Caban C, Khan N, Hasbani DM, et al. Genetics of tuberous sclerosis complex: implications for clinical practice. Appl Clin Genet. 2017;10:1-8.
Tyburczy ME, Dies KA, Glass J, et al. Mosaic and intronic mutations in TSC1/TSC2 explain the majority of TSC patients with no mutation identified by conventional testing. PLoS Genet. 2015;11:e1005637.
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Hsieh DT, Whiteway SL, Rohena LO, et al. Tuberous sclerosis complex: five new things. Neurol Clin Pract. 2016;6:339-347.
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Zöllner JP, Franz DN, Hertzberg C, et al. A systematic review on the burden of illness in individuals with tuberous sclerosis complex (TSC). Orphanet J Rare Dis. 2020;15:23.
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CME / ABIM MOC

Assessing Practice Patterns in the Management of Tuberous Sclerosis Complex

Authors: Elizabeth A. Thiele, MD, PhD
CME / ABIM MOC Released: 5/29/2020
THIS ACTIVITY HAS EXPIRED FOR CREDIT
Valid for credit through: 5/29/2021

Target Audience and Goal Statement

This activity is intended for neurologists, pediatricians, and primary care physicians.

The goal of this activity is to establish a baseline of clinician learner knowledge, skills, attitudes, or competence regarding the diagnosis and management patients with tuberous sclerosis complex (TSC).

Upon completion of this activity, participants will:

Have increased knowledge regarding the
- Assessment of TSC
Self-assess learning needs related to
- The management of TSC

Disclosures

As an organization accredited by the ACCME, Medscape, LLC, requires everyone who is in a position to control the content of an education activity to disclose all relevant financial relationships with any commercial interest. The ACCME defines "relevant financial relationships" as financial relationships in any amount, occurring within the past 12 months, including financial relationships of a spouse or life partner, that could create a conflict of interest.

Medscape, LLC, encourages Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration, at first mention and where appropriate in the content.

Faculty

Elizabeth A. Thiele, MD, PhD

Professor of Neurology
Harvard Medical School
Director
Pediatric Epilepsy Program
Director
Carol and James Herscot Center for Tuberous Sclerosis Complex
Massachusetts General Hospital
Boston, Massachusetts

Disclosures

Disclosure: Elizabeth A. Thiele, MD, PhD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Aquestive; Biocodex; GW Pharma; Thorlabs; UCB Pharma; West Therapeutics; Zogenix
Received grants for clinical research from: GW Pharma; Zogenix

Steering Committee

Elizabeth A. Thiele, MD, PhD

As seen Above

Michelle H. Cameron, MD, PT, MCR

Associate Professor of Neurology
Oregon Health & Sciences University
Portland, Oregon

Disclosures

Disclosure: Michelle Hannah Cameron, MD, PT, MCR, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Adamas Pharmaceuticals; Greenwich Biosciences, Inc.

Tyler E. Gaston, MD

Assistant Professor of Neurology
University of Alabama
Birmingham, Alabama

Disclosures

Disclosure: Tyler E. Gaston, MD, has disclosed no relevant financial relationships.

Barry E. Gidal, PharmD

Professor of Pharmacy
Professor of Neurology
University of Wisconsin
Madison, Wisconsin

Disclosures

Disclosure: Barry E. Gidal, PharmD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Aquestive; Eisai; Greenwich Biosciences Inc.; Neurelis; Sunovion
Served as a speaker or a member of a speakers bureau for: Eisai; Greenwich Biosciences Inc.; Sunovion
Received grants for clinical research from: UCB

Patricia McGoldrick, NP, MPA, MSN

Co-Director of Pediatric Epilepsy and EMU
Boston Children's Health Physicians - Westchester and Connecticut
Maria Fareri Children's Hospital
Valhalla, New York

Disclosures

Disclosure: Patricia McGoldrick, NP, MPA, MSN, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Eisai; Greenwich Biosciences Inc.; Lundbeck; Mallinckrodt; Neuropace; Sunovion; Supernus
Served as a speaker or a member of a speakers bureau for: Eisai; Greenwich Biosciences Inc.; Lundbeck; Mallinckrodt; Sunovion; Supernus
Received grants for clinical research from: Lundbeck

Anup Patel, MD

Associate Professor of Clinical Pediatrics and Neurology
The Ohio State University College of Medicine
Section Chief
Pediatric Neurology
Nationwide Children's
Columbus, Ohio

Disclosures

Disclosure: Anup Patel, MD, has disclosed the following relevant financial relationships:
Received grants for clinical research from: GW Pharma; Stoke

Editors

Catherine Friederich Murray, MNLM

Medical Education Director, Medscape, LLC

Disclosures

Disclosure: Catherine Friederich Murray, MNLM, has disclosed no relevant financial relationships.

