Maurer MS, Elliott P, Comenzo R, et al. Addressing common questions encountered in the diagnosis and management of cardiac amyloidosis. Circulation. 2017;135:1357-1377.
Bokhari S, Castaño A, Pozniakoff T, et al. (99m)Tc-pyrophosphate scintigraphy for differentiating light-chain cardiac amyloidosis from the transthyretin-related familial and senile cardiac amyloidoses. Circ Cardiovasc Imaging. 2013;6:195-201.
Maurer MS, Hanna M, Grogan M, et al. Genotype and Phenotype of Transthyretin Cardiac Amyloidosis: THAOS (Transthyretin Amyloid Outcome Survey). J Am Coll Cardiol. 2016;68:161-172.
Mohamed-Salem L, Santos-Mateo JJ, Sanchez-Serna J, et al. Prevalence of wild type ATTR assessed as myocardial uptake in bone scan in the elderly population. Int J Cardiol. 2018;270:192-196.
González-López E, Gallego-Delgado M, Guzzo-Merello G, et al. Wild-type transthyretin amyloidosis as a cause of heart failure with preserved ejection fraction. Eur Heart J. 2015;36:2585-2594.
Castaño A, Narotsky DL, Hamid N, et al. Unveiling transthyretin cardiac amyloidosis and its predictors among elderly patients with severe aortic stenosis undergoing transcatheter aortic valve replacement. Eur Heart J. 2017;38:2879-2887.
Dungu JN, Papadopoulou SA, Wykes K, et al. Afro-Caribbean heart failure in the United Kingdom: cause, outcomes, and ATTR V122I cardiac amyloidosis. Circ Heart Fail. 2016;9.pii:e003352.
Nativi-Nicolau J, Maurer MS. Amyloidosis cardiomyopathy: update in the diagnosis and treatment of the most common types. Curr Opin Cardiol. 2018;33:571-579.
Cyrille NB, Goldsmith J, Alvarez J, et al. Prevalence and prognostic significance of low QRS voltage among the three main types of cardiac amyloidosis. Am J Cardiol. 2014;114:1089-1093.
Syed IS, Glockner JF, Feng D, et al. Role of cardiac magnetic resonance imaging in the detection of cardiac amyloidosis. JACC Cardiovasc Imaging. 2010;3:155-164.
Di Nunzio D, Recupero A, de Gregorio C, et al. Echocardiographic findings in cardiac amyloidosis: inside two-dimensional, Doppler, and strain imaging. Curr Cardiol Rep. 2019;21:7.
Ng B, Connors LH, Davidoff R, et al. Senile systemic amyloidosis presenting with heart failure: a comparison with light chain-associated amyloidosis. Arch Intern Med. 2005;165:1425-1429.
Dubrey SW, Cha K, Skinner M, et al. Familial and primary (AL) cardiac amyloidosis: echocardiographically similar diseases with distinctly different clinical outcomes. Heart. 1997;78:74-82.
Kumar S, Dispenzieri A, Lacy MQ, et al. Revised prognostic staging system for light chain amyloidosis incorporating cardiac biomarkers and serum free light chain measurements. J Clin Oncol. 2012;30:989-995.
Brunjes DL, Castano A, Clemons A, et al. Transthyretin cardiac amyloidosis in older Americans. J Card Fail. 2016;22:996-1003.
Bogov B, Lubomirova M, Kiperova B. Biopsy of subcutaneous fatty tissue for diagnosis of systemic amyloidosis. Hippokratia. 2008;12:236-239.
Castano A, Haq M, Narotsky DL, et al. Multicenter study of planar technetium 99m pyrophosphate cardiac imaging: predicting survival for patients with ATTR cardiac amyloidosis. JAMA Cardiol. 2016;1:880-889.
Gillmore JD, Maurer MS, Falk RH, et al. Nonbiopsy diagnosis of cardiac transthyretin amyloidosis. Circulation. 2016;133:2404-2412.
Penchala SC, Connelly S, Wang Y, et al. AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proc Natl Acad Sci U S A. 2013;110:9992-9997.
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Moderator

Mathew Maurer, MD

Arnold and Arlene Goldstein Professor of Cardiology
Department of Medicine Cardiology
Columbia University Medical Center
New York, New York

Disclosures

Disclosure: Mathew Maurer, MD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Akcea Therapeutics; Amylon Therapeutics; Ionis Pharmaceutcials; Pfizer Inc.

