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Moderator

Mathew Maurer, MD

Arnold and Arlene Goldstein Professor of Cardiology
Department of Medicine Cardiology
Columbia University Medical Center
New York, New York

Disclosures

Disclosure: Mathew Maurer, MD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Akcea Therapeutics; Amylon Therapeutics; Ionis Pharmaceutcials; Pfizer Inc.

Panelists

Jose Nativi-Nicolau, MD

Assistant Professor
University of Utah
Salt Lake City, Utah

Disclosures

Disclosure: Jose Nativi-Nicolau, MD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Akcea Therapeutics; Alnylam Pharmaceuticals, Inc.; Pfizer Inc.
Received grants for clinical research from: Akcea Therapeutics; Eidos Therapeutics; Pfizer Inc.

Ronald M. Witteles, MD

Associate Professor of Cardiovascular Medicine
Co-Director
Stanford Amyloid Center
Stanford University School of Medicine
Stanford, California

Disclosures

Disclosure: Ronald M. Witteles, MD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Alnylam Pharmaceuticals, Inc.; Pfizer Inc.
Received grants for clinical research from: Eidos Therapeutics; Pfizer Inc.

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Joy P. Marko, MS, APN-C, CCMEP

Scientific Director, Medscape, LLC

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Kalanethee Paul-Pletzer, PhD

Scientific Director, Medscape, LLC

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Disclosure: Kalanethee Paul-Pletzer, PhD, has disclosed no relevant financial relationships.

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Amy Bernard, MS, BSN, RN-BC, CHCP

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This activity has been peer reviewed and the reviewer has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Abbott Laboratories; Medtronic, Inc.

CME / ABIM MOC / CE

Amyloidosis in Cardiology Practice: A Race Against Time

Authors: Mathew Maurer, MD; Jose Nativi-Nicolau, MD; Ronald M. Witteles, MD
CME / ABIM MOC / CE Released: 3/28/2019
THIS ACTIVITY HAS EXPIRED FOR CREDIT
Valid for credit through: 3/28/2020

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Target Audience and Goal Statement

This activity is intended for cardiologists, neurologists, hematology and oncology specialists, and nurses.

The goal of this activity is to improve the recognition, diagnosis, and management of cardiac amyloidosis.

Upon completion of this activity, participants will:

Have increased knowledge regarding the
- Clinical signs and symptoms of amyloidosis
- Latest clinical data on treatment of hereditary transthyretin-related amyloidosis
Have greater competence related to
- Patient assessment to improve early diagnosis of amyloidosis

Disclosures

Moderator

Mathew Maurer, MD

Arnold and Arlene Goldstein Professor of Cardiology
Department of Medicine Cardiology
Columbia University Medical Center
New York, New York

Disclosures

Disclosure: Mathew Maurer, MD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Akcea Therapeutics; Amylon Therapeutics; Ionis Pharmaceutcials; Pfizer Inc.

Panelists

Jose Nativi-Nicolau, MD

Assistant Professor
University of Utah
Salt Lake City, Utah

Disclosures

Disclosure: Jose Nativi-Nicolau, MD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Akcea Therapeutics; Alnylam Pharmaceuticals, Inc.; Pfizer Inc.
Received grants for clinical research from: Akcea Therapeutics; Eidos Therapeutics; Pfizer Inc.

Ronald M. Witteles, MD

Associate Professor of Cardiovascular Medicine
Co-Director
Stanford Amyloid Center
Stanford University School of Medicine
Stanford, California

Disclosures

Disclosure: Ronald M. Witteles, MD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Alnylam Pharmaceuticals, Inc.; Pfizer Inc.
Received grants for clinical research from: Eidos Therapeutics; Pfizer Inc.

Editors

Joy P. Marko, MS, APN-C, CCMEP

Scientific Director, Medscape, LLC

Disclosures

Disclosure: Joy P. Marko, MS, APN-C, CCMEP, has disclosed no relevant financial relationships.

