Tuesday, November 28, 2023
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Clinical Associate Professor
Stanford University
Stanford, California
Associate Clinical CME Director, Medscape, LLC
This activity has been peer reviewed and the reviewer has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Boehringer Ingelheim Pharmaceuticals, Inc.; Ipsen Pharma
This activity is intended for oncology specialists, pulmonologists, pathologists, and nurses.
The goal of this activity is to educate clinicians treating patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) on optimal strategies for diagnosis and management of leptomeningeal carcinomatosis (LMC).
Upon completion of this activity, participants will:
As an organization accredited by the ACCME, Medscape, LLC, requires everyone who is in a position to control the content of an education activity to disclose all relevant financial relationships with any commercial interest. The ACCME defines "relevant financial relationships" as financial relationships in any amount, occurring within the past 12 months, including financial relationships of a spouse or life partner, that could create a conflict of interest.
Medscape, LLC, encourages Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration, at first mention and where appropriate in the content.
Clinical Associate Professor
Stanford University
Stanford, California
Associate Clinical CME Director, Medscape, LLC
This activity has been peer reviewed and the reviewer has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Boehringer Ingelheim Pharmaceuticals, Inc.; Ipsen Pharma
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Awarded 1.0 contact hour(s) of continuing nursing education for RNs and APNs; 1.0 contact hours are in the area of pharmacology.
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CME / ABIM MOC / CE Released: 6/21/2019
Valid for credit through: 6/21/2020, 11:59 PM EST
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The following cases are modeled on the interactive grand rounds approach. The questions within the activity are designed to test your current knowledge. After each question, you will be able to see whether you answered correctly and read evidence-based information that supports the most appropriate answer choice. The questions are designed to challenge you; you will not be penalized for answering the questions incorrectly. At the end of the activity, there will be a short post-test assessment based on the material presented.
The goal of this activity is to educate clinicians treating patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) on optimal strategies for diagnosis and management of leptomeningeal carcinomatosis (LMC).
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Steven is a 62-year-old never smoker who was diagnosed with stage IV adenocarcinoma of the lung. Computed tomography (CT) showed a right upper lobe mass and bone metastases with no central nervous system (CNS) metastases. Genotyping showed epidermal growth factor receptor (EGFR) exon 21 L858R mutation. He received first-line osimertinib (80 mg daily) and tolerated therapy well, demonstrating a partial response. Six months later, he comes in for a follow-up visit and is complaining of progressively worse headaches each morning and occasional unexplained nausea and vomiting. You suspect he has developed CNS metastases or leptomeningeal carcinomatosis (LMC).
