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CME / ABIM MOC

Stroke Prevention in Atrial Fibrillation: Latest Guidelines and Recommendations

  • Authors: Christian T. Ruff, MD, MPH; Craig I. Coleman, PharmD; Peter Rossing, MD, DMSc
  • CME / ABIM MOC Released: 5/29/2020
  • THIS ACTIVITY HAS EXPIRED FOR CREDIT
  • Valid for credit through: 5/29/2021, 11:59 PM EST
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Target Audience and Goal Statement

This activity is intended for cardiologists, primary care physicians, and neurologists.

The goal of this activity is to provide the latest information on the use of non-vitamin K antagonist oral anticoagulants (NOACs) in atrial fibrillation (AF), especially regarding the advantages of using NOACs in patients with reduced renal function.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Clinical data showing the effect of NOACs on renal function preservation in the setting of AF
    • Differences among NOACs with respect to dosing in patients with AF and renal impairment 
  • Have increased competence regarding
    • Tailoring treatment plans for patients with AF


Disclosures

As an organization accredited by the ACCME, Medscape, LLC, requires everyone who is in a position to control the content of an education activity to disclose all relevant financial relationships with any commercial interest. The ACCME defines "relevant financial relationships" as financial relationships in any amount, occurring within the past 12 months, including financial relationships of a spouse or life partner, that could create a conflict of interest.

Medscape, LLC, encourages Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration, at first mention and where appropriate in the content.


Faculty

  • Christan T. Ruff, MD, MPH

    Director of General Cardiology
    Cardiovascular Division
    Brigham and Women's Hospital

    Investigator, TIMI Study Group

    Assistant Professor of Medicine
    Harvard Medical School
    Boston, Massachusetts, United States

    Disclosures

    Disclosure: Christian T. Ruff, MD, MPH, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Anthos; Bayer; Bristol Myers Squibb; Boehringer Ingelheim; Daiichi Sankyo; Janssen; MedImmune; Pfizer; Portola
    Received grants for clinical research from: Boehringer Ingelheim; Daiichi Sankyo; MedImmune; NIH

  • Craig I. Coleman, PharmD

    Professor of Pharmacy Practice
    University of Connecticut School of Pharmacy
    Director of UCONN/Hartford Hospital Evidence Based Practice Center
    Hartford, Connecticut, United States

    Disclosures

    Disclosure: Craig I. Coleman, PharmD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Bayer AG; Janssen; Portola Pharmaceuticals
    Received grants for clinical research from: Bayer AG; Janssen; Portola Pharmaceuticals

  • Peter Rossing, MD, DMSc

    Head of Complications Research
    Steno Diabetes Center Copenhagen
    Professor of the Department of Clinical Medicine
    University of Copenhagen
    Gentofte, Denmark

    Disclosures

    Disclosure: Peter Rossing, MD, DMSc, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Astellas; AstraZeneca; Bayer; Boehringer Ingelheim; Eli Lilly; Gilead; Novo Nordisk; Sanofi; Vifor
    Received grants for clinical research from: AstraZeneca; Novo Nordisk

Anticoagulation Management Steering Committee

  • Keith A.A. Fox, MBChB, FRCP, FMedSci

    Professor of Cardiology
    University of Edinburgh
    Edinburgh, United Kingdom

    Disclosures

    Disclosure: Keith A.A. Fox, MBChB, FRCP, FMedSci, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Bayer HealthCare; Janssen Pharmaceuticals; Regeneron Pharmaceuticals, Inc.; Sanofi; Verseon Corporation
    Served as a speaker or a member of a speakers bureau for: Bayer HealthCare; Janssen Pharmaceuticals; Regeneron Pharmaceuticals, Inc.; Sanofi
    Received grants for clinical research from: AstraZeneca Pharmaceuticals LP; Bayer HealthCare; Janssen Pharmaceuticals