Kalanethee Paul-Pletzer, PhD

Scientific Director, Medscape, LLC

Disclosures

Disclosure: Kalanethee Paul-Pletzer, PhD, has disclosed no relevant financial relationships.

Nurse Planner

Amy Bernard, MS, BSN, RN-BC, CHCP

Lead Nurse Planner, Medscape, LLC

Disclosures

Disclosure: Amy Bernard, MS, BSN, RN-BC, CHCP, has disclosed no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Abbott Laboratories; Medtronic, Inc.

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From Medscape Education Cardiology

CME / ABIM MOC / CE

Amyloidosis in Cardiology Practice: A Race Against Time

Authors: Mathew Maurer, MD; Jose Nativi-Nicolau, MD; Ronald M. Witteles, MDFaculty and Disclosures

THIS ACTIVITY HAS EXPIRED FOR CREDIT

CME / ABIM MOC / CE Released: 3/28/2019

Valid for credit through: 3/28/2020

processing....

Abbreviations

6MWT = 6-minute walk-test
AA = secondary amyloidosis
AE = adverse event
AL amyloidosis = immunoglobulin light-chain amyloidosis
AL amyloid = immunoglobulin light-chain amyloid
AS = aortic stenosis
ATTR = transthyretin-related amyloidosis
ATTRmt = transthyretin-mutant amyloidosis
ATTRwt = transthyretin-wild type amyloidosis
AV = atrioventricular
BNP = brain natriuretic peptide
CA = cardiac amyloidosis
CM = cardiomyopathy
Cr = creatinine
CT = carpal tunnel
cTnT = cardiac troponin T
CV = cardiovascular
DPD = 3,3-diphosphono-1,2-propanodicarboxylic acid
ECG = electrocardiographic; electrocardiogram
EF = ejection fraction
FLC = free light chain
FLC-diff = difference between involved and uninvolved light chain
hATTR = hereditary transthyretin-related amyloidosis
H:CL = heart:contralateral
HCM = hypertrophic cardiomyopathy
HDP = ^99mTc-labeled hydroxymethylene diphosphonate
HF = heart failure
HFpEF = heart failure with preserved ejection fraction
HTN = hypertension
IF = immunofluorescence
KCCQ-OS = Kansas City Cardiomyopathy Questionnaire–Overall Summary
LGE = late gadolinium enhancement
LV = left ventricular
LVEF = left ventricular ejection fraction
LVH = left ventricular hypertrophy
Mo = month
MRI = magnetic resonance imaging
MWT = maximal wall thickness
NIS = Neuropathy Impairment Score
NNT = number needed to treat
NSAID = nonsteroidal anti-inflammatory drug
NT-proBNP = N-terminal pro-B-type natriuretic peptide
NYHA = New York Heart Association
PYP = pyrophosphate
RNAi = RNA interference
SPIE = serum protein immunoelectrophoresis
TAVR = transcatheter aortic valve replacement
THOAS = Transthyretin Amyloid Outcome Survey
TTR = transthyretin
UPIE = urine protein immunoelectrophoresis

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References

Faculty and Disclosures

Moderator

Mathew Maurer, MD

Panelists

Jose Nativi-Nicolau, MD

Ronald M. Witteles, MD

Editors

Joy P. Marko, MS, APN-C, CCMEP

Kalanethee Paul-Pletzer, PhD

Nurse Planner

Amy Bernard, MS, BSN, RN-BC, CHCP

Peer Reviewer

CME / ABIM MOC / CE

Amyloidosis in Cardiology Practice: A Race Against Time

Target Audience and Goal Statement

Disclosures

Moderator

Mathew Maurer, MD

Panelists

Jose Nativi-Nicolau, MD

Ronald M. Witteles, MD

Editors

Joy P. Marko, MS, APN-C, CCMEP

Kalanethee Paul-Pletzer, PhD

Nurse Planner

Amy Bernard, MS, BSN, RN-BC, CHCP

Peer Reviewer

Accreditation Statements

For Physicians

For Nurses

Instructions for Participation and Credit

Amyloidosis in Cardiology Practice: A Race Against Time

Abbreviations