Jacobson TA. NLA Task Force on Statin Safety-2014 update. J Clin Lipidol. 2014;8:S1-S4.
Mach F, Ray KK, Wicklund O, et al. Adverse effects of statin therapy: perception vs. the evidence - focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract; European Heart Journal (2018) 0, 1-18.
Maddox TM, Borden WB, Tang F, et al. Implications of the 2013 ACC/AHA Cholesterol Guidelines for Adults in Contemporary Cardiovascular Practice: Insights From the NCDR PINNACLE Registry. JACC. 2014;64:2183-2192.
Virani SS, Woodard LD, Ramsey DJ, et al. Gender disparities in evidence-based statin therapy in patients with cardiovascular disease. Am J Cardiol. 2015;115:21-26.
Colantonio LD, Huang L, Monda KL, et al. Adherence to High-Intensity Statins Following a Myocardial Infarction Hospitalization Among Medicare Beneficiaries. JAMA Cardiol. 2017;2:890-895.
Serban MC, Colantonio LD, Manthripragada AD, et al. Statin Intolerance and Risk of Coronary Heart Events and All-Cause Mortality Following Myocardial Infarction. J Am Coll Cardiol. 2017;69:1386-1395.
Guyton JR, Bays HE, Grundy SM, et al. An assessment by the Statin Intolerance Panel: 2014 update. J Clin Lipidol. 2014;8:S72-S81.
Rosenson RS, Baker SK, Jacobson TA, et al. An assessment by the Statin Muscle Safety Task Force: 2014 update. J Clin Lipidol. 2014;8:S58-S71.
Brush JE, Jr, Handberg EM, Biga C, et al. 2015 ACC Health Policy Statement on Cardiovascular Team-Based Care and the Role of Advanced Practice Providers. J Am Coll Cardiol. 2015;65:2118-2136.
Ross, J, NLA Lipid University https://www.lipid.org/sites/default/files/4-_lipid_u-pharmacologic_therapies-_brown.pdf. Accessed 10/11/18.
Stone NJ, Robinson JG, Lichtenstein AH, et al. Treatment of blood cholesterol to reduce atherosclerotic cardiovascular disease risk in adults: synopsis of the 2013 American College of Cardiology/American Heart Association cholesterol guideline. Ann Intern Med. 2014;160:339-343.
Toth PP, Journal of Fam Practice medicine June 2012 · Vol. 61, No. 06 Suppl: S34-S39.
Orringer CE, Jacobson TA, Saseen JJ, et al. Update on the use of PCSK9 inhibitors in adults: Recommendations from an Expert Panel of the National Lipid Association. J Clin Lipidol. 2017;11:880-890.
Rosenson RS, Baker SK, Jacobson TA, et al. An assessment by the Statin Muscle Safety Task Force: 2014 update. J Clin Lipidol. 2014;8:S58-S71.

CME / CE

Exploring Statin Intolerance: Real World Data

Authors: James A. Underberg, MD; Joseph J. Saseen, PharmD
CME / CE Released: 11/9/2018
THIS ACTIVITY HAS EXPIRED FOR CREDIT
Valid for credit through: 11/9/2019, 11:59 PM EST

Target Audience and Goal Statement

This activity is intended for cardiologists, diabetologists and endocrinologists, primary care physicians, nurses, nurse practitioners (NPs), pharmacists, and all clinicians interested in management of dyslipidemia.

The goal of this activity is to encourage and improve teamwork when managing patients with statin intolerance.

Upon completion of this activity, participants will:

Have greater competence related to
- effective team-based strategies to address statin intolerance in high-risk patients
- use of HCP-patient communication strategies to improve adherence to statin therapy

Disclosures

As an organization accredited by the ACCME, Medscape, LLC, requires everyone who is in a position to control the content of an education activity to disclose all relevant financial relationships with any commercial interest. The ACCME defines "relevant financial relationships" as financial relationships in any amount, occurring within the past 12 months, including financial relationships of a spouse or life partner, that could create a conflict of interest.

Medscape, LLC, encourages Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration, at first mention and where appropriate in the content.

