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CME / ABIM MOC

Factor Xa Inhibitors in CAD/PAD: Where Are We Today?

  • Authors: John W.A. Eikelboom, MBBS, MSc; Jeffrey I. Weitz, MD, FRCPC; Christoph Bode, MD
  • CME / ABIM MOC Released: 5/18/2020
  • THIS ACTIVITY HAS EXPIRED FOR CREDIT
  • Valid for credit through: 5/18/2021, 11:59 PM EST
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Target Audience and Goal Statement

This activity is intended for cardiologist, primary physicians, and surgeons.

The goal of this activity is to provide the latest information on the use of factor Xa inhibitors in preventing further cardiovascular events in patients with CAD and/or PAD.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Current clinical guidelines for treatment of coronary artery disease/peripheral artery disease (CAD/PAD)
    • Data supporting the use of antithrombotic therapy for patients with CAD/PAD
  • Have greater competence related to
    • Patient selection for factor Xa inhibitor therapy in the setting of stable CAD/PAD


Disclosures

As an organization accredited by the ACCME, Medscape, LLC, requires everyone who is in a position to control the content of an education activity to disclose all relevant financial relationships with any commercial interest. The ACCME defines "relevant financial relationships" as financial relationships in any amount, occurring within the past 12 months, including financial relationships of a spouse or life partner, that could create a conflict of interest.

Medscape, LLC, encourages Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration, at first mention and where appropriate in the content.


Authors

  • John W. A. Eikelboom, MBBS, MSc

    Professor of Medicine
    McMaster University
    Hamilton, Ontario, Canada

    Disclosures

    Disclosure: John W. A. Eikelboom, MBBS, MSc, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: AstraZeneca Pharmaceuticals LP; Bayer HealthCare; Boehringer Ingelheim Pharmaceuticals, Inc.; Bristol-Myers Squibb Company; Daiichi Sankyo, Inc.; Eli Lilly; GlaxoSmithKline; Janssen Pharmaceuticals, Inc.; Pfizer Inc.; Sanofi; SERVIER
    Received grants for clinical research from: AstraZeneca Pharmaceuticals LP; Bayer HealthCare; Boehringer Ingelheim Pharmaceuticals, Inc.; Bristol-Myers Squibb Company; GlaxoSmithKline; Janssen Pharmaceuticals, Inc.; Pfizer Inc.; Sanofi

  • Jeffrey I. Weitz, MD, FRCPC

    Professor of Medicine and Biochemistry
    McMaster University
    Hamilton, Ontario, Canada

    Disclosures

    Disclosure: Jeffery I. Weitz, MD, FRCPC, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Anthos; Bayer; Boehringer Ingelheim; Bristol Myers Squibb; Daiichi Sankyo, Inc; Ionis; Janssen; Merck; Novartis; Pfizer; Portola; Tetherex

  • Christoph Bode, MD

    Professor of Cardiology and Angiology
    Heart Center Freiburg University
    Freiburg, Germany

    Disclosures

    Disclosure: Christoph Bode, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Bayer; Bristol Myers Squibb; Daiichi Sankyo Inc
    Served as a speaker or a member of a speakers bureau for: Bayer; Bristol Myers Squibb; Daiichi Sankyo, Inc.

Anticoagulation Management Steering Committee

  • Keith A.A. Fox, MBChB, FRCP, FMedSci

    Professor of Cardiology
    University of Edinburgh
    Edinburgh, United Kingdom

    Disclosures

    Disclosure: Keith A.A. Fox, MBChB, FRCP, FMedSci, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Bayer HealthCare; Janssen Pharmaceuticals; Regeneron Pharmaceuticals, Inc.; Sanofi; Verseon Corporation
    Served as a speaker or a member of a speakers bureau for: Bayer HealthCare; Janssen Pharmaceuticals; Regeneron Pharmaceuticals, Inc.; Sanofi
    Received grants for clinical research from: AstraZeneca Pharmaceuticals LP; Bayer HealthCare; Janssen Pharmaceuticals

  • A. John Camm, MD

    Professor
    St. George's University of London
    London, United Kingdom

    Disclosures

    Disclosure: A. John Camm, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Abbott Laboratories; Acesion Pharma; Bayer HealthCare; Biosense Webster, Inc.; BIOTRONIK; Boston Scientific; Boehringer Ingelheim Pharmaceuticals, Inc.; Cardiac Insight Inc.; Cardiome Pharma Corp.; Creavo Medical Technologies Ltd; Daiichi Sankyo, Inc.; GE Healthcare; GlaxoSmithKline; InCarda Therapeutics, Inc.; Medtronic, Inc.; Menarini Diagnostics; Milestone Pharmaceuticals, Inc.; OMEICOS Therapeutics GmbH; PCM Scientific; Pfizer Inc.; Radius Health, Inc.

