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Metabolic Acidosis: What's the Latest?

  • Authors: Donald E. Wesson, MD; Navdeep Tangri, MD, PhD
  • CME / ABIM MOC Released: 9/17/2020
  • Valid for credit through: 9/17/2021, 11:59 PM EST
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Target Audience and Goal Statement

This activity is intended for nephrologists and primary care physicians.

The goal of this activity is to help keep clinicians, including those who care for patients with chronic kidney disease (CKD), abreast of new data related to the treatment of metabolic acidosis (MA).

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Safety and efficacy of available and emerging MA treatment options
    • Emerging treatment strategies that may improve patient outcomes in MA


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Medscape, LLC, encourages Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration, at first mention and where appropriate in the content.


  • Donald E. Wesson, MD

    Donald E. Wesson Consulting, LLC
    Professor of Medicine
    Texas A&M College of Medicine
    Dallas, Texas, United States


    Disclosure: Donald E. Wesson, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Tricida, Inc.
    Served as a speaker or a member of a speakers bureau for: Tricida, Inc.


  • Navdeep Tangri, MD, PhD

    Associate Professor
    University of Manitoba
    Manitoba, Winnipeg, Canada


    Disclosure: Navdeep Tangri, MD, PhD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Akebia; AstraZeneca; Boehringer Ingelheim-Lilly; Janssen; Mesentech; Otsuka; Pulsedata; Roche; Tricida, Inc.
    Served as a speaker or a member of a speakers bureau for: Janssen
    Received grants for clinical research from: AstraZeneca; Janssen; Tricida, Inc.
    Owns stock, stock options, or bonds from: Mesentech; Pulsedata; Tricida, Inc.


  • Meghan Coulehan, MPH

    Senior Director, Clinical Content Development, Medscape, LLC


    Disclosure: Meghan Coulehan, MPH, has disclosed no relevant financial relationships.

  • Anita A. Galdieri, PharmD, RPh

    Senior Scientific Content Manager, Medscape, LLC


    Disclosure: Anita A. Galdieri, PharmD, RPh, has disclosed no relevant financial relationships.

CME Reviewer

  • Hazel Dennison, DNP, RN, FNP, CHCP, CPHQ, CNE

    Associate Director, Accreditation and Compliance, Medscape, LLC


    Disclosure: Hazel Dennison, DNP, RN, FNP, CHCP, CPHQ, CNE, has disclosed no relevant financial relationships.

Medscape, LLC staff have disclosed that they have no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has disclosed no relevant financial relationships.

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    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.50 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

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Metabolic Acidosis: What's the Latest?

Authors: Donald E. Wesson, MD; Navdeep Tangri, MD, PhDFaculty and Disclosures

CME / ABIM MOC Released: 9/17/2020

Valid for credit through: 9/17/2021, 11:59 PM EST


ACE = angiotensin-converting enzyme
ACR = albumin-to-creatinine ratio
ARB = angiotensin receptor blocker
CAD = coronary artery disease
CHF = congestive heart failure
CKD = chronic kidney disease
Cl = chloride
CO2 = carbon dioxide
CV = cardiovascular
CVD = cardiovascular disease
eGFR = estimated glomerular filtration rate
GFR = glomerular filtration rate
GI = gastrointestinal
HbA1c = glycated hemoglobin
ICD = International Classification of Diseases
KDIGO = Kidney Disease Improving Global Outcomes
KDOQI = Kidney Disease Outcomes Quality Initiative
KDQOL-PFD = Kidney Disease Quality of Life physical function domain
MA = metabolic acidosis
MOA = mechanism of action
NH3 = ammonia
QoL = quality of life
RAAS = renin-angiotensin-aldosterone system
RCT = randomized controlled trial
RTA = renal tubular acidosis
SGLT2 = sodium glucose cotransporter-2
TRC101 = veverimer

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