Faculty

James Underberg, MD

Clinical Assistant Professor of Medicine
NYU School of Medicine
NYU Center for CVD Prevention
Director
Bellevue Hospital Lipid Clinic
New York, New York

Disclosures

Disclosure: James A. Underberg, MD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Amarin Corporation plc; Amgen Inc.
Served as a speaker or a member of a speakers bureau for: Aegerion Pharmaceuticals, Inc.; Akcea Therapeutics; Alexion Pharmaceuticals, Inc.; Amarin Corporation plc; Amgen Inc.; Pfizer Inc.; Regeneron Pharmaceuticals, Inc.; Sanofi
Received grants for clinical research from: Amarin Corporation plc; Amgen Inc.
Other: Advisory Boards: Aegerion Pharmaceuticals, Inc.; Akcea Therapeutics; Alexion Pharmaceuticals, Inc.; Amarin Corporation plc; Ambry Genetics; Amgen Inc.; Regeneron Pharmaceuticals, Inc.; Sanofi

Dr Underberg does not intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

Dr Underberg does not intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

Joseph Saseen, PharmD

Professor
Vice Chair
University of Colorado Skaggs School of Pharmacy
Aurora, Colorado

Disclosures

Disclosure: Joseph J. Saseen, PharmD, has disclosed no relevant financial relationships.

Dr Saseen does not intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by (Select as applicable…).

Dr Saseen does not intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

Steering Committee

Alan S. Brown, MD

Director
Advocate Heart Institute
Advocate Lutheran General Hospital
Park Ridge, Illinois

Disclosures

Disclosure: Alan S. Brown, MD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Akcea Therapeutics; Amgen Inc.; Kastle Therapeutics; Merck & Co., Inc.; Regeneron Pharmaceuticals, Inc.; Sanofi
Served as a speaker or a member of a speakers bureau for: Amgen Inc.; Kowa Company Ltd.; Regeneron Pharmaceuticals, Inc.; Sanofi

Harold Edward Bays, MD

Medical Director
Louisville Metabolic and Atherosclerosis Research Center
Louisville, Kentucky

Disclosures

Disclosure: Harold Edward Bays, MD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Akcea Therapeutics; Alnylam Pharmaceuticals, Inc.; Amgen Inc.; AstraZeneca Pharmaceuticals LP; Eisai Inc.; Esperion Therapeutics, Inc.; Ionis Pharmaceuticals, Inc.; Janssen Pharmaceuticals; Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Kowa Company Ltd.; Lilly; Merck & Co., Inc.; Novartis Pharmaceuticals Corporation; ProSciento; Regeneron Pharmaceuticals, Inc.; Sanofi
Served as a speaker or a member of a speakers bureau for: Amarin Corporation plc; Amgen Inc.; Eisai Inc.; Kowa Company Ltd.; Orexigen Therapeutics, Inc.; Regeneron Pharmaceuticals, Inc.; Sanofi
Received grants for clinical research from: Alere; Allergan, Inc.; Amarin Corporation plc; Amgen Inc.; AstraZeneca Pharmaceuticals LP; Boehringer Ingelheim Pharmaceuticals, Inc.; Bristol-Myers Squibb Company; Catabasis Pharmaceuticals, Inc.; Chiltern; ChromaDex, Inc.; Dr. Reddy's Laboratories Ltd.; Eisai Inc.; Elcelyx Therapeutics, Inc.; Esperion Therapeutics, Inc.; Ferrer; Gemphire Therapeutics Inc.; Gilead Sciences, Inc.; GlaxoSmithKline; Home Access Health; Ionis Pharmaceuticals, Inc.; iSpecimen; Janssen Pharmaceuticals; Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Lilly; Merck & Co., Inc.; Nektar Therapeutics; Nichi-Iko Pharmaceutical Co., Ltd.; Novartis Pharmaceuticals Corporation; Novo Nordisk; Omthera Pharmaceuticals, Inc.; Pfizer Inc; Regeneron Pharmaceuticals, Inc.; Sanofi; Selecta Biosciences, Inc.; Takeda Pharmaceuticals North America, Inc.

Joseph L. Lillo, DO

Assistant Professor
Family Medicine
Midwestern University College of Osteopathic Medicine
Glendale, Arizona, United States

Disclosures

Disclosure: Joseph L. Lillo, DO, has disclosed the following relevant financial relationships:
Served as a speaker or a member of a speakers bureau for: Amarin Corporation plc; Amgen Inc.; Kowa Company Ltd.; Sanofi

Kevin C. Maki, PhD

Chief Scientist
Midwest Biomedical Research
Wheaton, Illinois, United States

Disclosures

Disclosure: Kevin C. Maki, PhD, has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: Akcea Therapeutics; Amgen Inc.; Kowa Company Ltd.; Regeneron Pharmaceuticals, Inc.; Sancilio & Company, Inc.