  • Craig I. Coleman, PharmD

    Professor
    University of Connecticut
    Storrs, Connecticut, United States

    Disclosures

    Disclosure: Craig I. Coleman, PharmD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Bayer AG; Boehringer Ingelheim Pharmaceuticals, Inc.; Janssen Pharmaceuticals, Inc.
    Served as a speaker or a member of a speakers bureau for: Bayer AG; Janssen Pharmaceuticals, Inc.
    Received grants for clinical research from: Bayer AG; Janssen Pharmaceuticals, Inc.; Zoll Medical Corporation

  • Alok A. Khorana, MD

    Professor of Medicine
    Cleveland Clinic Lerner College of Medicine
    Case Western Reserve University
    Sondra and Stephen Hardis Chair in Oncology Research
    Vice Chair (Clinical Services)
    Director
    GI Malignancies Program
    Taussig Cancer Institute
    Cleveland Clinic
    Cleveland, Ohio, United States

    Disclosures

    Disclosure: Alok A. Khorana, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: AngioDynamics; Bayer HealthCare; Halozyme Therapeutics; Janssen Pharmaceuticals; Pfizer Inc.; Seattle Genetics, Inc.
    Received grants for clinical research from: Amgen Inc.

  • Christian T. Ruff, MD, MPH

    Assistant Professor of Medicine
    Harvard Medical School
    Director of General Cardiology
    Cardiovascular Division
    TIMI Study Group
    Brigham and Women's Hospital
    Boston, Massachusetts, United States

    Disclosures

    Disclosure: Christian T. Ruff, MD, MPH, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Bayer HealthCare; Boehringer Ingelheim Pharmaceuticals, Inc.; Bristol Myers Squibb Company; Daiichi Sankyo, Inc.; Janssen Pharmaceuticals; Pfizer Inc.; Portola Pharmaceuticals
    Received grants for clinical research from: Boehringer Ingelheim Pharmaceuticals, Inc.; Daiichi Sankyo, Inc.; MedImmune Inc.

  • Peter Verhamme, MD, PhD

    Professor
    Vascular Medicine and Haemostasis Unit
    Department of Cardiovascular Medicine
    University Hospitals Leuven
    Leuven, Belgium

    Disclosures

    Disclosure: Peter Verhamme, MD, PhD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Anthos Therapeutics; Bayer; Boehringer Ingelheim; Bristol Myers Squibb; Daiichi Sankyo; Pfizer; Portola
    Served as a speaker or a member of a speakers bureau for: Bayer; Boehringer Ingelheim; Bristol Myers Squibb; Daiichi Sankyo; Pfizer; Portola
    Received grants for clinical research from: Bayer; Bristol Myers Squibb; Leo Pharma; Pfizer

Vascular Protection Steering Committee

  • Keith A.A. Fox, MBChB, FRCP, FMedSci

    As listed above

  • Victor Aboyans, MD, PhD

    Professor
    Head of Department of Cardiology
    Dupuytren University Hospital
    Limoges, France

    Disclosures

    Disclosure: Victor Aboyans, MD, PhD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Bayer AG
    Served as a speaker or a member of a speakers bureau for: Bayer AG; Boehringer Ingelheim Pharmaceuticals, Inc.; Novartis Pharmaceuticals Corporation; Pfizer Inc.

  • Deepak L. Bhatt, MD, MPH

    Professor of Medicine
    Harvard Medical School
    Executive Director of Interventional Cardiovascular Programs
    Brigham and Women's Hospital Heart & Vascular Center
    Boston, Massachusetts, United States

    Disclosures

    Disclosure: Deepak L. Bhatt, MD, MPH, has disclosed the following relevant financial relationships:
    Received grants for clinical research from: Abbott Laboratories; Amarin Corporation plc; Amgen Inc.; AstraZeneca Pharmaceuticals LP; Bayer HealthCare; Boehringer Ingelheim Pharmaceuticals, Inc.; Bristol-Myers Squibb Company; Chiesi Pharmaceuticals, Inc.; Eisai Inc.; Ethicon, Inc.; Forest Laboratories, Inc.; Ironwood Pharmaceuticals, Inc.; Ischemix, Inc.; Lilly; Medtronic, Inc.; Pfizer Inc.; PhaseBio Pharmaceuticals, Inc.; Regeneron Pharmaceuticals, Inc.; Roche; Sanofi; The Medicines Company

  • John W.A. Eikelboom, MBBS, MSc

    As listed above

  • Manesh R. Patel, MD

    Professor of Medicine
    Duke University Medical Center
    Durham, North Carolina, United States

    Disclosures

    Disclosure: Manesh R. Patel, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: AstraZeneca Pharmaceuticals LP; Bayer HealthCare; Janssen Pharmaceuticals
    Received grants for clinical research from: AstraZeneca Pharmaceuticals LP; Bayer HealthCare; Janssen Pharmaceuticals; Procyrion Inc.