Aisha Cobbs, PhD

Medical Writer, Medscape, LLC

Disclosures

Disclosure: Aisha Cobbs, PhD, has disclosed no relevant financial relationships.

CME Reviewer

Esther Nyarko, PharmD

Associate Director, Accreditation and Compliance, Medscape, LLC

Disclosures

Disclosure: Esther Nyarko, PharmD, has disclosed no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has disclosed no relevant financial relationships.

Medscape, LLC staff have disclosed that they have no relevant financial relationships.

Accreditation Statements

In support of improving patient care, Medscape, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

For Physicians

Medscape, LLC designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.25 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

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This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 70% on the post-test.

Follow these steps to earn CME/CE credit*:

Read the target audience, learning objectives, and author disclosures.
Study the educational content online or printed out.
Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period you can print out the tally as well as the certificates from the CME/CE Tracker.

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From Medscape Education

CME / ABIM MOC

Assessing Practice Patterns in the Management of Tuberous Sclerosis Complex

Authors: Elizabeth A. Thiele, MD, PhDFaculty and Disclosures

THIS ACTIVITY HAS EXPIRED FOR CREDIT

CME / ABIM MOC Released: 5/29/2020

Valid for credit through: 5/29/2021

processing....

The goals of continuing medical education (CME) and professional development are to acquire and retain knowledge that will enhance clinical practice and improve patient outcomes. The following self-assessment survey is offered for CME credit and is designed to test your current knowledge and skills related to the diagnosis and management of tuberous sclerosis complex (TSC).

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CME / ABIM MOC Information

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Disclaimer

The educational activity presented above may involve simulated, case-based scenarios. The patients depicted in these scenarios are fictitious and no association with any actual patient, whether living or deceased, is intended or should be inferred. The material presented here does not necessarily reflect the views of Medscape, LLC, or any individuals or commercial entities that support companies that support educational programming on medscape.org. These materials may include discussion of therapeutic products that have not been approved by the US Food and Drug Administration, off-label uses of approved products, or data that were presented in abstract form. These data should be considered preliminary until published in a peer-reviewed journal. Readers should verify all information and data before treating patients or employing any therapies described in this or any educational activity. A qualified healthcare professional should be consulted before using any therapeutic product discussed herein.

References

Faculty and Disclosures

Faculty

Elizabeth A. Thiele, MD, PhD

Steering Committee

Elizabeth A. Thiele, MD, PhD

Michelle H. Cameron, MD, PT, MCR

Tyler E. Gaston, MD

Barry E. Gidal, PharmD

Patricia McGoldrick, NP, MPA, MSN

Anup Patel, MD

Editors

Catherine Friederich Murray, MNLM

Aisha Cobbs, PhD

CME Reviewer

Esther Nyarko, PharmD

Peer Reviewer

CME / ABIM MOC

Assessing Practice Patterns in the Management of Tuberous Sclerosis Complex

Target Audience and Goal Statement

Disclosures

Faculty

Elizabeth A. Thiele, MD, PhD

Steering Committee

Elizabeth A. Thiele, MD, PhD

Michelle H. Cameron, MD, PT, MCR

Tyler E. Gaston, MD

Barry E. Gidal, PharmD

Patricia McGoldrick, NP, MPA, MSN

Anup Patel, MD

Editors

Catherine Friederich Murray, MNLM

Aisha Cobbs, PhD

CME Reviewer

Esther Nyarko, PharmD

Peer Reviewer

Accreditation Statements

For Physicians

Instructions for Participation and Credit

Assessing Practice Patterns in the Management of Tuberous Sclerosis Complex