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When the Going Gets Tough: Treating Chronic Idiopathic Constipation – Clinical Forum

  • Authors: Brooks D. Cash, MD, AGAF, FACG, FACP, FASGE (Chair); Darren M. Brenner, MD, FACG, AGAF; Lucinda A. Harris, MS, MD
  • CME Released: 9/30/2020
  • Valid for credit through: 9/30/2021
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Target Audience and Goal Statement

This activity was developed for physicians and other healthcare professionals treating patients with chronic idiopathic constipation (CIC).

The goal of this activity is to explore the pathophysiology of chronic idiopathic constipation (CIC), discuss key data on prescription CIC therapies, and debate crucial questions in the development and personalization of treatment plans for patients with CIC.

Learning Objectives

Upon completion of this activity, participants will be able to:

  • Describe the underlying pathophysiology of chronic idiopathic constipation (CIC)
  • Apply key data on the benefits and risks of available therapies for the treatment of CIC
  • Develop evidence-based treatment plans with clear goals and coordinated care for individuals with CIC


It is the policy of AKH Inc., Advancing Knowledge in Healthcare and RMEI Medical Education, LLC to ensure independence, balance, objectivity, scientific rigor, and integrity in all of their continuing education activities. The faculty must disclose to the participants any significant relationships with commercial interests whose products or devices may be mentioned in the activity or with the commercial supporter of this continuing education activity. Identified conflicts of interest are resolved by RMEI and AKH prior to accreditation of the activity and may include any of, or a combination of, the following: attestation to non-commercial content; notification of independent and certified CME expectations; referral to National Faculty Initiative training; restriction of topic area or content; restriction to discussion of science only; amendment of content to eliminate discussion of device or technique; use of other faculty for discussion of recommendations; independent review against criteria ensuring evidence supports the recommendation; moderator review; and peer review. AKH planners and reviewers have no relevant financial relationships to disclose. RMEI Medical Education, LLC planners and reviewers have no relevant financial relationships to disclose.

This course is designed solely to provide the healthcare professional with information to assist in his/her practice and professional development and is not to be considered a diagnostic tool to replace professional advice or treatment. The course serves as a general guide to the healthcare professional and, therefore, cannot be considered as giving legal, nursing, medical, or other professional advice in specific cases. AKH Inc. specifically disclaim responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through participant's misunderstanding of the content.

This educational activity may include discussion of uses of agents that are investigational and/or unapproved by the FDA. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


  • Brooks D. Cash, MD, AGAF, FACG, FACP, FASGE (Chair)

    Dan and Lillie Sterling Professor of Gastroenterology
    Chief, Gastroenterology, Hepatology, and Nutrition Division
    Director, Gastrointestinal Physiology Laboratory
    Memorial Hermann Hospital, Texas Medical Center
    University of Texas Health Science Center at Houston
    McGovern Medical School
    Houston, Texas


    Brooks D. Cash, MD, AGAF, FACG, FACP, FASGE, has affiliations with Allergan, Salix, Takeda (Consultant and Speakers Bureau).

  • Darren M. Brenner, MD, FACG, AGAF

    Associate Professor, Medicine and Surgery
    Irene D. Pritzker Foundation Research Scholar
    Director, Northwestern Neurogastromotility and Functional Bowel Programs
    Director, Motts Tonelli GI Physiology Laboratory
    Northwestern University – Feinberg School of Medicine
    Chicago, Illinois


    Darren M. BrennerMD, FACG, AGAF, has affiliations with Allergan (AbbVie), Alnylam, Alphasigma, Arena, Bayer, Ironwood, Salix, Takeda (Consultant); Allergan (AbbVie), Ironwood, Salix, Takeda (Speakers Bureau).

  • Lucinda A. Harris, MS, MD

    Associate Professor, Medicine
    Consultant, Division of Gastroenterology & Hepatology
    Department of Medicine
    Mayo Clinic
    Scottsdale, Arizona


    Lucinda A. Harris, MS, MD, has affiliations with Allergan, Ironwood, Salix, Takeda (Consultant).

AKH & RMEI Medical Education, LLC Staff and Planners

Lobna M. Eldasher, PharmD - RMEI Medical Director, has no financial relationships to disclose.

Sharon Powell - RMEI Senior Medical Editor, has no financial relationships to disclose.

Dorothy Caputo, MA, BSN, RN, AKH Director of Accreditation, Planner, has no financial relationships to disclose.

Patricia Brignoni, AKH Director of Operations, has no financial relationships to disclose.

Accreditation Statements

Jointly provided by AKH Inc., Advancing Knowledge in Healthcare and RMEI Medical Education, LLC.

    For Physicians

  • This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of AKH Inc., Advancing Knowledge in Healthcare and RMEI Medical Education, LLC. AKH Inc., Advancing Knowledge in Healthcare is accredited by the ACCME to provide continuing medical education for physicians.

    AKH Inc., Advancing Knowledge in Healthcare designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Physician Assistants

    NCCPA accepts AMA PRA Category 1 Credit™ from organizations accredited by ACCME.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1 MOC points and 0 patient safety MOC credit in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

    If you have questions about this CME activity, please contact AKH Inc. at [email protected].

    Contact This Provider

For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]

Instructions for Participation and Credit

There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 70% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read the target audience, learning objectives, and author disclosures.
  2. Study the educational content online or printed out.
  3. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period you can print out the tally as well as the certificates from the CME/CE Tracker.

*The credit that you receive is based on your user profile.


When the Going Gets Tough: Treating Chronic Idiopathic Constipation – Clinical Forum

Authors: Brooks D. Cash, MD, AGAF, FACG, FACP, FASGE (Chair); Darren M. Brenner, MD, FACG, AGAF; Lucinda A. Harris, MS, MDFaculty and Disclosures

CME Released: 9/30/2020

Valid for credit through: 9/30/2021


Before you begin, please answer the questions in this brief questionnaire.

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