR CREDIT

CME / ABIM MOC Released: 11/18/2020

Valid for credit through: 11/18/2021, 11:59 PM EST

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Contents of This CME Activity

 

All sections of this activity are required for credit.

The Complement Pathway and Its Role in Renal Disorders

Dr Remuzzi discusses how the dysregulation of the complement pathway is involved in the different renal disorders.
Giuseppe Remuzzi, MD

The Complement Pathway and aHUS

Dr Rondeau discusses complement dysregulations in aHUS and their practical therapeutic implications.
Eric Rondeau, MD

The Complement Pathway and TA-TMA

Dr Dvorak discusses complement dysregulations in TA-TMA and their practical therapeutic implications.
Christopher C. Dvorak, MD

The Complement Pathway and C3 Glomerulopathy

Dr Nester discusses complement dysregulations in C3 glomerulopathy and their practical therapeutic implications.
Carla M. Nester, MD, MSA, FASN

Complement Dysregulation in Preeclampsia

Dr Burwick discusses complement dysregulation in preeclampsia.
Richard Burwick, MD, MPH
 
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