Kausik Ray, MBChB, MD, MPhil (Cantab), FRCP (Lon), FRCP (Ed)

Professor
Public Health
Imperial College London
London, United Kingdom

Disclosures

Disclosure: Kausik Ray, MBChB, MD, MPhil (Cantab), FRCP (Lon), FRCP (Ed), has disclosed the following relevant financial relationships:
Served as an advisor or consultant for: AbbVie Inc.; Amgen Inc.; Cerenis Therapeutics; Ionis Pharmaceuticals, Inc.; Lilly; Medco Health Solutions, Inc.; Regeneron Pharmaceuticals, Inc.; Sanofi
Served as a speaker or a member of a speakers bureau for: Algorithme Pharma inc.; AstraZeneca Pharmaceuticals LP; Boehringer Ingelheim Pharmaceuticals, Inc.; Cipla Ltd.; Kowa Company Ltd.; Pfizer Inc; Takeda Pharmaceuticals North America, Inc.
Received grants for clinical research from: Amgen Inc.; Pfizer Inc; Regeneron Pharmaceuticals, Inc.; Sanofi

Joyce L. Ross, MSN, CRNP, CS

Diplomat
Accreditation Council for Clinical Lipidology
Immediate Past President
National Lipid Association
Past President
Preventive Cardiovascular Nurses Association
Philadelphia, Pennsylvania

Disclosures

Disclosure: Joyce L. Ross, MSN, CRNP, CS, has disclosed the following relevant financial relationships:
Served as a speaker or a member of a speakers bureau for: Amarin Corporation plc; Amgen Inc.; Kaneka Americas Holding, Inc.; Kowa Company Ltd.; Regeneron Pharmaceuticals, Inc.; Sanofi

Editor

Joy P. Marko, MS, APN-C, CCMEP

Scientific Director, Medscape, LLC

Disclosures

Disclosure: Joy P. Marko, MS, APN-C, CCMEP, has disclosed no relevant financial relationships.

CME / CE Reviewer

Amy Bernard, MS, BSN, RN-BC, CHCP

Lead Nurse Planner, Medscape, LLC

Disclosures

Disclosure: Amy Bernard, MS, BSN, RN-BC, CHCP, has disclosed no relevant financial relationships.

Accreditation Statements

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For Physicians

Medscape, LLC designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

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For Pharmacists

Medscape designates this continuing education activity for 0.25 contact hour(s) (0.025 CEUs) (Universal Activity Number JA0007105-0000-18-249-H01-P).

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For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]

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There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 75% on the post-test.

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You may now view or print the certificate from your CME/CE Tracker. You may print the certificate but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period you can print out the tally as well as the certificates from the CME/CE Tracker.

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From Medscape Education Cardiology

CME / CE

Exploring Statin Intolerance: Real World Data

Authors: James A. Underberg, MD; Joseph J. Saseen, PharmDFaculty and Disclosures

THIS ACTIVITY HAS EXPIRED FOR CREDIT

CME / CE Released: 11/9/2018

Valid for credit through: 11/9/2019, 11:59 PM EST

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Disclaimer

The educational activity presented above may involve simulated case-based scenarios. The patients depicted in these scenarios are fictitious and no association with any actual patient is intended or should be inferred.

The material presented here does not necessarily reflect the views of Medscape, LLC, or companies that support educational programming on medscape.org. These materials may discuss therapeutic products that have not been approved by the US Food and Drug Administration and off-label uses of approved products. A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or employing any therapies described in this educational activity.

References

Faculty and Disclosures

Faculty

James Underberg, MD

Joseph Saseen, PharmD

Steering Committee

Alan S. Brown, MD

Harold Edward Bays, MD

Joseph L. Lillo, DO

Kevin C. Maki, PhD

Kausik Ray, MBChB, MD, MPhil (Cantab), FRCP (Lon), FRCP (Ed)

Joyce L. Ross, MSN, CRNP, CS

Editor

Joy P. Marko, MS, APN-C, CCMEP

CME / CE Reviewer

Amy Bernard, MS, BSN, RN-BC, CHCP

CME / CE

Exploring Statin Intolerance: Real World Data

Target Audience and Goal Statement

Disclosures

Faculty

James Underberg, MD

Joseph Saseen, PharmD

Steering Committee

Alan S. Brown, MD

Harold Edward Bays, MD

Joseph L. Lillo, DO

Kevin C. Maki, PhD

Kausik Ray, MBChB, MD, MPhil (Cantab), FRCP (Lon), FRCP (Ed)

Joyce L. Ross, MSN, CRNP, CS

Editor

Joy P. Marko, MS, APN-C, CCMEP

CME / CE Reviewer

Amy Bernard, MS, BSN, RN-BC, CHCP

Accreditation Statements

For Physicians

For Nurses

For Pharmacists

Instructions for Participation and Credit

Exploring Statin Intolerance: Real World Data