Panelists

Jose Nativi-Nicolau, MD

Assistant Professor
University of Utah
Salt Lake City, Utah

Disclosures

Disclosure: Jose Nativi-Nicolau, MD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Akcea Therapeutics; Alnylam Pharmaceuticals, Inc.; Pfizer Inc.
Received grants for clinical research from: Akcea Therapeutics; Eidos Therapeutics; Pfizer Inc.

Ronald M. Witteles, MD

Associate Professor of Cardiovascular Medicine
Co-Director
Stanford Amyloid Center
Stanford University School of Medicine
Stanford, California

Disclosures

Disclosure: Ronald M. Witteles, MD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Alnylam Pharmaceuticals, Inc.; Pfizer Inc.
Received grants for clinical research from: Eidos Therapeutics; Pfizer Inc.

Editors

Joy P. Marko, MS, APN-C, CCMEP

Scientific Director, Medscape, LLC

Disclosures

Disclosure: Joy P. Marko, MS, APN-C, CCMEP, has disclosed no relevant financial relationships.

Kalanethee Paul-Pletzer, PhD

Scientific Director, Medscape, LLC

Disclosures

Disclosure: Kalanethee Paul-Pletzer, PhD, has disclosed no relevant financial relationships.

Nurse Planner

Amy Bernard, MS, BSN, RN-BC, CHCP

Lead Nurse Planner, Medscape, LLC

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Disclosure: Amy Bernard, MS, BSN, RN-BC, CHCP, has disclosed no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Abbott Laboratories; Medtronic, Inc.

CME / ABIM MOC / CE

Amyloidosis in Cardiology Practice: A Race Against Time

Authors: Mathew Maurer, MD; Jose Nativi-Nicolau, MD; Ronald M. Witteles, MD
CME / ABIM MOC / CE Released: 3/28/2019
THIS ACTIVITY HAS EXPIRED FOR CREDIT
Valid for credit through: 3/28/2020

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Target Audience and Goal Statement

This activity is intended for cardiologists, neurologists, hematology and oncology specialists, and nurses.

The goal of this activity is to improve the recognition, diagnosis, and management of cardiac amyloidosis.

Upon completion of this activity, participants will:

Have increased knowledge regarding the
- Clinical signs and symptoms of amyloidosis
- Latest clinical data on treatment of hereditary transthyretin-related amyloidosis
Have greater competence related to
- Patient assessment to improve early diagnosis of amyloidosis

Disclosures

Moderator

Mathew Maurer, MD

Arnold and Arlene Goldstein Professor of Cardiology
Department of Medicine Cardiology
Columbia University Medical Center
New York, New York

Disclosures

Disclosure: Mathew Maurer, MD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Akcea Therapeutics; Amylon Therapeutics; Ionis Pharmaceutcials; Pfizer Inc.

Panelists

Jose Nativi-Nicolau, MD

Assistant Professor
University of Utah
Salt Lake City, Utah

Disclosures

Disclosure: Jose Nativi-Nicolau, MD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Akcea Therapeutics; Alnylam Pharmaceuticals, Inc.; Pfizer Inc.
Received grants for clinical research from: Akcea Therapeutics; Eidos Therapeutics; Pfizer Inc.

Ronald M. Witteles, MD

Associate Professor of Cardiovascular Medicine
Co-Director
Stanford Amyloid Center
Stanford University School of Medicine
Stanford, California

Disclosures

Disclosure: Ronald M. Witteles, MD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Alnylam Pharmaceuticals, Inc.; Pfizer Inc.
Received grants for clinical research from: Eidos Therapeutics; Pfizer Inc.

