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Case Studies: The Role of BTK Inhibitors in CLL and MCL

  • Authors: Jennifer Brown, MD, PhD; Constantine Tam, MB, BS (hons), MD, FRACP, FRCPA
  • CME / ABIM MOC Released: 11/12/2020
  • Valid for credit through: 11/12/2021
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Target Audience and Goal Statement

This activity is intended for hematology/oncology specialists.

The goal of this activity is to improve clinicians' knowledge about Bruton tyrosine kinase (BTK) inhibitors used for the treatment of chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) and their skills in managing treatment-related side effects.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Approved indications for available BTK inhibitors
  • Have greater competence related to
    • Managing the side effects of BTK inhibitors
  • Demonstrate greater confidence in their ability to
    • Identify side effects of BTK inhibitors


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Medscape, LLC encourages Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration, at first mention and where appropriate in the content.


  • Jennifer R. Brown, MD, PhD

    Director of the CLL Center
    Division of Hematologic Malignancies
    Dana-Farber Cancer Institute
    Professor of Medicine
    Harvard Medical School
    Boston, Massachusetts


    Disclosure: Jennifer R. Brown, MD, PhD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Abbvie; Acerta; AstraZeneca; Beigene; Catapult; Eli Lilly; MEI Pharma; Novartis; Octapharma; Pfizer; Rigel
    Served as a speaker or a member of a speakers bureau for: Gilead; Loxo; Sun; Verastem
    Other: DSMB: Invectys

  • Constantine Tam, MB, BS (Hons), MD, FRACP, FRCPA

    Professor of Haematology
    University of Melbourne
    Consultant Haematologist
    Lead for CLL and Low Grade Lymphoma Service
    Peter MacCallum Cancer Center
    Royal Melbourne Hospital
    Melbourne, Australia


    Disclosure: Constantine Tam, MB, BS (Hons), MD, FRACP, FRCPA, has disclosed the following relevant financial relationships:
    Received grants for clinical research from: AbbVie; Janssen
    Other: Honoraria from AbbVie; Beigene; Janssen


  • Mindy Tanzola, PhD

    Medical Education Director, Medscape, LLC


    Disclosure: Mindy Tanzola, PhD, has disclosed no relevant financial relationships.

CME Reviewer

  • Robert Morris, PharmD

    Associate Director, Accreditation and Compliance, Medscape, LLC


    Disclosure: Robert Morris, PharmD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: ViiV Healthcare
    Owns stock, stock options, or bonds from: GlaxoSmithKline

Medscape, LLC staff have disclosed that they have no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has disclosed no relevant financial relationships.

Accreditation Statements

In support of improving patient care, Medscape LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.50 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

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Case Studies: The Role of BTK Inhibitors in CLL and MCL

Authors: Jennifer Brown, MD, PhD; Constantine Tam, MB, BS (hons), MD, FRACP, FRCPAFaculty and Disclosures

CME / ABIM MOC Released: 11/12/2020

Valid for credit through: 11/12/2021