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One Size Does Not Fit All: Personalizing Care in HCV

  • Authors: Jordan Feld, MD, MPH
  • CME / ABIM MOC / CE Released: 2/24/2017
  • Valid for credit through: 2/24/2018
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Target Audience and Goal Statement

This activity is intended for gastroenterologists, primary care physicians, ID/HIV specialists, and nurses.

The goal of this activity is to improve clinicians ability to treat hepatitis C virus (HCV) infection in patients with stage 4/5 chronic kidney disease and human immunodeficiency virus (HIV) infection, and identify appropriate use of elbasvir/grazoprevir.

Upon completion of this activity, participants will:

  • have increased knowledge regarding the:
    1. Key safety and efficacy data for emerging/newer HCV antivirals
  • have greater competence related to:
    1. Appropriately incorporating newer HCV antiviral agents into clinical practice in the context of severe renal impairment
    2. Appropriately incorporating newer HCV antiviral agents into clinical practice in the context of HIV coinfection


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Medscape, LLC, encourages Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration, at first mention and where appropriate in the content.


  • Jordan Feld, MD, MPH

    Associate Professor of Medicine, University of Toronto, Ontario, Canada


    Disclosure: Jordan Feld, MD, MPH, has disclosed the following relevant financial relationships:
    Served as an advisor or consultant for: AbbVie Inc.; Bristol-Myers Squibb Company; Gilead Sciences, Inc.; Janssen Pharmaceuticals; Merck & Co., Inc.
    Received grants for clinical research from: Abbott Laboratories; AbbVie Inc.; Gilead Sciences, Inc.; Janssen Pharmaceuticals; Merck & Co., Inc.; Regulus Pharmaceutical Consulting, Inc.

    Dr Feld does intend to discuss off-label uses of drugs, mechanical devices, biologics, or diagnostics approved by the FDA for use in the United States.

    Dr Feld does intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by the FDA for use in the United States.


  • Charles Howe, PharmD

    Scientific Director, Medscape, LLC


    Disclosure: Charles Howe, PharmD, has disclosed he
    Owns stock in GlaxoSmithKline

CME Reviewer / Nurse Planner

  • Amy Bernard, MS, BSN, RN-BC

    Lead Nurse Planner, Medscape, LLC


    Disclosure: Amy Bernard, MS, BSN, RN-BC, has disclosed no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has disclosed no relevant financial relationships.

Accreditation Statements

Medscape, LLC is accredited by the American Nurses Credentialing Center (ANCC), the Accreditation Council for Pharmacy Education (ACPE), and the Accreditation Council for Continuing Medical Education (ACCME), to provide continuing education for the healthcare team.

    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 1.00 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Medscape, LLC staff have disclosed that they have no relevant financial relationships.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

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    For Nurses

  • Awarded 1.0 contact hour(s) of continuing nursing education for RNs and APNs; 0.50 contact hours are in the area of pharmacology.

    Contact This Provider

For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]

Instructions for Participation and Credit

There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 70% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read the target audience, learning objectives, and author disclosures.
  2. Study the educational content online or printed out.
  3. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period you can print out the tally as well as the certificates from the CME/CE Tracker.

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One Size Does Not Fit All: Personalizing Care in HCV

Authors: Jordan Feld, MD, MPHFaculty and Disclosures

CME / ABIM MOC / CE Released: 2/24/2017

Valid for credit through: 2/24/2018



AASLD = American Association for the Study of Liver Diseases
AIDS = acquired immune deficiency syndrome
ALT = alanine transaminase
anti-HAV = hepatitis A virus antibody
ART = antiretroviral therapy
AST = aspartate transaminase
BMI = body mass index
BP = blood pressure
bpm = beats per minute
CBC = complete blood count
cGFR = calculated glomerular filtration rate
CrCl = estimated creatinine clearance
CTP = Child-Turcotte-Pugh
DAA = direct-acting antiviral
DCV = daclatasvir
eGRF = estimated glomerular filtration rate
EBR = elbasvir
EGD = esophagogastroduodenoscopy
ELISA = enzyme-linked immunosorbent assay
ESRD = end-stage renal disease
FDA = US Food and Drug Administration
FTC = emtricitabine
GERD = gastroesophageal reflux disease
GT = genotype
GZR = grazoprevir
HAV = hepatitis A virus
HBsAg = hepatitis B surface antigen
HBV = hepatitis B virus
HCC = hepatocellular carcinoma
HCV = hepatitis C virus
HD = hemodialysis
HDLc = high-density lipoprotein cholesterol
Hgb = hemoglobin
HIV = human immunodeficiency virus
GERD = gastroesophageal reflux disease
HR = heart rate
IDSA = Infectious Diseases Society of America
INR = international normalized ratio
kPa = kilopascal
LDLc = low-density lipoprotein cholesterol
LDV = ledipasvir
NS5A = nonstructural protein 5A
PEG-IFN = pegylated interferon
PrOD = paritaprevir/ritonavir/ombitasvir + dasabuvir
RAS = resistance-associated substitution
RAV = resistance-associated variant
RBV = ribavirin
RR = respiratory rate
SMV = simeprevir
SOF = sofosbuvir
TDF = tenofovir disoproxil fumarate
TDF/FTC = tenofovir disoproxil fumarate/emtricitabine
TDF = tenofovir
VEL = velpatasvir
WBC = white blood cell
WNL = within normal limits

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