  • Robert C. Welsh, MD, FRCPC

    Professor of Medicine
    University of Alberta in Edmonton
    Director of Cardiac Catheterization and Interventional Cardiology
    Mazankowski Alberta Heart Institute
    Edmonton, Alberta, Canada

    Disclosures

    Disclosure: Robert C. Welsh, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: AstraZeneca Pharmaceuticals LP; Bristol Myers Squibb Company; Eli Lilly; Roche; Sanofi; Sepracor Inc.
    Received grants for clinical research from: AstraZeneca Pharmaceuticals LP; Boehringer Ingelheim Pharmaceuticals, Inc.; Eli Lilly; Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Portola Pharmaceuticals, Inc.; Regado Biosciences; Roche; Sanofi

Editors

  • Caroline M. Padbury, B.Pharm

    Senior Medical Education Director, Medscape, LLC

    Disclosures

    Disclosure: Caroline M. Padbury, B.Pharm, has disclosed no relevant financial relationships.

  • Asha P. Gupta, PharmD, RPh

    Senior Scientific Content Manager, Medscape, LLC

    Disclosures

    Disclosure: Asha P. Gupta, PharmD, RPh has disclosed no relevant financial relationships.

CME Reviewer

  • Robert Morris, PharmD

    Associate Director, Accreditation and Compliance, Medscape, LLC

    Disclosures

    Disclosure: Robert Morris, PharmD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: ViiV Healthcare
    Owns stock, stock options, or bonds from: GlaxoSmithKline

Medscape, LLC staff have disclosed that they have no relevant financial relationships.

Peer Reviewer
This activity has been peer reviewed and the reviewer has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Abbott Laboratories.


Accreditation Statements

Medscape

Interprofessional Continuing Education

In support of improving patient care, Medscape, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.50 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

    Contact This Provider

For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]


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This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 75% on the post-test.

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CME / ABIM MOC

Factor Xa Inhibitors in CAD/PAD: Where Are We Today?

Authors: John W.A. Eikelboom, MBBS, MSc; Jeffrey I. Weitz, MD, FRCPC; Christoph Bode, MDFaculty and Disclosures
THIS ACTIVITY HAS EXPIRED FOR CREDIT

CME / ABIM MOC Released: 5/18/2020

Valid for credit through: 5/18/2021, 11:59 PM EST

processing....

Abbreviations

ACEI = angiotensin-converting enzyme inhibitor
ACS = acute coronary syndrome
ALI = acute limb ischemia 
ARB = angiotensin receptor blocker
ARR = absolute risk reduction
ASCVD = atherosclerotic cardiovascular disease
BARC = Bleeding Academic Research Consortium
CAD = coronary artery disease
CCS = chronic coronary syndrome
CHD = coronary heart disease
CLTI = chronic limb-threatening ischemia
CV = cardiovascular
CVD = cardiovascular disease
DAPT = dual antiplatelet therapy
DM = diabetes mellitus
DPI = dual pathway inhibition
DSMB = Data and Safety Monitoring Board
EASD = European Association for the Study of Diabetes
eGFR = estimated glomerular filtration rate
ESC = European Society of Cardiology
ESVM = European Society of Vascular Medicine
f/u = follow-up
GI = gastrointestinal tract
HTN = hypertension
ICH = intracranial hemorrhage
ISTH = International Society on Thrombosis and Haemostasis
KM = Kaplan-Meier
MACE = major adverse cardiac events
MACLE = major adverse cardiovascular and limb event
MALE = major adverse limb events
MI = myocardial infarction
NNH = number needed to harm
NNT = number needed to treat
NR = not reported
NSAID = nonsteroidal anti-inflammatory drug
PAD = peripheral artery disease
PAR = protease-activated receptor
PCI = percutaneous coronary intervention
PPI = proton pump inhibitor
RBC = red blood cell
RRR = relative risk reduction
TIA = transient ischemic attack
TIMI = Thrombolysis in Myocardial Infarction
VTE = venous thromboembolism

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