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CME / ABIM MOC

Gene Therapy: Past, Present, and Future

  • Authors: Steven W. Pipe, MD; David Lillicrap, MD; Ulrike M. Reiss, MD
  • CME / ABIM MOC Released: 6/25/2018
  • THIS ACTIVITY HAS EXPIRED FOR CREDIT
  • Valid for credit through: 6/25/2019, 11:59 PM EST
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Target Audience and Goal Statement

This activity is intended for hematologists, pediatricians, and other healthcare professionals who manage patients with hemophilia.

The goal of this activity is to discuss the evolution of gene therapy, including its development, ongoing research, and current and future uses, as well as how it may be used in hemophilia in the future.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • History of gene therapy
    • Different approaches being investigated for gene therapies


Disclosures

As an organization accredited by the ACCME, Medscape, LLC, requires everyone who is in a position to control the content of an education activity to disclose all relevant financial relationships with any commercial interest. The ACCME defines "relevant financial relationships" as financial relationships in any amount, occurring within the past 12 months, including financial relationships of a spouse or life partner, that could create a conflict of interest.

Medscape, LLC, encourages Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration, at first mention and where appropriate in the content.


Moderators

  • Steven W. Pipe, MD

    Professor of Pediatrics and Pathology
    University of Michigan
    Ann Arbor, Michigan, United States

    Disclosures

    Disclosure: Steven W. Pipe, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Bayer HealthCare; BioMarin Pharmaceutical Inc.; Bioverativ; CSL Behring; Novo Nordisk; Pfizer Inc.; Roche; Spark; Shire; UniQure
    Received grants for clinical research from: Shire

    Dr Pipe does intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

    Dr Pipe does intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

Panelists

  • David Lillicrap, MD

    Professor
    Department of Pathology and Molecular Medicine
    Queen's University
    Kingston, Ontario, Canada

    Disclosures

    Disclosure: David Lillicrap, MD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Bayer HealthCare; Bioverativ; CSL Behring; Octapharma; Roche
    Received grants for clinical research from: Bioverativ; CSL Behring; Octapharma

    Dr Lillicrap does not intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

    Dr Lillicrap does intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

  • Ulrike M. Reiss, MD

    Associate Member
    Director of Clinical Hematology
    Director
    Pediatric Hemophilia Treatment Center
    Department of Hematology
    St. Jude Children's Research Hospital
    Memphis, Tennessee, United States

    Disclosures

    Disclosure: Ulrike M. Reiss, MD, has disclosed the following relevant financial relationships:
    Received grants for clinical research from: Alexion Pharmaceuticals, Inc.; Daiichi Sankyo, Inc.

    Dr Reiss does not intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

    Dr Reiss does intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.

Steering Committee

  • John Pasi, MB ChB, PhD, FRCP, FRCPath, FRCPCH

    Professor of Haemostasis and Thrombosis
    Barts and the London School of Medicine and Dentistry
    London, United Kingdom

    Disclosures

    Disclosure: John Pasi, MB ChB, PhD, FRCP, FRCPath, FRCPCH, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Alnylam Pharmaceuticals, Inc; Biogen Idec Inc.; BioMarin Pharmaceutical Inc.; Octapharma; Roche; Shire; Swedish Orphan Biovitrum
    Served as a speaker or a member of a speakers bureau for: Bayer HealthCare Pharmaceuticals; Biotest; Novo Nordisk; Pfizer Inc

  • Johnny Mahlangu, BSc, MBBCh, MMed, FCPath

    Professor of Haematology
    Faculty of Health Sciences
    Department of Molecular Medicine and Haematology
    University of the Witwatersrand
    Head of Clinical Haematology Ward and Service
    Charlotte Maxeke Johannesburg Academic Hospital
    Johannesburg, South Africa

    Disclosures

    Disclosure: Johnny Mahlangu, BSc, MBBCh, MMed, FCPath, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Amgen Inc.; Baxalta; Bayer HealthCare; Biogen; Biotest; CSL Behring; Catalyst Pharmaceutical Partners, Inc.; Novo Nordisk; Roche; Spark
    Served as a speaker or a member of a speakers bureau for: Alnylam Pharmaceuticals, Inc; Bayer HealthCare; Biogen; Biotest; Novo Nordisk; Pfizer Inc.; Swedish Orphan Biovitrum; Roche; Shire
    Received grants for clinical research from: Bayer HealthCare; Biogen; BioMarin Pharmaceutical Inc.; CSL Behring; Novo Nordisk; Swedish Orphan Biovitrum; Roche; Unique Pharmaceuticals