  • A. John Camm, MD

    Professor
    St. George's University of London
    London, United Kingdom

    Disclosures

    Disclosure: A. John Camm, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Abbott Laboratories; Acesion Pharma; Bayer HealthCare; Biosense Webster, Inc.; BIOTRONIK; Boehringer Ingelheim Pharmaceuticals, Inc.; Boston Scientific; Cardiac Insight Inc.; Cardiome Pharma Corp.; Creavo Medical Technologies Ltd; Daiichi Sankyo, Inc.; GE Healthcare; GlaxoSmithKline; InCarda Therapeutics, Inc.; Medtronic, Inc.; Menarini Diagnostics; Milestone Pharmaceuticals, Inc.; OMEICOS Therapeutics GmbH; PCM Scientific; Pfizer Inc.; Radius Health, Inc.

  • Craig I. Coleman, PharmD

    As listed above

  • Alok A. Khorana, MD

    Professor of Medicine
    Cleveland Clinic Lerner College of Medicine
    Case Western Reserve University
    Sondra and Stephen Hardis Chair in Oncology Research
    Vice Chair (Clinical Services)
    Director
    GI Malignancies Program
    Taussig Cancer Institute
    Cleveland Clinic
    Cleveland, Ohio, United States

    Disclosures

    Disclosure: Alok A. Khorana, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: AngioDynamics; Bayer HealthCare; Halozyme Therapeutics; Janssen Pharmaceuticals; Pfizer Inc.; Seattle Genetics, Inc.
    Received grants for clinical research from: Amgen Inc.

  • Christian T. Ruff, MD, MPH

    As listed above

  • Peter Verhamme, MD, PhD

    Professor
    Vascular Medicine and Haemostasis Unit
    Department of Cardiovascular Medicine
    University Hospitals Leuven
    Leuven, Belgium

    Disclosures

    Disclosure: Peter Verhamme, MD, PhD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Anthos Therapeutics; Bayer; Boehringer Ingelheim; Bristol Myers Squibb; Daiichi Sankyo; Pfizer; Portola
    Served as a speaker or a member of a speakers bureau for: Bayer; Boehringer Ingelheim; Bristol Myers Squibb; Daiichi Sankyo; Pfizer; Portola
    Received grants for clinical research from: Bayer; Bristol Myers Squibb; Leo Pharma; Pfizer

Vascular Protection Steering Committee

  • Keith A.A. Fox, MBChB, FRCP, FMedSci

    As listed above

  • Victor Aboyans, MD, PhD

    Professor
    Head of Department of Cardiology
    Dupuytren University Hospital
    Limoges, France

    Disclosures

    Disclosure: Victor Aboyans, MD, PhD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Bayer AG
    Served as a speaker or a member of a speakers bureau for: Bayer AG; Boehringer Ingelheim Pharmaceuticals, Inc.; Novartis Pharmaceuticals Corporation; Pfizer Inc.

  • Deepak L. Bhatt, MD, MPH

    Professor of Medicine
    Harvard Medical School
    Executive Director of Interventional Cardiovascular Programs
    Brigham and Women's Hospital Heart & Vascular Center
    Boston, Massachusetts, United States

    Disclosures

    Disclosure: Deepak L. Bhatt, MD, MPH, has disclosed the following relevant financial relationships:
    Received grants for clinical research from: Abbott Laboratories; Amarin Corporation plc; Amgen Inc.; AstraZeneca Pharmaceuticals LP; Bayer HealthCare; Boehringer Ingelheim Pharmaceuticals, Inc.; Bristol-Myers Squibb Company; Chiesi Pharmaceuticals, Inc.; Eisai Inc.; Ethicon, Inc.; Forest Laboratories, Inc.; Ironwood Pharmaceuticals, Inc.; Ischemix, Inc.; Lilly; Medtronic, Inc.; Pfizer Inc.; PhaseBio Pharmaceuticals, Inc.; Regeneron Pharmaceuticals, Inc.; Roche; Sanofi; The Medicines Company