Editors

Joy P. Marko, MS, APN-C, CCMEP

Scientific Director, Medscape, LLC

Disclosures

Disclosure: Joy P. Marko, MS, APN-C, CCMEP, has disclosed no relevant financial relationships.

Kalanethee Paul-Pletzer, PhD

Scientific Director, Medscape, LLC

Disclosures

Disclosure: Kalanethee Paul-Pletzer, PhD, has disclosed no relevant financial relationships.

Nurse Planner

Amy Bernard, MS, BSN, RN-BC, CHCP

Lead Nurse Planner, Medscape, LLC

Disclosures

Disclosure: Amy Bernard, MS, BSN, RN-BC, CHCP, has disclosed no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Abbott Laboratories; Medtronic, Inc.

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Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.50 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

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Clinical Burden of Delayed Diagnosis and Impact on Mortality: What Happens If the Patient Is Misdiagnosed?

« Back

Clinical Burden of Delayed Diagnosis and Impact on Mortality: What Happens If the Patient Is Misdiagnosed?
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Slide 1.

Delayed Diagnosis: Consequences ^[12,13]
- Death is the most devastating effect of a late diagnosis, especially in patients with AL amyloidosis
- Delayed diagnosis increases disease burden as multiple organs are affected
[ CLOSE WINDOW ]

Slide 2.

Staging of AL Amyloidosis and Prognosis ^[14]
- Patients with elevated biomarkers and free light-chain difference have the worst outcomes
[ CLOSE WINDOW ]

Slide 3.

Cardiac AL Amyloidosis: A Race Against Time
- Ruling in/out AL amyloidosis is a priority in suspected CA
[ CLOSE WINDOW ]

Slide 4.

Diagnostic Algorithm ^[15]
- AL amyloidosis can be ruled in/out with free light-chain assay
- The assay is available in all laboratories
[ CLOSE WINDOW ]

Slide 5.

Roadmap for Early Diagnosis
[ CLOSE WINDOW ]

Slide 6.

« Back

Page 3 of 7

Patient Assessment and Diagnosis of Amyloidosis

CME / ABIM MOC / CE Information Download Slides

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References

Faculty and Disclosures

Moderator

Mathew Maurer, MD

Panelists

Jose Nativi-Nicolau, MD

Ronald M. Witteles, MD

Editors

Joy P. Marko, MS, APN-C, CCMEP

Kalanethee Paul-Pletzer, PhD

Nurse Planner

Amy Bernard, MS, BSN, RN-BC, CHCP

Peer Reviewer

CME / ABIM MOC / CE

Amyloidosis in Cardiology Practice: A Race Against Time

Target Audience and Goal Statement

Disclosures

Moderator

Mathew Maurer, MD

Panelists

Jose Nativi-Nicolau, MD

Ronald M. Witteles, MD

Editors

Joy P. Marko, MS, APN-C, CCMEP

Kalanethee Paul-Pletzer, PhD

Nurse Planner

Amy Bernard, MS, BSN, RN-BC, CHCP

Peer Reviewer

Accreditation Statements

For Physicians

For Nurses

Instructions for Participation and Credit

Amyloidosis in Cardiology Practice: A Race Against Time

Clinical Burden of Delayed Diagnosis and Impact on Mortality: What Happens If the Patient Is Misdiagnosed?

Clinical Burden of Delayed Diagnosis and Impact on Mortality: What Happens If the Patient Is Misdiagnosed?

Slide 1.

Delayed Diagnosis: Consequences [12,13]

Slide 2.

Staging of AL Amyloidosis and Prognosis [14]

Slide 3.

Cardiac AL Amyloidosis: A Race Against Time

Slide 4.

Diagnostic Algorithm [15]

Slide 5.

Roadmap for Early Diagnosis

Slide 6.

Delayed Diagnosis: Consequences ^[12,13]

Staging of AL Amyloidosis and Prognosis ^[14]

Diagnostic Algorithm ^[15]