  • Margareth C. Ozelo, MD, PhD

    Assistant Professor
    Director
    IHTC Hemocentro UNICAMP
    University of Campinas
    Director
    WFH International Hemophilia Training Center
    Sao Paulo, Brazil

    Disclosures

    Disclosure: Margareth C. Ozelo, MD, PhD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: BioMarin Pharmaceutical Inc.; CSL Behring; Novo Nordisk; Pfizer Inc.; Roche; Shire
    Served as a speaker or a member of a speakers bureau for: BioMarin Pharmaceutical Inc.; Grifols; Novo Nordisk; Pfizer Inc.; Roche; Shire
    Received grants for clinical research from: Bioverativ; Pfizer Inc.; Shire

  • Flora Peyvandi, MD, PhD

    Professor of Internal Medicine
    University of Milan
    Director
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center
    Milan, Italy

    Disclosures

    Disclosure: Flora Peyvandi, MD, PhD, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: Kedrion Biopharma Inc.; LFB SA
    Served as a speaker or a member of a speakers bureau for: Ablynx; Alnylam Pharmaceuticals, Inc; F. Hoffmann-La Roche; Grifols; Shire; Swedish Orphan Biovitrum
    Other: Advisory board member for Ablynx; F. Hoffmann-La Roche; Shire

Editor

  • Charlotte Warren

    Scientific Director, Medscape, LLC

    Disclosures

    Disclosure: Charlotte Warren has disclosed no relevant financial relationships.

Additional Planners

  • Amanda Bok

    Course Director, Chief Executive Officer, European Haemophilia Consortium (EHC), Brussels, Belgium

    Disclosures

    Disclosure: Amanda Bok has disclosed no relevant financial relationships.

  • Neil Frick, MS

    Course Director, Vice President for Medical Programs and Information, National Hemophilia Foundation, New York, New York.

    Disclosures

    Disclosure: Neil Frick, MS, has disclosed no relevant financial relationships.

  • Fiona Robinson, PhD

    Course Director, Educational Materials Manager, World Federation of Hemophilia (WFH), Montreal, Quebec, Canada

    Disclosures

    Disclosure: Fiona Robinson, PhD, has disclosed no relevant financial relationships.

  • Georghia Michael, PhD

    Medical Writing Consultant, World Federation of Hemophilia (WFH), Montreal, Quebec, Canada

    Disclosures

    Disclosure: Georghia Michael, PhD, has disclosed the following relevant financial relationships: Owns stock, stock options, or bonds from: GlaxoSmithKline

CME Reviewer

  • Amy H. Seung, PharmD, BCOP

    Disclosures

    Amy H. Seung, PharmD, BCOP has disclosed the following relevant financial relationship:Served as an advisor or consultant for Beyondspring Pharmaceuticals

Peer Reviewer

This activity has been peer reviewed and the reviewer has disclosed no relevant financial relationships.


Accreditation Statements

Medscape

Interprofessional Continuing Education

In support of improving patient care, Medscape, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 0.50  AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.50 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

    Medscape, LLC staff have disclosed that they have no relevant financial relationships.

    Contact This Provider

For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]


Instructions for Participation and Credit

There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 70% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read the target audience, learning objectives, and author disclosures.
  2. Study the educational content online or printed out.
  3. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period you can print out the tally as well as the certificates from the CME/CE Tracker.

*The credit that you receive is based on your user profile.

CME / ABIM MOC

Gene Therapy: Past, Present, and Future

Authors: Steven W. Pipe, MD; David Lillicrap, MD; Ulrike M. Reiss, MDFaculty and Disclosures
THIS ACTIVITY HAS EXPIRED FOR CREDIT

CME / ABIM MOC Released: 6/25/2018

Valid for credit through: 6/25/2019, 11:59 PM EST

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Educational Impact Challenge

The goal of this activity is to discuss the evolution of gene therapy, including its development, ongoing research, and current and future uses, as well as how it may be used in hemophilia in the future.

Before you begin this activity, please assess your clinical knowledge by completing this brief survey. Answering these questions again after the activity will allow you to see what you learned and to compare your answers with those of your peers.

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