  • John W.A. Eikelboom, MBBS, MSc

    Professor
    McMaster University
    Hamilton, Ontario, Canada

    Disclosures

    Disclosure: John W. Eikelboom, MBBS, MSc, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: AstraZeneca Pharmaceuticals LP; Bayer HealthCare; Boehringer Ingelheim Pharmaceuticals, Inc.; Bristol-Myers Squibb Company; Daiichi Sankyo, Inc.; Eli Lilly; GlaxoSmithKline; Janssen Pharmaceuticals, Inc.; Pfizer Inc.; Sanofi
    Received grants for clinical research from: AstraZeneca Pharmaceuticals LP; Bayer HealthCare; Boehringer Ingelheim Pharmaceuticals, Inc.; Bristol-Myers Squibb Company; GlaxoSmithKline; Janssen Pharmaceuticals, Inc.; Pfizer Inc.; Sanofi

  • Manesh R. Patel, MD

    Professor of Medicine
    Duke University Medical Center
    Durham, North Carolina, United States

    Disclosures

    Disclosure: Manesh R. Patel, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: AstraZeneca Pharmaceuticals LP; Bayer HealthCare; Janssen Pharmaceuticals
    Received grants for clinical research from: AstraZeneca Pharmaceuticals LP; Bayer HealthCare; Janssen Pharmaceuticals; Procyrion Inc.

  • Robert C. Welsh, MD, FRCPC

    Professor of Medicine
    University of Alberta in Edmonton
    Director of Cardiac Catheterization and Interventional Cardiology
    Mazankowski Alberta Heart Institute
    Edmonton, Alberta, Canada

    Disclosures

    Disclosure: Robert C. Welsh, MD, FRCPC, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: AstraZeneca Pharmaceuticals LP; Bristol-Myers Squibb Company; Eli Lilly; Roche; Sanofi; Sepracor Inc.
    Received grants for clinical research from: AstraZeneca Pharmaceuticals LP; Boehringer Ingelheim Pharmaceuticals, Inc.; Eli Lilly; Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Portola Pharmaceuticals, Inc.; Regado Biosciences; Roche; Sanofi

Editors

  • Caroline M. Padbury, B.Pharm

    Senior Medical Education Director, Medscape, LLC

    Disclosures

    Disclosure: Caroline M. Padbury, B.Pharm, has disclosed no relevant financial relationships.

  • Asha P. Gupta, PharmD, RPh

    Senior Scientific Content Manager, Medscape, LLC

    Disclosures

    Disclosure: Asha P. Gupta, PharmD, RPh has disclosed no relevant financial relationships.

CME Reviewer

  • Esther Nyarko, PharmD

    Associate Director, Accreditation and Compliance, Medscape, LLC

    Disclosures

    Disclosure: Esther Nyarko, PharmD, has disclosed no relevant financial relationships.

Medscape, LLC staff have disclosed that they have no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has disclosed the following relevant financial relationships:

Served as an advisor or consultant for: Abbott Laboratories


Accreditation Statements

Medscape

Interprofessional Continuing Education

In support of improving patient care, Medscape, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.50 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

    Contact This Provider

For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]


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There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 75% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read the target audience, learning objectives, and author disclosures.
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CME / ABIM MOC

Stroke Prevention in Atrial Fibrillation: Latest Guidelines and Recommendations

Authors: Christian T. Ruff, MD, MPH; Craig I. Coleman, PharmD; Peter Rossing, MD, DMScFaculty and Disclosures
THIS ACTIVITY HAS EXPIRED FOR CREDIT

CME / ABIM MOC Released: 5/29/2020

Valid for credit through: 5/29/2021, 11:59 PM EST

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Educational Impact Challenge

The goal of this activity is to provide the latest information on the use of non-vitamin K antagonist oral anticoagulants (NOACs) in atrial fibrillation (AF), especially regarding the advantages of using NOACs in patients with reduced renal function.

Before you begin this activity, please assess your clinical knowledge by completing this brief survey. Answering these questions again after the activity will allow you to see what you learned and to compare your answers with those of your peers.

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